Protein Alignment CG2747 and SWEETIE

DIOPT Version :9

• Sequence 1: NP_001262364.1
• Gene: CG2747 / 40950
• FlyBaseID: FBgn0037541
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: NP_001185337.1
• Gene: SWEETIE / 843034
• AraportID: AT1G67140
• Length: 2222
• Species: Arabidopsis thaliana
• Alignment Length: 2239
• Identity: 504/2239 - (22%)
• Similarity: 887/2239 - (39%)
• Gaps: 448/2239 - (20%)

  Fly    71 PVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPGPPIRKLIASALATLFSVGDTFM 135
            |:...|.|..|..|:....|..:..:|:|....|...:......|:|.|.:.|:|.:.|.||:..
plant    36 PLLCFEILSDLISAIDEEPKESLLVTQRKCEDALYSLVTLGARRPVRHLASVAMAKIISNGDSIS 100

  Fly   136 LFDTVNACNDILKNKDDSPSYLPTKL--AAICVLGSMYEKLGRMMGRTYEDTVQILIRTLRNAES 198
            ::...::....|.:...|.   |.::  ||.| ||.:|...|:.:.....:|..|:.:.::..|.
plant   101 IYSRASSLQGFLSDGKRSD---PQRVAGAAQC-LGELYRHFGKKITSGLFETTSIVTKLVKFNED 161

  Fly   199 QARIEIMHTLEKVSAGM-GTAIANVHKDIYK-AAKHCLLDRVMAVRVAAARCILKMI--YSAPFL 259
            ..|.|....|.....|. |||.|..:.:.|: ..:...||:...||:||||| ||..  ...|.|
plant   162 FVRQEAFILLHNALEGCGGTAAATAYSEAYRLITRFSTLDKSFVVRIAAARC-LKAFSNIGGPGL 225

  Fly   260 YQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKKKQGQAVAIQAGKGATQ 324
            ..:|.::|.:.|.:..:.|...||.|.|:.||:|||.... .||....:.:|.....:..:|..|
plant   226 GTSEFDTLASYCVKGIEDSESSVRDAFAEALGSLLALGMH-PEAHVQPRGKGPFPPAKKLEGGLQ 289

  Fly   325 RLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAYVVFVQFMGSVWL--ER 387
            |.:.|                .|.|..|...|.:       |.|:..::|.|:|.:...:|  :.
plant   290 RHLIL----------------PFTKAVGSRAKNT-------RFGLALSWVFFLQAIRIRYLDSDS 331

  Fly   388 QLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQSAACKELVHLVAKQMN 452
            :|..:...::|::...    |.:|| ::..|:.:|||..:...:.|.:|    :.....:.||:.
plant   332 ELQDYSLPIMDMLRGD----SSIDA-HALACVLYILRVGVIDQMMEPSQ----RSFSVFLGKQLQ 387

  Fly   453 SIDFNPENAKDSNQETLFSQHLLVCALQELSSLLIGLGTTAQNLLGDQSLQAIDATC-AVLVHPC 516
            |.:.:|.              :.:.||:.||..|..||....     :..:..|.|. |.|.|..
plant   388 SSNASPS--------------MKIVALRALSYTLKTLGEVPH-----EFKEFFDDTVGAALSHFL 433

  Fly   517 AAARLAAAWCLRCACVAVP---GQITPLIDRFVEAI---------EQMRSSPEAMAGYSCALAAI 569
            ...|:.||..||......|   |.:|......:.|:         :::::...::.|.:..|||:
plant   434 DLVRVEAALTLRALAEVDPTCVGGLTSFAVTTLNALRESLSFEKGDKLKTDLASLHGQAATLAAL 498

  Fly   570 LGSVRYSP---LGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLGSPVVKGL 631
               |..||   ||.|....:.|...::::|..:.:|..::....:|||||:.:::        ..
plant   499 ---VSISPGLSLGYPARLPRSVLEVSKKMLTESRRNVTVASSEKEAGWLLLSSLL--------NS 552

  Fly   632 LPR---------MLLLWRNSFPRSNKELESEKA--RGDAFTWQVTLEGRAGALSVMHSFLLNCPD 685
            :|:         :|:||.:.|..:.:.|..::|  :.....|...::    ||:......::|.|
plant   553 MPKEEFGDQDFDILILWTDVFAGNPEHLIKQQAELKSMLSVWSAAID----ALTAFVRRFVSCND 613

  Fly   686 LLNEDITRRLLTPIESALAMLVNLASVLKSYGT-------QLKAPAAMVRLRLFETLTLLP-ANA 742
            .:       ||.|:      |.||.|.|....|       .:|....::.:|:......:| ..|
plant   614 GI-------LLQPV------LANLRSALSCVSTMANKRFSDVKTLVDILIIRILIAYQSIPDPLA 665

