Protein Alignment mAChR-B and gar-2

DIOPT Version :10

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_001368076.1
• Gene: gar-2 / 175893
• WormBaseID: WBGene00001518
• Length: 664
• Species: Caenorhabditis elegans
• Alignment Length: 905
• Identity: 246/905 - (27%)
• Similarity: 365/905 - (40%)
• Gaps: 271/905 - (29%)

  Fly   133 TILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYT-IYVLK 196
            ::|:|:.:....|:||.||:.|||::.:|:|||||:||||.|||.:|:|||...:|.|| .|:..
 Worm     5 SVLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNN 69

  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
            ..|..|.:|||||||:||.|||.|.||||.||:|||.|||..|.||:|||..||:.::...|::|
 Worm    70 NEWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVP 134

  Fly   262 ALLFFISIFGWEHFTGK-RDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYD 325
            ::||.:||||:..|||. |.|...:|.|||:.:|..|..:.|.||||||.|:..||.|||:.|..
 Worm   135 SILFSVSIFGYGTFTGTGRILKETECYVQFMTNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKK 199

  Fly   326 MQKRSEAKQRKMQSMVAL---SAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSAC---- 383
            :..:|:.|.:::..:..:   .....:..||:::..              :.:.|...|.|
 Worm   200 LALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSD--------------SPNDTSNSSKCFRTA 250

  Fly   384 ---TTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAF 445
               |||....:..|...|:                     .:.........:|..|......|..
 Worm   251 PPTTTVQTTQTNVGTPPPV---------------------FRNHMTLHNNNMDFTKDNEIVRPPT 294

  Fly   446 DSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYH 510
            ..|:.:..|....:|::|..|...::....::               .::||....|.|..|
 Worm   295 PPDDNTYSNPNFSMISEQLTNGFSRQEPSSVI---------------ERESTAPCVSPEPSH--- 341

  Fly   511 HHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDR 575
                                 .||.:..|:.  ||.|.:    |.|..| .....::|.:..||.
 Worm   342 ---------------------ASLENEFNEN--HHAHFK----PELSLP-FIDADSVSSMVGHDD 378

  Fly   576 L-----VDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDR 635
            |     :.:|...::..|: ..:||    ||:         |:.:   .:|.:....|.:
 Worm   379 LRRAMSIRISRSVSMQGTA-RATPV----IEI---------VENL---EEALKICENLEE----- 421

  Fly   636 PFGNSSGNSELALTYDLMTNSELRYMD--ESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARR 698
                        |..|...|.|.:..:  |:..|...:.||....|:.|.:.:
 Worm   422 ------------LREDENKNEEEKQKNGLENGGMNHVIIANDEQQPSTSKESE------------ 462

  Fly   699 NPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVR 763
                    |....|| :|..|::                        .|..|::.:.:|.....
 Worm   463 --------QKEEMTP-ENHDPNE------------------------VKVPLIAVSRVESVKST- 493

  Fly   764 RESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSA 828
                        ..||:      ||..:.|.:.|           :....|...:...|.:|:|.
 Worm   494 ------------AGGKV------RRLITQMRSHS-----------IRSKRKANKNKVSTCSPKST 529

  Fly   829 AGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKS 893
            ..:..|                   ||||.||.                        :..|...:
 Worm   530 TSLLLP-------------------PSTSSTTR------------------------ERTRHPVT 551

  Fly   894 LAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPY 958
            :.....|     :.|....|:.||          ..||:||||||||.|||:||||.|:..|||:
 Worm   552 ITLQFQS-----VLSALNFFQRKK----------EYKSRSENRARKALRTITFILGSFIILWTPF 601

  Fly   959 HVLALVEGF---CRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRILKGD 1015
            :|||.:.||   |:..|..|. ||..||:|||.|||:||||||:||||||||.|||.|||
 Worm   602 YVLATIYGFCETCKASPSFNT-LYTISYYLCYMNSPLNPFCYAMANQQFKKTLTRIFKGD 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tmA_mAChR_GAR-2-like	147..>323	CDD:320429	95/177 (54%)
		TM helix 2	168..194	CDD:320429	14/26 (54%)
		TM helix 3	206..236	CDD:320429	22/29 (76%)
		TM helix 4	248..271	CDD:320429	8/22 (36%)
		TM helix 5	293..322	CDD:320429	15/28 (54%)
		7tm_GPCRs	<932..1008	CDD:475119	50/78 (64%)
		TM helix 6	941..963	CDD:410628	13/21 (62%)
		TM helix 7	976..1001	CDD:410628	16/24 (67%)
gar-2	NP_001368076.1	7tmA_mAChR_GAR-2-like	6..>199	CDD:320429	99/192 (52%)
		TM helix 1	7..33	CDD:320429	10/25 (40%)
		TM helix 2	40..66	CDD:320429	14/25 (56%)
		TM helix 3	79..109	CDD:320429	22/29 (76%)
		TM helix 4	121..144	CDD:320429	8/22 (36%)
		TM helix 5	167..196	CDD:320429	15/28 (54%)
		7tm_GPCRs	<575..653	CDD:475119	50/78 (64%)
		TM helix 6	584..606	CDD:410628	13/21 (62%)
		TM helix 7	621..646	CDD:410628	17/25 (68%)