Protein Alignment mAChR-B and mAChR-B

DIOPT Version :10

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: XP_061497816.1
• Gene: mAChR-B / 1274421
• VectorBaseID: AGAMI1_011829
• Length: 1036
• Species: Anopheles gambiae
• Alignment Length: 1187
• Identity: 465/1187 - (39%)
• Similarity: 577/1187 - (48%)
• Gaps: 344/1187 - (28%)

  Fly     9 GEEELTGLNGNSSDSIYTIKNKWITDWSLRRERDKLCSFIFKR--VLTHTECKRLL--------- 62
            |:..::.:| |.|.:|:.|...:|..|.|:|:::|:|.....:  :|.:.||..:|
Mosquito    18 GDYNVSDVN-NRSATIFAINPDFIAQWKLKRKQEKICGEFDSQLDMLNYPECLNILANFLDLKQK 81

  Fly    63 -------EAAKIYGESSDFN----SWPVN--------------EQLQWYRNFDV-----NNTNLL 97
                   |..|..|.:|..|    |:.::              |.|..|.||.:     .:|:
Mosquito    82 SISIVSSEFLKPIGSNSRLNGSDFSFSLDTTLIATGVSSIKEFEHLNSYSNFTLFSWSNESTH-- 144

  Fly    98 LAVRNQSSD--GGSTMSGSSSDSEILG----PVLPPFALWQTILIAICLAICIILTVGGNILVLL 156
             :..|:||:  .|...|......:|:.    .|||||.|||||.||||||||||||:||||||||
Mosquito   145 -SYGNESSNYFPGENFSKVPYHFDIIDESIMQVLPPFDLWQTIFIAICLAICIILTIGGNILVLL 208

  Fly   157 AFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQ 221
            |||||||||||||||||||||||||||||||||||:|||.|||:|||:|||||||||||||||||
Mosquito   209 AFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTVYVLMGYWNLGPLLCDLWLSVDYTVCLVSQ 273

  Fly   222 YTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQC 286
            ||||||||||:||||||||||||||:.:|::|||||||||||||||||||||||.|.||||||||
Mosquito   274 YTVLLITIDRFCSVKIAAKYRSWRTKNKVLWMVTITWIIPALLFFISIFGWEHFVGYRDLLPGQC 338

  Fly   287 AVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGM 351
            |||||||||||||||||||||||:||||||.|||||||||||:|||||||||||||||: ||:||
Mosquito   339 AVQFLKDPIFNTALIIGYYWTTLVVLFVLYGGIYKTAYDMQKKSEAKQRKMQSMVALSS-AMTGM 402

  Fly   352 AGHAAGIGV-------------------IEEKILKTKVELAGDQT----DLDSACTTVIKRLS-- 391
            |...||||:                   :.:|:....|..|||:.    ||....||.::..|
Mosquito   403 ASRTAGIGISKTQSTLLCTDKPMTSSSPLVQKLEAATVLCAGDEAFRKFDLQIQSTTSLQSTSIN 467

  Fly   392 -----------GSGQANPLAVATEEVEK--MTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSP 443
                       .|...:|..:.:|:..:  :......|......|:|...|..::.|||||||||
Mosquito   468 IHVSPSNNDKNFSKSLDPPVLTSEKTNEGIIISNVSHALGDYRVEKATDYEERIEGEKSERSSSP 532

  Fly   444 AFDSDEESSVNQAQQLITQQKLNNMRKRSSIG--LVFGAQAAL---------------------- 484
            |||||||.|.|..|    .|.:....||||:.  ||..|.|::
Mosquito   533 AFDSDEEHSTNVKQ----VQYVKPSHKRSSVAGMLVEAASASVLTSNNATSSISSGNNLSTLPIK 593

  Fly   485 -----------LATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKE-------EM 531
                       |::..:.|:....|||::|:....:..|......|| |.:...|.       |.
Mosquito   594 CLSTSIFEQKALSSTNENNILNCITNSQAIDQELSFAPHSVISQTQS-LAKVSCKTTCLQQILED 657

  Fly   532 RSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCS-TLSQIAEHD-RLVD-----LSAPPTLLNTS 589
            .|.:..|.....|.:..:.:|..|:.....|..| .|..:...| |.:|     |..|...:|.|
Mosquito   658 SSSNGFQIAHVSHLKLREERPQSPISIEDTTGTSDPLKSLDSADLRFMDESSIMLPTPENEINHS 722

  Fly   590 D-------------PLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTP-----LSDDYSDRP 636
            |             ..|......|..|: .:|:.|:|.      ..|||||     :...|
Mosquito   723 DNSFTFLDDVAHLSKYSRCSAQNIANPT-LLHKALIQA------TAQCPTPSPTVLIRSSY---- 776

  Fly   637 FGNSSGNSELALTYDLM-----TNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPA 696
                       |..||:     ||..:.|....::|...:...:.|...:||:
Mosquito   777 -----------LNMDLVSPETATNKNITYHHAQTSMEDKMNNTAVTVGTESVE------------ 818

  Fly   697 RRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHN--------QSQSQSIEEAVAIEKRLLVSY 753
                 ||..|.|           |....|| |.|.|        |:|.|..::...:..|    |
Mosquito   819 -----KSKTNLS-----------SACFKLN-NTNTNYFEEHQNLQTQKQDNDDTFKLSSR----Y 862

  Fly   754 TGI--------EDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMP 810
            .||        ||...|..::|
Mosquito   863 YGISNILNAAEEDSQNVSTQAC------------------------------------------- 884

  Fly   811 LSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGV 875
                                        |:....|:.:.||     .|.||::
Mosquito   885 ----------------------------RVLSNITTSTATN-----FGNTSNS------------ 904

  Fly   876 GATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLI-LGVGG--RQKSKSENRA 937
                           :|.|....:..|..||.||||........|:: :.:||  ||||||||||
Mosquito   905 ---------------KKCLERESSRKKTWFIQSIGKRLNQGMKTPIVDVPIGGISRQKSKSENRA 954

  Fly   938 RKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQ 1002
            ||||||||||||.||||||||||||||.|||..|||:||||:||||||||||||||||||||||:
Mosquito   955 RKAFRTISFILGAFVACWTPYHVLALVVGFCSKPPCVNEHLFMFSYFLCYANSPMNPFCYALANK 1019

  Fly  1003 QFKKTFTRILKGDLHMT 1019
            ||||||||||:||||||
Mosquito  1020 QFKKTFTRILRGDLHMT 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tmA_mAChR_GAR-2-like	147..>323	CDD:320429	160/175 (91%)
		TM helix 2	168..194	CDD:320429	24/25 (96%)
		TM helix 3	206..236	CDD:320429	28/29 (97%)
		TM helix 4	248..271	CDD:320429	18/22 (82%)
		TM helix 5	293..322	CDD:320429	26/28 (93%)
		7tm_GPCRs	<932..1008	CDD:475119	68/75 (91%)
		TM helix 6	941..963	CDD:410628	20/21 (95%)
		TM helix 7	976..1001	CDD:410628	23/24 (96%)
mAChR-B	XP_061497816.1	None