Protein Alignment mAChR-B and mAChR-A

DIOPT Version :10

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: XP_061517078.1
• Gene: mAChR-A / 1275250
• VectorBaseID: AGAMI1_011485
• Length: 679
• Species: Anopheles gambiae
• Alignment Length: 930
• Identity: 210/930 - (22%)
• Similarity: 331/930 - (35%)
• Gaps: 332/930 - (35%)

  Fly   114 SSSDS--------EILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNY 170
            |||||        |:|....|.::|.|.|::.|...:..||||.||::|:::|.:|:.::..|||
Mosquito    43 SSSDSLPTANGTLEVLVEDPPTYSLAQIIILGIIATVLSILTVAGNVMVMISFKIDKQLQTISNY 107

  Fly   171 FIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSV 235
            |:.|||..|..||.:|||.:::..|.|||.|||.:||.||::||.....|...:|:|:.|||.||
Mosquito   108 FLFSLAIADFAIGLISMPLFSVTTLLGYWPLGPHICDTWLALDYLASNASVLNLLIISFDRYFSV 172

  Fly   236 KIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDP---IFN 297
            .....||:.||.||...|:...|.|..||:...|:.|.:..|||.:...:|.:||::..   .|.
Mosquito   173 TRPLTYRAKRTTTRAAIMIGAAWGISLLLWPPWIYSWPYIEGKRTVPEKECYIQFIETNHYITFG 237

  Fly   298 TALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIE 362
            ||  |..::..:.|:..||..|::         |.|:|
Mosquito   238 TA--IAAFYVPVTVMCFLYYRIWR---------ETKKR--------------------------- 264

  Fly   363 EKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKK 427
            :|.||   .|.||            ::...|.::|    :::|...:.........|.:.|:..:
Mosquito   265 QKELK---NLTGD------------RKKDSSKRSN----SSDENTAVNHSGGHVLPASVAEDGWR 310

  Fly   428 R---EAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNN--MRKRSSIGLVFGAQAALLAT 487
            |   |::.|||                ||.....::......:  :.:||||.:
Mosquito   311 RPRSESSADAE----------------SVYMTNAVLPDGAYGHGMLSRRSSITM----------- 348

  Fly   488 RGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQP 552
              .|..:|.||....|                        ||...:..|...:....:.:...:|
Mosquito   349 --NGVPKKPTTFFGGI------------------------KEWCIAWWHSGREDSDDYGYDVEEP 387

  Fly   553 NPPLDRPKRTSCSTLSQIAEHDRLVDLS-APPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTIL 616
            :                        ||. |.|..:.|..|.|......:.|
Mosquito   388 S------------------------DLGYATPVSIETPLPSSVTRCTSLNV-------------- 414

  Fly   617 PPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPND 681
                       :.|.|    ...|.|.|.:.                  :|:..:      ||.
Mosquito   415 -----------IRDPY----VAGSGGRSNVV------------------SMIPDI------SPT- 439

  Fly   682 SVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLS--------LNLNPNHNQSQSQS 738
                  |:.|..||............|.| .|:.|:..|:|:|        :.|.|......
Mosquito   440 ------PIRPALPPLAHLQDMHGARDSRS-LPNSNRLGSRSVSQDSVYTILIRLPPEGGSGD--- 494

  Fly   739 IEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILY 803
             |.|.:|:.        |:|                |||  ::...|.||   |:.:...|.||
Mosquito   495 -ERAPSIKM--------IQD----------------DVP--MSMTVPPRR---PLPSRDSDYIL- 528

  Fly   804 SPMPPMPLSP-KVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVG 867
                  |::. :..|:|.....|.||..::.|:
Mosquito   529 ------PVATRRQSTATTDFRLPLSAKIISKPL-------------------------------- 555

  Fly   868 GGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSK 932
                                :::::.|       .:|.:....:..|.||            ||:
Mosquito   556 --------------------SKQQQQL-------HQANLAQTARQVKKKK------------KSQ 581

  Fly   933 SENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCY 997
            .:.:..||.:|:|.||..|:..||||::|.|::.......||.:.|:.|.|.|||.||.:||.||
Mosquito   582 EKRQETKAAKTLSAILLSFIITWTPYNILVLLKPLTACTKCIPQELWDFFYALCYINSTINPVCY 646

  Fly   998 ALANQQFKKTFTRILKGDLH 1017
            ||.|..|::|:.|||....|
Mosquito   647 ALCNASFRRTYVRILTCKWH 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tmA_mAChR_GAR-2-like	147..>323	CDD:320429	68/178 (38%)
		TM helix 2	168..194	CDD:320429	13/25 (52%)
		TM helix 3	206..236	CDD:320429	13/29 (45%)
		TM helix 4	248..271	CDD:320429	8/22 (36%)
		TM helix 5	293..322	CDD:320429	8/31 (26%)
		7tm_GPCRs	<932..1008	CDD:475119	31/75 (41%)
		TM helix 6	941..963	CDD:410628	10/21 (48%)
		TM helix 7	976..1001	CDD:410628	14/24 (58%)
mAChR-A	XP_061517078.1	None