DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-B and Gpr162

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001342186.1	Gene:	Gpr162 / 14788	MGIID:	1315214	Length:	588	Species:	Mus musculus

Alignment Length:	588	Identity:	118/588 - (20%)
Similarity:	212/588 - (36%)	Gaps:	154/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK----G 197
            |:....|.:|.:..|..::|:....:...:|....:..||.|.:|:..|.:..:.:..|:    .
Mouse    17 ALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASS 81

  Fly   198 YWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPA 262
            .:|....:|.:::|..||:.|.:.:||..::..|...|:....||....:.:.::.|...|::..
Mouse    82 DYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSF 146

  Fly   263 LLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPI-------FNTALIIGYYWTTLIVLFVLYAGI- 319
            :|..:...|| |..|:|....| |  ||:...|       |:..|:.|      ||:.::...|
Mouse   147 ILSTLPSIGW-HNNGERYYARG-C--QFIVSKIGLGFGVCFSLLLLGG------IVMGLVCVAIT 201

  Fly   320 -YKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIG----------VIEEKILKTKVELA 373
             |:|.:...:|:...:|        :.|::...||...|:|          |:|:...|.:..|.
Mouse   202 FYQTLWARPRRARQARR--------AGGSVGTKAGGLGGLGTRPAFEVPAIVVEDTRGKRRSSLD 258

  Fly   374 GDQ--------TDLDSACTTVIKRLSG------------SGQANP---LAVATEEVEK--MTP-- 411
            |.:        |:|.||...:...|:|            |..|.|   |||....:.:  :.|
Mouse   259 GSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSF 323

  Fly   412 ----EQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRS 472
                |:.||....:.|:.    .|:.:|.         |.|::.:.:.    .|..::..:|
Mouse   324 IWSCERYRADVRTVWEQC----VAIMSED---------DGDDDGTCDD----YTDGRVCKIR--- 368

  Fly   473 SIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQ-YHHHQQHHHNQSPLQRAQSKEEMR---- 532
                 |.|..|    .|.|:  :..|..|.:...|. :...::.|:.|.||.|..|.:|..
Mouse   369 -----FDANGA----TGSGS--RDPTQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIFST 422

  Fly   533 ------SLHHHQNQQQ--------------PHH--QHHQNQPNPPLDRPKRTSCSTLSQIAEHDR 575
                  .||...:...              |.:  |.|:.:.....:..:....::|.|..|...
Mouse   423 PRAPGSFLHKWSSSDDIRILPAQSRALGGPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGV 487

  Fly   576 LVDLSAPPTLLNTSDPLSPVDLAPIEVPS---DQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPF 637
            |.....||                 ..|.   :::...:.:|.||.|.|...|:|    ...||.
Mouse   488 LGSGGGPP-----------------RGPGFFREEITTFIDETPLPSPTASPGPSP----RRPRPL 531

  Fly   638 GNS 640
            |.|
Mouse   532 GFS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	44/203 (22%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	43/198 (22%)
Gpr162	NP_001342186.1	7tmA_GPR162	14..335	CDD:320572	73/335 (22%)
		TM helix 1	15..41	CDD:320572	5/23 (22%)
		TM helix 2	48..72	CDD:320572	5/23 (22%)
		TM helix 3	90..120	CDD:320572	8/29 (28%)
		TM helix 4	132..154	CDD:320572	3/21 (14%)
		TM helix 5	179..207	CDD:320572	8/33 (24%)
		TM helix 6	263..293	CDD:320572	6/29 (21%)
		TM helix 7	303..328	CDD:320572	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..545		11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8273
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860