DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and chrm4

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:XP_031755648.1 Gene:chrm4 / 100127705 XenbaseID:XB-GENE-5872073 Length:505 Species:Xenopus tropicalis


Alignment Length:930 Identity:181/930 - (19%)
Similarity:273/930 - (29%) Gaps:461/930 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 WYRNFDVNNTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVG 149
            |.:..: |.||    ..||:.|..:...|:....|:             |.||.......::||.
 Frog    24 WLQEME-NMTN----ATNQTLDKTTMAPGTYQTMEM-------------IFIATVTGSLSLVTVV 70

  Fly   150 GNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDY 214
            |||||:|:..|:|.::..:|||:.|||..|::||..||..|::|::||||.|||::|||||::||
 Frog    71 GNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYSLYIIKGYWPLGPIVCDLWLALDY 135

  Fly   215 TVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKR 279
            .|...|...:|:|:.|||..|.....|.:.||......|:...|::..:|:..:|..|:...|:|
 Frog   136 VVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWLLSFVLWAPAILFWQFIVGER 200

  Fly   280 DLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKR--SEAKQRKMQSMVA 342
            .:..|:|.:|||.:|:......|..::..::::.:||..|...:....:|  :|.:|.|.:.:  
 Frog   201 TVASGECYIQFLSNPVVTFGTAIAAFYLPVVIMTILYIHISLASRSRVRRHCTETRQEKKKPI-- 263

  Fly   343 LSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVE 407
                                                              |...:||...|:.:.
 Frog   264 --------------------------------------------------SSMKSPLIKQTKNLP 278

  Fly   408 KMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRS 472
            |..|          .:||.|:|                                    |.:|   
 Frog   279 KQDP----------GDEAVKKE------------------------------------NGVR--- 294

  Fly   473 SIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHH 537
                             .|.::||.||                      ||.|:.||.       
 Frog   295 -----------------NGKIEKSMTN----------------------LQTAEEKET------- 313

  Fly   538 QNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEV 602
            .|:.......|    |||..:|                            .||..|.|.|||   
 Frog   314 SNESSSASLSH----NPPEKQP----------------------------VSDASSGVVLAP--- 343

  Fly   603 PSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAM 667
                                                                             
 Frog   344 ----------------------------------------------------------------- 343

  Fly   668 LASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHN 732
                           .|..||:          |.|.|:....|:.                    
 Frog   344 ---------------TQNMPPL----------PSKVNVASKWSKI-------------------- 363

  Fly   733 QSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSS 797
                           :::...||.|         |:.||       ::..:|             
 Frog   364 ---------------KIVTKQTGNE---------CVTAI-------EIVPEC------------- 384

  Fly   798 KDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSS 862
                      .:||             ||.|                      |..|        
 Frog   385 ----------AIPL-------------PQQA----------------------NNRP-------- 396

  Fly   863 TGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGG 927
                                    .|...|..:.:||..                          
 Frog   397 ------------------------GNVARKFASIARNQV-------------------------- 411

  Fly   928 RQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPM 992
            |:|.:...|.:|..|||..||..|:..||||:|:.|:..||:  .||.|.::...|:|||.||.:
 Frog   412 RKKRQMAAREKKVTRTIFAILLAFIITWTPYNVMVLINTFCQ--TCIPETVWYIGYWLCYVNSTI 474

  Fly   993 NPFCYALANQQFKKTFTRIL 1012
            ||.||||.|..|||||..:|
 Frog   475 NPACYALCNATFKKTFKHLL 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 65/175 (37%)
TM helix 2 168..194 CDD:320429 12/25 (48%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 4/22 (18%)
TM helix 5 293..322 CDD:320429 5/28 (18%)
7tm_GPCRs <932..1008 CDD:475119 35/75 (47%)
TM helix 6 941..963 CDD:410628 11/21 (52%)
TM helix 7 976..1001 CDD:410628 13/24 (54%)
chrm4XP_031755648.1 7tmA_mAChR_M4 55..490 CDD:341344 169/875 (19%)
TM helix 1 56..82 CDD:341344 10/25 (40%)
TM helix 2 89..115 CDD:341344 12/25 (48%)
TM helix 3 127..157 CDD:341344 14/29 (48%)
TM helix 4 169..192 CDD:341344 4/22 (18%)
TM helix 5 214..243 CDD:341344 5/28 (18%)
TM helix 6 419..449 CDD:341344 14/29 (48%)
TM helix 7 458..483 CDD:341344 13/24 (54%)

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