DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and HRH3

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:XP_005260323.1 Gene:HRH3 / 11255 HGNCID:5184 Length:453 Species:Homo sapiens


Alignment Length:412 Identity:112/412 - (27%)
Similarity:177/412 - (42%) Gaps:66/412 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 DGGSTMSGS-SSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSN 169
            ||....||: :.::...|......|.|..:|.|: :|:.|:.||.||.||:|||:.|.::|..:|
Human     7 DGPLNASGALAGEAAAAGGARGFSAAWTAVLAAL-MALLIVATVLGNALVMLAFVADSSLRTQNN 70

  Fly   170 YFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCS 234
            :|:.:||.:|.|:|...:|.|..|||.|.|..|..||.|||.|||.:|..|.:.::||:.||:.|
Human    71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLS 135

  Fly   235 VKIAAKYRSWRTRT-RVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIF-N 297
            |..|..||:.:..| |.:..:.:.|::..||:..:|..||:.:|...:..|.|..:|..:..| .
Human   136 VTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLI 200

  Fly   298 TALIIGYYWTTLIVLFV---LYAGIY-KTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAG----- 353
            ||..:.::...|.|.|.   :|..|. :|...:....||...:.......|.....|..|     
Human   201 TASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKG 265

  Fly   354 -------HAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTP 411
                   |..|:|   |..:..:   ||:.|            |.|.|....:|         :|
Human   266 HGEAMPLHRYGVG---EAAVGAE---AGEAT------------LGGGGGGGSVA---------SP 303

  Fly   412 EQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDE-ESSVNQAQQLITQQ-KLNNMRK---- 470
            .....|:::..|..:         ..:|.|.|:..|.. |..:....|..||: :|:..||    
Human   304 TSSSGSSSRGTERPR---------SLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKS 359

  Fly   471 ----RSSIGLVFGAQAALLATR 488
                .|..||.:.....|:..|
Human   360 LAVIVSIFGLCWAPYTLLMIIR 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 65/181 (36%)
TM helix 2 168..194 CDD:320429 9/25 (36%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 6/23 (26%)
TM helix 5 293..322 CDD:320429 8/33 (24%)
7tm_GPCRs <932..1008 CDD:475119
TM helix 6 941..963 CDD:410628
TM helix 7 976..1001 CDD:410628
HRH3XP_005260323.1 7tmA_Histamine_H3R 48..423 CDD:320423 101/370 (27%)
TM helix 2 69..96 CDD:320423 10/26 (38%)
TM helix 3 107..137 CDD:320423 14/29 (48%)
TM helix 4 152..170 CDD:320423 3/17 (18%)
TM helix 5 195..225 CDD:320423 7/29 (24%)
TM helix 6 351..381 CDD:320423 6/29 (21%)
TM helix 7 391..416 CDD:320423
Blue background indicates that the domain is not in the aligned region.

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