DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and chrm5

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:XP_017952476.1 Gene:chrm5 / 100498518 XenbaseID:XB-GENE-986590 Length:525 Species:Xenopus tropicalis


Alignment Length:891 Identity:177/891 - (19%)
Similarity:270/891 - (30%) Gaps:412/891 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 LPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPF 189
            |...:||:.|.||...||..::|:.|||||:::|.|:..::..:||::.|||..|::||..||..
 Frog    17 LKAHSLWEVITIATVSAIVSLITIVGNILVMVSFKVNSQLKTVNNYYLLSLACADLIIGIFSMNL 81

  Fly   190 YTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMV 254
            ||.|:|.|:|.||.:.|||||::||.....|...:|:|:.|||.|:.....||:.||..|...|:
 Frog    82 YTSYILIGHWSLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGLMI 146

  Fly   255 TITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGI 319
            .:.|.|..:|:..:|..|::|.|.|.:.|.:|.:|||.:||......|..::..:.|:.:||..|
 Frog   147 GLAWFISFILWAPAILCWQYFVGGRTVPPEECQIQFLYEPIITFGTAIAAFYLPVSVMTILYCRI 211

  Fly   320 YKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACT 384
            ||..                                       ||..|...||.|.::..|    
 Frog   212 YKET---------------------------------------EKRTKDLAELQGSESVAD---- 233

  Fly   385 TVIKRLSGSGQANPLAVATEEVEKMTPEQ---RRASAAKIQEEAKKREAAVDAEKSERSSSPAFD 446
                                 .|.|.|:.   :...:.| |:...|||.   .:.|..|||    
 Frog   234 ---------------------FEMMRPQGTLFKSCFSCK-QQTRTKRER---CQASWSSSS---- 269

  Fly   447 SDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHH 511
                                                            :|||.:..|        
 Frog   270 ------------------------------------------------RSTTTTVKI-------- 278

  Fly   512 HQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRL 576
                                              .|..|..|..:...:.|:||:.....:.|:.
 Frog   279 ----------------------------------THSPNTCNEWIKEDQLTTCSSYPSSDDEDKQ 309

  Fly   577 VDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSS 641
            .                          .:.|.||                               
 Frog   310 T--------------------------KEAVFQG------------------------------- 317

  Fly   642 GNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLN 706
                   .|:..|  |.:..:|:..:|                           .:..|..||. 
 Frog   318 -------AYENQT--EAQKEEETKQIL---------------------------TKEQPGLSNY- 345

  Fly   707 QSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAI 771
                          :|....|.|  .:..||...:.|:.:.|::|:..|.::.    ...|    
 Frog   346 --------------ESERFFLTP--GKGHSQKSPKCVSYKFRIVVNDDGSQEV----NNGC---- 386

  Fly   772 CLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVP 836
                                                     .|||              :||   
 Frog   387 -----------------------------------------RKVK--------------ITP--- 393

  Fly   837 LERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSS 901
                                                                    ..:.|:..|
 Frog   394 --------------------------------------------------------CSSMSKGHS 402

  Fly   902 KRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEG 966
            .|:...||......:|.:.||             :.|||.:|:|.||..|:..||||:::.||..
 Frog   403 LRSMDPSISHQITKRKRMVLI-------------KERKAAQTLSAILLAFIITWTPYNIMVLVST 454

  Fly   967 FCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            ||  ..||...|:...|:|||.||.:||.||||.|:.|:|||..:|
 Frog   455 FC--SDCIPSSLWHLGYWLCYVNSTVNPICYALCNKTFRKTFKMLL 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 68/175 (39%)
TM helix 2 168..194 CDD:320429 12/25 (48%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 6/22 (27%)
TM helix 5 293..322 CDD:320429 8/28 (29%)
7tm_GPCRs <932..1008 CDD:475119 34/75 (45%)
TM helix 6 941..963 CDD:410628 9/21 (43%)
TM helix 7 976..1001 CDD:410628 13/24 (54%)
chrm5XP_017952476.1 7tm_GPCRs 26..>220 CDD:475119 75/232 (32%)
TM helix 1 28..52 CDD:320427 11/23 (48%)
TM helix 2 61..83 CDD:320427 10/21 (48%)
TM helix 3 99..121 CDD:320427 9/21 (43%)
TM helix 4 144..160 CDD:320427 4/15 (27%)
TM helix 5 186..209 CDD:320427 5/22 (23%)
7tm_GPCRs <423..502 CDD:475119 38/91 (42%)
TM helix 6 429..451 CDD:320426 9/21 (43%)
TM helix 7 462..487 CDD:320426 13/24 (54%)

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