DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11035 and DNAJC8

DIOPT Version :9

Sequence 1:	NP_001303469.1	Gene:	CG11035 / 40953	FlyBaseID:	FBgn0037544	Length:	231	Species:	Drosophila melanogaster
Sequence 2:	NP_055095.2	Gene:	DNAJC8 / 22826	HGNCID:	15470	Length:	253	Species:	Homo sapiens

Alignment Length:	164	Identity:	40/164 - (24%)
Similarity:	78/164 - (47%)	Gaps:	19/164 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SQRHQMSHYDALGIRRQCTQNEIKAAYYKLSMLYHPDRNQ-GSENAAKKFREINQAYE-ILGNYR 83
            |....::.::.|.|..:.|..|||..:.:||:|.|||:|| .::.|.|.|..:::||: :|...:
Human    51 SSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQ 115

  Fly    84 LRRLYDKGIVHTAGAQYAQDVHDVAE----------PVVEDDAETKFYKSRFQKSRVSDSAGRTP 138
            .:|..|   |..||.:|.:  |.|.|          |.:.::.:.:.:|....|..:...| ...
Human   116 KKRALD---VIQAGKEYVE--HTVKERKKQLKKEGKPTIVEEDDPELFKQAVYKQTMKLFA-ELE 174

  Fly   139 IYDFDEWSRNHYGKSFDRRQAAQAKYDRIKVQRE 172
            |...:..::..:.:...|.:..:|: ::.|.:||
Human   175 IKRKEREAKEMHERKRQREEEIEAQ-EKAKRERE 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11035	NP_001303469.1	DnaJ	26..>89	CDD:223560	21/64 (33%)
CG11035	NP_001303469.1	DnaJ	27..89	CDD:278647	21/63 (33%)
DNAJC8	NP_055095.2	CbpA	51..>238	CDD:225124	40/164 (24%)
		DnaJ	57..112	CDD:99751	19/54 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..253		5/28 (18%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	189..192		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	203..206		1/2 (50%)
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000269\|PubMed:27133716	232..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910