Protein Alignment mAChR-B and chrm1

DIOPT Version :9

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: XP_004913717.1
• Gene: chrm1 / 100490434
• XenbaseID: XB-GENE-22061118
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 912
• Identity: 180/912 - (19%)
• Similarity: 280/912 - (30%)
• Gaps: 442/912 - (48%)

  Fly   110 TMSGS------SSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPS 168
            ||:.|      |:.:|...| |...|:|:.:||.|...|..::||.||:||||||.|:.:::..:
 Frog    19 TMASSTVTPLTSNATEEYDP-LGGHAVWEVVLIVITTGILSLVTVIGNVLVLLAFKVNSDLKTVN 82

  Fly   169 NYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYC 233
            |||:.|||..|::||.:||..||.|::.|.|.|||:.|||||::||.....|...:|:|:.|||.
 Frog    83 NYFLLSLACADIIIGALSMNLYTTYIVMGRWALGPVSCDLWLALDYVASNASVMNLLIISFDRYF 147

  Fly   234 SVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNT 298
            |:.....||:.||..|...|:.:.|.|..:|:..:|..|::..|:|.:....|.:||...||...
 Frog   148 SITRPLTYRAKRTPRRAAIMIGMAWFISFVLWAPAIIFWQYIVGERTVEATDCYIQFFSQPIITF 212

  Fly   299 ALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEE 363
            ...|..::..:.::.:||..:|:   :.:.||:
 Frog   213 GTAIAAFYLPVTIMIILYWRVYR---ETENRSK-------------------------------- 242

  Fly   364 KILKTKVELAGDQTDLDSACTTVIKRLSGSG---QANPLAVATEEVEKMTPEQRRASAAKIQEEA 425
                   ||||               |.|||   .::|||:.
 Frog   243 -------ELAG---------------LQGSGTDHTSHPLALG----------------------- 262

  Fly   426 KKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGK 490
                       |.||.|.: .:.|...:::.|:.:         .|:..|..|..|..
 Frog   263 -----------SVRSGSSS-GAGESERLSRGQRTV---------PRAKQGCCFPRQLT------- 299

  Fly   491 GNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPP 555
                                                |...:||...|::
 Frog   300 ------------------------------------SNPSLRSYPEHRS---------------- 312

  Fly   556 LDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPD 620
                 ..||:|:...|..|.|..
 Frog   313 -----NGSCNTMEDAASADSLSS------------------------------------------ 330

  Fly   621 AFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQG 685
                    |.:..|||:                   |::.:..:...|..|:         ||.|
 Frog   331 --------SSEAEDRPY-------------------EMKNICSAVIRLPMVS---------SVVG 359

  Fly   686 KPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLL 750
                                      ||..::..|.:|.
 Frog   360 --------------------------TPKGSRGSSDTLG-------------------------- 372

  Fly   751 VSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKV 815
                                                 |.....||:.
 Frog   373 -------------------------------------RGDIEAETNG------------------ 382

  Fly   816 KTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKK 880
                       ..:.||          |:||.:....:|||.....|                :|
 Frog   383 -----------GKSEVT----------RKTSRAQVTALPSTIIRAKS----------------EK 410

  Fly   881 NAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTIS 945
            |                              |.             |::||.|..:.:||.:|:|
 Frog   411 N------------------------------HH-------------GKRKSNSLIKEKKAAKTLS 432

  Fly   946 FILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTR 1010
            .||..|:..||||:::.||..||  |.|:.:.|:...|:|||.||.:||.||||.|:.|::||..
 Frog   433 AILLAFILTWTPYNIMVLVSTFC--PDCVPKKLWELGYWLCYVNSTVNPMCYALCNRSFRRTFKM 495

  Fly  1011 IL 1012
            :|
 Frog   496 LL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	66/190 (35%)
		7tm_4	150..>336	CDD:304433	66/185 (36%)
chrm1	XP_004913717.1	7tmA_mAChR_M1	48..493	CDD:341356	168/876 (19%)
		TM helix 1	49..75	CDD:341356	14/25 (56%)
		TM helix 2	82..108	CDD:341356	13/25 (52%)
		TM helix 3	120..150	CDD:341356	14/29 (48%)
		TM helix 4	162..185	CDD:341356	6/22 (27%)
		TM helix 5	207..236	CDD:341356	6/31 (19%)
		TM helix 6	422..452	CDD:341356	12/29 (41%)
		TM helix 7	461..486	CDD:341356	13/24 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920