DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and Chrm1

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001106167.1	Gene:	Chrm1 / 12669	MGIID:	88396	Length:	460	Species:	Mus musculus

Alignment Length:	925	Identity:	172/925 - (18%)
Similarity:	257/925 - (27%)	Gaps:	499/925 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 SSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATD 179
            |.:..:|.|...|   ||...|.|...:..:.||.||:|||::|.|:..::..:|||:.|||..|
Mouse    10 SPNITVLAPGKGP---WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACAD 71

  Fly   180 MLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSW 244
            ::|||.||..||.|:|.|:|.||.:.|||||::||.....|...:|||:.|||.||.....||:.
Mouse    72 LIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAK 136

  Fly   245 RTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTL 309
            ||..|...|:.:.|::..:|:..:|..|::..|:|.:|.|||.:|||..||......:..::..:
Mouse   137 RTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPV 201

  Fly   310 IVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAG 374
            .|:..||..||:
Mouse   202 TVMCTLYWRIYR----------------------------------------------------- 213

  Fly   375 DQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSER 439
                                          |.|
Mouse   214 ------------------------------ETE-------------------------------- 216

  Fly   440 SSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIE 504
                          |:|::|...|               |::     |.|||
Mouse   217 --------------NRARELAALQ---------------GSE-----TPGKG------------- 234

  Fly   505 AMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQ 569

Mouse   235 ----------------------------------------------------------------- 234

  Fly   570 IAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSD 634

Mouse   235 ----------------------------------------------------------------- 234

  Fly   635 RPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPAR-- 697
               |.||.:||.:                                ....:|.    |..||.|
Mouse   235 ---GGSSSSSERS--------------------------------QPGAEGS----PESPPGRCC 260

  Fly   698 ---RNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDF 759
               |.|                                               |||.:|:..|:
Mouse   261 RCCRAP-----------------------------------------------RLLQAYSWKEE- 277

  Fly   760 AKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGT 824
             :...|..:|::                 .||..|....:.::..||    :.|:.:..|.|
Mouse   278 -EEEDEGSMESL-----------------TSSEGEEPGSEVVIKMPM----VDPEAQAPTKQ--- 317

  Fly   825 PQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANR 889
                    ||          .|..||.|.|:..|...     ||.|::.               |
Mouse   318 --------PP----------KSSPNTVKRPTKKGRDR-----GGKGQKP---------------R 344

  Fly   890 EEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVAC 954
            .::.||                                ::|:.|..:.:||.||:|.||..|:..
Mouse   345 GKEQLA--------------------------------KRKTFSLVKEKKAARTLSAILLAFILT 377

  Fly   955 WTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL------- 1012
            ||||:::.||..||:  .|:.|.|:...|:|||.||.:||.||||.|:.|:.||..:|
Mouse   378 WTPYNIMVLVSTFCK--DCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKR 440

  Fly  1013 --------KGDLHMT 1019
                    .|.:|.|
Mouse   441 RWRKIPKRPGSVHRT 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	69/190 (36%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	69/185 (37%)
Chrm1	NP_001106167.1	7tmA_mAChR_M1	26..429	CDD:341356	160/878 (18%)
		TM helix 1	27..53	CDD:341356	10/25 (40%)
		TM helix 2	60..86	CDD:341356	14/25 (56%)
		TM helix 3	98..128	CDD:341356	15/29 (52%)
		TM helix 4	140..163	CDD:341356	5/22 (23%)
		TM helix 5	185..214	CDD:341356	7/111 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..257		14/233 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..297		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..351		16/113 (14%)
		TM helix 6	358..388	CDD:341356	13/29 (45%)
		TM helix 7	397..422	CDD:341356	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920