DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and chrm2

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	XP_002942846.2	Gene:	chrm2 / 100485603	XenbaseID:	XB-GENE-6034896	Length:	470	Species:	Xenopus tropicalis

Alignment Length:	924	Identity:	166/924 - (17%)
Similarity:	268/924 - (29%)	Gaps:	467/924 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 VNNTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVL 155
            :||::|:    |.||. ..||.||            |:...:.:.|.|......::|:.|||||:
Frog     1 MNNSSLV----NVSST-NETMMGS------------PYKTVEVVFIVIVAGSLSLVTIIGNILVM 48

  Fly   156 LAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVS 220
            ::..|:|:::..:|||:.|||..|::||..||..||:|.:.|||.:||::|||||::||.|...|
Frog    49 VSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPIGPVVCDLWLALDYVVSNAS 113

  Fly   221 QYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQ 285
            ...:|:|:.|||..|.....|...||......|:...|::..:|:..:|..|:...|.|.:..|:
Frog   114 VMNLLIISFDRYFCVTKPLTYPVRRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEGE 178

  Fly   286 CAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSG 350
            |.:||..:........|..::..:|::.|||..|
Frog   179 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWQI------------------------------- 212

  Fly   351 MAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRR 415
                                                                           .|
Frog   213 ---------------------------------------------------------------SR 214

  Fly   416 ASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGA 480
            ||.::|::  .|:|||
Frog   215 ASKSRIKK--GKKEAA------------------------------------------------- 228

  Fly   481 QAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHH 545

Frog   229 ----------------------------------------------------------------- 228

  Fly   546 QHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQG 610
                  ||                                   .||:||.::           ||
Frog   229 ------PN-----------------------------------QDPISPSNV-----------QG 241

  Fly   611 LVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANS 675
            .:.                     :|..|:...:|..|.:..:.|.:             ||:||
Frog   242 KIV---------------------KPNNNNVAANEDGLDHGKIQNGK-------------VTSNS 272

  Fly   676 TTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIE 740
            ........:|:...:            ||.:.|:|...::::..::.:     |..:.||
Frog   273 GIENCVQAEGEEKEI------------SNDSTSVSVVNTKDEGAAKDV-----PQASGSQ----- 315

  Fly   741 EAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSP 805
                                                             ::|...:||...:
Frog   316 -------------------------------------------------ANPKTENSKLTCI--- 328

  Fly   806 MPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGG 870
                    ::.|.:|: |...:|.|.|..:                 :|..:|
Frog   329 --------RIVTKSPK-GDCSNATGTTVEI-----------------VPGANG------------ 355

  Fly   871 EQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKS--KKALPLILGVGGRQKSKS 933
                            .|.|:|....:|         .|.|..|.  ||.||
Frog   356 ----------------RNGEDKQNIVAR---------KIVKMTKQPPKKKLP------------- 382

  Fly   934 ENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYA 998
            .:|.:|..|||..||..|:..||||:|:.|:..||  ..|:...::...|:|||.||.:||.|||
Frog   383 PSREKKVTRTILAILLAFIITWTPYNVMVLINTFC--AVCVPNTVWTIGYWLCYINSTINPACYA 445

  Fly   999 LANQQFKKTFTRIL 1012
            |.|..|||||..:|
Frog   446 LCNTTFKKTFKHLL 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	61/190 (32%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	61/185 (33%)
chrm2	XP_002942846.2	7tmA_mAChR_M2	27..455	CDD:320424	152/875 (17%)
		TM helix 1	29..53	CDD:320424	8/23 (35%)
		TM helix 2	62..84	CDD:320424	11/21 (52%)
		TM helix 3	100..122	CDD:320424	10/21 (48%)
		TM helix 4	145..161	CDD:320424	3/15 (20%)
		TM helix 5	187..210	CDD:320424	4/22 (18%)
		TM helix 6	390..412	CDD:320424	11/21 (52%)
		TM helix 7	423..448	CDD:320424	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920