DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and chrm5

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	XP_017952476.1	Gene:	chrm5 / 100498518	XenbaseID:	XB-GENE-986590	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	891	Identity:	177/891 - (19%)
Similarity:	270/891 - (30%)	Gaps:	412/891 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPF 189
            |...:||:.|.||...||..::|:.|||||:::|.|:..::..:||::.|||..|::||..||..
Frog    17 LKAHSLWEVITIATVSAIVSLITIVGNILVMVSFKVNSQLKTVNNYYLLSLACADLIIGIFSMNL 81

  Fly   190 YTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMV 254
            ||.|:|.|:|.||.:.|||||::||.....|...:|:|:.|||.|:.....||:.||..|...|:
Frog    82 YTSYILIGHWSLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGLMI 146

  Fly   255 TITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGI 319
            .:.|.|..:|:..:|..|::|.|.|.:.|.:|.:|||.:||......|..::..:.|:.:||..|
Frog   147 GLAWFISFILWAPAILCWQYFVGGRTVPPEECQIQFLYEPIITFGTAIAAFYLPVSVMTILYCRI 211

  Fly   320 YKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACT 384
            ||..                                       ||..|...||.|.::..|
Frog   212 YKET---------------------------------------EKRTKDLAELQGSESVAD---- 233

  Fly   385 TVIKRLSGSGQANPLAVATEEVEKMTPEQ---RRASAAKIQEEAKKREAAVDAEKSERSSSPAFD 446
                                 .|.|.|:.   :...:.| |:...|||.   .:.|..|||
Frog   234 ---------------------FEMMRPQGTLFKSCFSCK-QQTRTKRER---CQASWSSSS---- 269

  Fly   447 SDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHH 511
                                                            :|||.:..|
Frog   270 ------------------------------------------------RSTTTTVKI-------- 278

  Fly   512 HQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRL 576
                                              .|..|..|..:...:.|:||:.....:.|:.
Frog   279 ----------------------------------THSPNTCNEWIKEDQLTTCSSYPSSDDEDKQ 309

  Fly   577 VDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSS 641
            .                          .:.|.||
Frog   310 T--------------------------KEAVFQG------------------------------- 317

  Fly   642 GNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLN 706
                   .|:..|  |.:..:|:..:|                           .:..|..||.
Frog   318 -------AYENQT--EAQKEEETKQIL---------------------------TKEQPGLSNY- 345

  Fly   707 QSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAI 771
                          :|....|.|  .:..||...:.|:.:.|::|:..|.::.    ...|
Frog   346 --------------ESERFFLTP--GKGHSQKSPKCVSYKFRIVVNDDGSQEV----NNGC---- 386

  Fly   772 CLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVP 836
                                                     .|||              :||
Frog   387 -----------------------------------------RKVK--------------ITP--- 393

  Fly   837 LERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSS 901
                                                                    ..:.|:..|
Frog   394 --------------------------------------------------------CSSMSKGHS 402

  Fly   902 KRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEG 966
            .|:...||......:|.:.||             :.|||.:|:|.||..|:..||||:::.||..
Frog   403 LRSMDPSISHQITKRKRMVLI-------------KERKAAQTLSAILLAFIITWTPYNIMVLVST 454

  Fly   967 FCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            ||  ..||...|:...|:|||.||.:||.||||.|:.|:|||..:|
Frog   455 FC--SDCIPSSLWHLGYWLCYVNSTVNPICYALCNKTFRKTFKMLL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	67/190 (35%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	67/185 (36%)
chrm5	XP_017952476.1	7tm_GPCRs	26..>220	CDD:391938	75/232 (32%)
		TM helix 1	28..52	CDD:341315	11/23 (48%)
		TM helix 2	61..83	CDD:341315	10/21 (48%)
		TM helix 3	99..121	CDD:341315	9/21 (43%)
		TM helix 4	144..160	CDD:341315	4/15 (27%)
		TM helix 5	186..209	CDD:341315	5/22 (23%)
		7tm_GPCRs	<423..502	CDD:391938	38/91 (42%)
		TM helix 6	426..451	CDD:341315	12/24 (50%)
		TM helix 7	462..487	CDD:341315	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920