DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and Chrm4

DIOPT Version :9

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:XP_006498717.1 Gene:Chrm4 / 12672 MGIID:88399 Length:498 Species:Mus musculus


Alignment Length:881 Identity:177/881 - (20%)
Similarity:256/881 - (29%) Gaps:442/881 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 QTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK 196
            :.:.||.......::||.|||||:|:..|:|.::..:|||:.|||..|::||..||..||:|::|
Mouse    49 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIK 113

  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
            |||.||.::|||||::||.|...|...:|:|:.|||..|.....|.:.||......|:...|::.
Mouse   114 GYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLS 178

  Fly   262 ALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDM 326
            .:|:..:|..|:...|||.:...||.:|||.:|.......|..::..::::.|||..|     .:
Mouse   179 FVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHI-----SL 238

  Fly   327 QKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLS 391
            ..||                                                             
Mouse   239 ASRS------------------------------------------------------------- 242

  Fly   392 GSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQA 456
                         .|.|..||                     ..|.:::.:.||           
Mouse   243 -------------RVHKHRPE---------------------GPKEKKAKTLAF----------- 262

  Fly   457 QQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSP 521
                                                 .||.....||               :.|
Mouse   263 -------------------------------------LKSPLMKPSI---------------KKP 275

  Fly   522 LQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLL 586
            .....|:||:|                    |..|:                      .|||   
Mouse   276 PPGGASREELR--------------------NGKLE----------------------EAPP--- 295

  Fly   587 NTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYD 651
                            |:           ||||     |.|::|  .|....:|||::       
Mouse   296 ----------------PA-----------LPPP-----PRPVAD--KDTSNESSSGSA------- 319

  Fly   652 LMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQN 716
             ..|::.|...|.|...|:.|               |.||.|....|                  
Mouse   320 -TQNTKERPPTELSTTEAATT---------------PALPAPTLQPR------------------ 350

  Fly   717 QSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLA 781
                     .|||....|:.|           ::...||.|         |:.||.::       
Mouse   351 ---------TLNPASKWSKIQ-----------IVTKQTGSE---------CVTAIEIV------- 379

  Fly   782 ADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETS 846
                                                       |.:.||:.|.            
Mouse   380 -------------------------------------------PATPAGMRPA------------ 389

  Fly   847 DSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGK 911
                                                    ||...|..:.:||..          
Mouse   390 ----------------------------------------ANVARKFASIARNQV---------- 404

  Fly   912 HFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINE 976
                            |:|.:...|.||..|||..||..|:..||||:|:.||..||:  .||.|
Mouse   405 ----------------RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ--SCIPE 451

  Fly   977 HLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .::...|:|||.||.:||.||||.|..|||||..:|
Mouse   452 RVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tm_1 150..>341 CDD:278431 67/190 (35%)
7tm_4 150..>336 CDD:304433 67/185 (36%)
Chrm4XP_006498717.1 7tmA_mAChR_M4 51..483 CDD:341344 174/873 (20%)
TM helix 1 53..77 CDD:341344 10/23 (43%)
TM helix 2 86..108 CDD:341344 11/21 (52%)
TM helix 3 124..146 CDD:341344 10/21 (48%)
TM helix 4 169..185 CDD:341344 3/15 (20%)
TM helix 5 211..234 CDD:341344 4/22 (18%)
TM helix 6 415..440 CDD:341344 13/24 (54%)
TM helix 7 451..476 CDD:341344 13/24 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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