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Protein Alignment mAChR-B and CHRM2

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_000730.1	Gene:	CHRM2 / 1129	HGNCID:	1951	Length:	466	Species:	Homo sapiens

Alignment Length:	902	Identity:	161/902 - (17%)
Similarity:	259/902 - (28%)	Gaps:	447/902 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 MSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASL 175
            |:.|::.|.....:..|:..::.:.|.:......::|:.|||||:::..|:|:::..:|||:.||
Human     1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSL 65

  Fly   176 AATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAK 240
            |..|::||..||..||:|.:.|||.|||::|||||::||.|...|...:|:|:.|||..|.....
Human    66 ACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLT 130

  Fly   241 YRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYY 305
            |...||......|:...|::..:|:..:|..|:...|.|.:..|:|.:||..:........|..:
Human   131 YPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAF 195

  Fly   306 WTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKV 370
            :..:|::.|||..|
Human   196 YLPVIIMTVLYWHI--------------------------------------------------- 209

  Fly   371 ELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAE 435
                                                       .|||.::|:::.|
Human   210 -------------------------------------------SRASKSRIKKDKK--------- 222

  Fly   436 KSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNS 500
                          |...||
Human   223 --------------EPVANQ--------------------------------------------- 228

  Fly   501 KSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCS 565

Human   229 ----------------------------------------------------------------- 228

  Fly   566 TLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSD 630
                                    ||:||               .|||..:..|:....|:  ||
Human   229 ------------------------DPVSP---------------SLVQGRIVKPNNNNMPS--SD 252

  Fly   631 DYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPP 695
            |               .|.::.:.|                             ||.|
Human   253 D---------------GLEHNKIQN-----------------------------GKAP------- 266

  Fly   696 ARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFA 760
              |:|...|..|...:..|.:.:...:::.|:..:.......::..::...|         ::.:
Human   267 --RDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK---------DENS 320

  Fly   761 KVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTP 825
            |   ::||                                             ::.|.||:
Human   321 K---QTCI---------------------------------------------RIGTKTPK---- 333

  Fly   826 QSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANRE 890
                                |||.|        .|::|..|.|...|:|               :
Human   334 --------------------SDSCT--------PTNTTVEVVGSSGQNG---------------D 355

  Fly   891 EKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACW 955
            ||....:|.      |..:.|....||..|              :|.:|..|||..||..|:..|
Human   356 EKQNIVARK------IVKMTKQPAKKKPPP--------------SREKKVTRTILAILLAFIITW 400

  Fly   956 TPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .||:|:.|:..||  .|||...::...|:|||.||.:||.||||.|..|||||..:|
Human   401 APYNVMVLINTFC--APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.