DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and Hrh1

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001239571.1	Gene:	Hrh1 / 15465	MGIID:	107619	Length:	488	Species:	Mus musculus

Alignment Length:	886	Identity:	174/886 - (19%)
Similarity:	258/886 - (29%)	Gaps:	432/886 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 QTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK 196
            |.:.:.:.|:...::|||.|:|||.|...:|.:....|.:|.||:..|:::|.|.||...:|::.
Mouse    26 QLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIM 90

  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
            ..|.||..||..|||:||.....|.::|.::.||||.||:...:|..:||:||....:...|.:
Mouse    91 TKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFL- 154

  Fly   262 ALLFFISIFGWEHFTG-KRDLLPGQCAVQFLKDPIFN--TALIIGYYWTTLIVLFVLYAGIYKTA 323
            :.|:.|.|.||.|||. ..:|...:|...|.....|.  || ||.:|..||::|: .|..|||..
Mouse   155 SFLWVIPILGWHHFTPLAPELREDKCETDFYNVTWFKIMTA-IINFYLPTLLMLW-FYVKIYKAV 217

  Fly   324 YDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIK 388
                 |...:.|:      |:.|:                  |.|.:|:
Mouse   218 -----RRHCQHRQ------LTNGS------------------LPTFLEI---------------- 237

  Fly   389 RLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSV 453
                                           |::.|..|..|     |.....||.
Mouse   238 -------------------------------KLRSEDAKEGA-----KKPGKESPW--------- 257

  Fly   454 NQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHN 518
                         .::||.|.....|..            ||||:
Mouse   258 -------------GVQKRPSRDPTGGLD------------QKSTS-------------------- 277

  Fly   519 QSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPP 583
                                                  :.||.||.:..||..|.:
Mouse   278 --------------------------------------EDPKVTSPTVFSQEGERE--------- 295

  Fly   584 TLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELAL 648
            |:......|..:...|:                                   |.|::.|:
Mouse   296 TVTRPCFRLDVMQTQPV-----------------------------------PEGDARGS----- 320

  Fly   649 TYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTP 713
                                                                 |:|     .||.
Mouse   321 -----------------------------------------------------KAN-----DQTL 327

  Fly   714 SQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPG 778
            ||.:...||||                                         :|
Mouse   328 SQPKMDEQSLS-----------------------------------------TC----------- 340

  Fly   779 KLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEER 843
                    ||.|                         :||..||             .::|....
Mouse   341 --------RRIS-------------------------ETSEDQT-------------LVDRQSFS 359

  Fly   844 ETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHS 908
            .|:||:|:..|                   |:|..|               |.||::|...:|..
Mouse   360 RTTDSDTSIEP-------------------GLGKVK---------------ARSRSNSGLDYIKV 390

  Fly   909 IGKHFKSKKALPLILGVGGRQ--KSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHP 971
            ..|..:|.          .||  .....||.|||.:.:..|:..|:.||.||.:..:|..||.
Mouse   391 TWKRLRSH----------SRQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCN-- 443

  Fly   972 PCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .|.:|.::||:.:|.|.||.:||..|.|.|:.|||||.:||
Mouse   444 SCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKIL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	66/193 (34%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	65/188 (35%)
Hrh1	NP_001239571.1	7tmA_Histamine_H1R	29..480	CDD:320178	169/877 (19%)
		TM helix 1	29..55	CDD:320178	9/25 (36%)
		TM helix 2	62..88	CDD:320178	9/25 (36%)
		TM helix 3	100..130	CDD:320178	13/29 (45%)
		Important for agonist binding. /evidence=ECO:0000250	107..112		2/4 (50%)
		TM helix 4	142..163	CDD:320178	5/21 (24%)
		TM helix 5	187..216	CDD:320178	12/30 (40%)
		TM helix 6	218..439	CDD:320178	82/637 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..337		33/295 (11%)
		Important for agonist binding. /evidence=ECO:0000250	425..429		1/3 (33%)
		TM helix 7	448..473	CDD:320178	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920