DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mAChR-B and chrm4a

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:XP_001922442.1 Gene:chrm4a / 100150701 ZFINID:ZDB-GENE-090410-6 Length:513 Species:Danio rerio


Alignment Length:928 Identity:186/928 - (20%)
Similarity:281/928 - (30%) Gaps:439/928 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 WYRNFDVNNTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVG 149
            |..|..::|.:   :..|.|.|.||. :||.:..|  |....|:...:.:.||:.......:||.
Zfish    15 WNFNGSLSNVS---SDANFSCDSGSA-NGSCAAVE--GDGESPYKTVEMVFIALVTGSLSFVTVV 73

  Fly   150 GNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDY 214
            |||||:|:..|:|:::..:|||:.|||..|::||..||..||:|::||||.|||::|||||::||
Zfish    74 GNILVMLSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGPVVCDLWLALDY 138

  Fly   215 TVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKR 279
            .|...|...:|:|:.|||..|.....|.:.||......|:...||:..:|:..:|..|:...|.|
Zfish   139 VVSNASVMNLLIISFDRYFCVTKPLSYPTRRTTKMAGLMIASAWILSFILWAPAILFWQFIVGAR 203

  Fly   280 DLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALS 344
            .:.||:|.:|||.:|.......|..::..::::.|||                            
Zfish   204 TVAPGECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLY---------------------------- 240

  Fly   345 AGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKM 409
                                   ..:.||.                                   
Zfish   241 -----------------------VHISLAS----------------------------------- 247

  Fly   410 TPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSI 474
                 |:..:|.:.||||.:.|                                           
Zfish   248 -----RSRVSKQKPEAKKEKKA------------------------------------------- 264

  Fly   475 GLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQN 539
                               |||:...||       |..:|:::||||                  
Zfish   265 -------------------QKSSGLLKS-------HILKQNNNNQSP------------------ 285

  Fly   540 QQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPS 604
                        |.|.||     :|||:                                     
Zfish   286 ------------PKPSLD-----TCSTV------------------------------------- 296

  Fly   605 DQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLA 669
                                                          |.|.|.:|.....|:...:
Zfish   297 ----------------------------------------------DTMKNGKLEESVVSAKADS 315

  Fly   670 SVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQS 734
            .|.|....|.|||  ....:.|..|..|.|   |.:......||:...:|      .|||....|
Zfish   316 CVQAEEKESSNDS--STASIAPKEPKERAN---SEVTSDAGLTPAPAAAP------KLNPQSKWS 369

  Fly   735 QSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKD 799
            :                    |:...|...:.||.||.::                         
Zfish   370 K--------------------IKIVTKQAGDECITAIEIV------------------------- 389

  Fly   800 AILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTG 864
                                     |.::.|.:..:|:.|              |.|        
Zfish   390 -------------------------PPNSTGESRSIPVSR--------------PRT-------- 407

  Fly   865 GVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQ 929
                                  ..|:..|:|.|:...||                          
Zfish   408 ----------------------VARKFASIARSQVKRKR-------------------------- 424

  Fly   930 KSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNP 994
              :...|.:|..:||..||..|:..||||:|:.|:..||:  .|:.:.::...|:|||.||.:||
Zfish   425 --QMAAREKKVTKTIFAILLAFIITWTPYNVMVLISTFCQ--SCVPDTVWAIGYWLCYVNSTINP 485

  Fly   995 FCYALANQQFKKTFTRIL 1012
            .||||.|..|||||..:|
Zfish   486 ACYALCNATFKKTFKNLL 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 68/175 (39%)
TM helix 2 168..194 CDD:320429 13/25 (52%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 5/22 (23%)
TM helix 5 293..322 CDD:320429 5/28 (18%)
7tm_GPCRs <932..1008 CDD:475119 32/75 (43%)
TM helix 6 941..963 CDD:410628 10/21 (48%)
TM helix 7 976..1001 CDD:410628 12/24 (50%)
chrm4aXP_001922442.1 7tmA_mAChR_M4 58..499 CDD:341344 170/873 (19%)
TM helix 1 59..85 CDD:341344 10/25 (40%)
TM helix 2 92..118 CDD:341344 13/25 (52%)
TM helix 3 130..160 CDD:341344 14/29 (48%)
TM helix 4 172..195 CDD:341344 5/22 (23%)
TM helix 5 217..246 CDD:341344 5/79 (6%)
TM helix 6 428..458 CDD:341344 13/29 (45%)
TM helix 7 467..492 CDD:341344 12/24 (50%)

Return to query results.
Submit another query.