DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and Chrm3

DIOPT Version :9

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_150372.1 Gene:Chrm3 / 12671 MGIID:88398 Length:589 Species:Mus musculus


Alignment Length:962 Identity:197/962 - (20%)
Similarity:306/962 - (31%) Gaps:441/962 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 EAAKIYGESSDFNSWPVNEQLQWYRNFDVNNTNLLLAVRNQSSD--GGSTMSGSSSDSEILGPVL 125
            ||....|..|..:|:.::   |...||..|:|         |||  ||.|               
Mouse    26 EAGLPLGTVSQLDSYNIS---QTSGNFSSNDT---------SSDPLGGHT--------------- 63

  Fly   126 PPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFY 190
                :||.:.||.......::|:.|||||::||.|::.::..:|||:.|||..|::||.:||..:
Mouse    64 ----IWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLF 124

  Fly   191 TIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVT 255
            |.|::...|.||.:.||||||:||.....|...:|:|:.|||.|:.....||:.||..|...|:.
Mouse   125 TTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIG 189

  Fly   256 ITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIY 320
            :.|:|..:|:..:|..|::|.|||.:.||:|.:|||.:|.......|..::..:.::.:||..||
Mouse   190 LAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIY 254

  Fly   321 KTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTT 385
            |   :.:||::                                       ||||           
Mouse   255 K---ETEKRTK---------------------------------------ELAG----------- 266

  Fly   386 VIKRLSGSGQANPLAVATE-EVEKM---TPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFD 446
                |..||        || |.|..   |...|..|:.::|::..||                  
Mouse   267 ----LQASG--------TEAEAENFVHPTGSSRSCSSYELQQQGTKR------------------ 301

  Fly   447 SDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNS--KSIEAMHQY 509
                               ::.||.......|                  ||.|  .|.|.|.|.
Mouse   302 -------------------SSRRKYGGCHFWF------------------TTKSWKPSAEQMDQD 329

  Fly   510 HHHQQHHHNQ---SPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIA 571
            |......:|.   :.|:.:.|.:|                       ..:....|...|.:.::.
Mouse   330 HSSSDSWNNNDAAASLENSASSDE-----------------------EDIGSETRAIYSIVLKLP 371

  Fly   572 EHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRP 636
            .|.         |:||:                         |.||..|..|.|        |:.
Mouse   372 GHS---------TILNS-------------------------TKLPSSDNLQVP--------DKD 394

  Fly   637 FGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPP 701
            .|          |.|:..|:.            .:.|..:....|:.|                 
Mouse   395 LG----------TMDVERNAH------------KLQAQKSMDDRDNCQ----------------- 420

  Fly   702 KSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRES 766
                                                                   :||:|:    
Mouse   421 -------------------------------------------------------KDFSKL---- 426

  Fly   767 CIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGV 831
                                                                             
Mouse   427 ----------------------------------------------------------------- 426

  Fly   832 TPPVPLE-RIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLA 895
              |:.|| .::..:|||:|::                                      .:|:.|
Mouse   427 --PIQLESAVDTAKTSDTNSS--------------------------------------VDKTTA 451

  Fly   896 ASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHV 960
            |...|.|.|   ::.|.|..|....:.     ::|..|..:.:||.:|:|.||..|:..||||::
Mouse   452 ALPLSFKEA---TLAKRFALKTRSQIT-----KRKRMSLIKEKKAAQTLSAILLAFIITWTPYNI 508

  Fly   961 LALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            :.||..||  ..||.:..:...|:|||.||.:||.||||.|:.|:.||..:|
Mouse   509 MVLVNTFC--DSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLL 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tm_1 150..>341 CDD:278431 69/190 (36%)
7tm_4 150..>336 CDD:304433 69/185 (37%)
Chrm3NP_150372.1 7tmA_mAChR_M3 65..>269 CDD:320426 79/260 (30%)
TM helix 1 69..95 CDD:320426 10/25 (40%)
TM helix 2 102..129 CDD:320426 13/26 (50%)
TM helix 3 140..170 CDD:320426 15/29 (52%)
Agonist binding. /evidence=ECO:0000250 147..151 2/3 (67%)
TM helix 4 182..205 CDD:320426 6/22 (27%)
TM helix 5 227..256 CDD:320426 7/31 (23%)
Basolateral sorting signal. /evidence=ECO:0000250 274..280 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..295 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..356 8/55 (15%)
7tm_GPCRs <483..563 CDD:391938 34/78 (44%)
TM helix 6 486..511 CDD:341315 11/24 (46%)
Agonist binding. /evidence=ECO:0000250 506..529 7/24 (29%)
TM helix 7 522..547 CDD:341315 12/24 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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