  Fly   743 LEASYTHLLRMLVSEFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVD 807
            .::.:..::::..:.:  .|.:....:|.|::|....|: .||.|:  ......||::
plant   666 YKSEHQQIIQLCTTPY--RDPSGFEESSCLKSLLDKRDA-WLGPWI--PGRDWFEDEL------- 718

  Fly   808 GEHLQPNSAAGSGALEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPG 872
             .:.|                                      ||.:|...|..:  ||....|.
plant   719 -RYFQ--------------------------------------GGEDGLAPSVWE--SKVSSFPL 742

  Fly   873 PLPLGVAVIDMAVTLYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQM-NIFTALLCALKN 936
            |..:...:::..|..:|.:|....::..|.:|....:|::..|..:.....: ||...||..||.
plant   743 PETVKKTLVNQMVLCFGIMFASQDSQGMLSLLSVIQQCLKAGKKQQWRTASLTNICAGLLAGLKA 807

  Fly   937 LTDSKTSLGQEDVRKSATALIVASLTSAN--STIRCAAGEALGRLAQVVGDSHFTAELAQNSFDK 999
            |...:......:|..|..|:....||..:  ::.|.||.|.||.||: :|:..|||.:.:.....
plant   808 LHALRPQQLTTEVLSSGQAIFQNILTEGDICASQRRAACEGLGLLAR-LGNDIFTARMTRVLLGD 871

  Fly  1000 LKSARDVVTRTGHSHALGCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIAD 1064
            |....|.......:.||||:|...|||..|..:..:|:.:.:|.:.|... ::.|:|:.|....:
plant   872 LSGVTDPNYGGSIALALGCIHHSAGGMALSSLVPATVNSVSSLTKTSVLG-LKIWALHGLLLTIE 935

  Fly  1065 SGGPMFRGYVEATLTLCLKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFL 1129
            :.|..|..:|:|.|.|.|.:|||.....:|:.|.:||::||::..:||||.         .||.|
plant   936 AAGLSFVSHVQAALGLALDILLTEESGWIDLSQGIGRLINAIVAVLGPELS---------PGSIL 991

  Fly  1130 ---CSAAL--LQSHSDPLVQAEAIGCLQQLHLFASKSLQLEELVPTLVGMLACNYFILRKASVSC 1189
               |.:.:  :.|..:.....|::...|||.|||.:::.:...|..|:..||....|:|:.|||.
plant   992 FSRCKSVIAEISSWQEIPTLLESVCFTQQLILFAPQAVSVHIHVKNLLMTLASRQPIIRRLSVST 1056

  Fly  1190 LRQLAHREAKEVCELALTINAEQLPDLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQML 1254
            ||.|..::...|.:       ||:.|          .||.:||.|||:|:...|..||..:|...
plant  1057 LRHLVEKDPVSVID-------EQIED----------NLFQMLDEETDSEIGNLIRSTLIRLLYAT 1104

  Fly  1255 AADNLSSWLSLCKNVLTVAVEGGLNDDPAAGEQ--SKSKEAGGEDDEEDEEEEYADDVTEYRAEE 1317
            .....|.|:.:|:| :.:|...|.:.:.:..|.  :.::|..|:|||:.........:.....::
plant  1105 CPSRPSRWMLICRN-MALAASAGRSAETSIAENDPAYTRENLGDDDEDMVSSSSGKSIRANPDKD 1168

  Fly  1318 NTSTHPAVQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIR-SRGDYLILHLAELIR 1381
            .|.       |:.||||||:|: .::.......:.|||:|.|:.....| |.||:|:|.|.|||.
plant  1169 KTL-------RYRTRVFAAECL-SLLPEAVGNDAAHFDILLARNLASNRQSSGDWLVLQLQELIS 1225

  Fly  1382 MSFMAATSDSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHV 1446
            :::..:|...:.:|..|:..|..|:::|..|.:||.||||||||:|||:.:|:|.|...::...:
plant  1226 LAYQISTIQFENMRPIGVGLLSTILEKFKLVADPELPGHLLLEQYQAQLLSAVRTALDANSGPVL 1290

  Fly  1447 TAAACEVCSAWIGSGVAR-DIGDLKRVHQLLVSSLDKLSSKTNSTQLYNESMA----TLEKLSIL 1506
            ..|..::.:..:.||:.| |...:||:..||...|:..:      :||..|.|    :..|:.:|
plant  1291 LEAGLQLATKIMTSGIIRSDQVAVKRIFSLLSRPLNDFN------ELYYPSFAEWVTSKIKIRLL 1349

  Fly  1507 KAWAEV--YIVAMI--GNGKAPASLLNLQSQQSGFQSLTNLETDSDVPDSRGESLLGLVQPELHN 1567
            .|.|.:  ||...:  .:|:.|...                           |:||.:.......
plant  1350 AAHASLKCYIFTFLRKHHGEVPVEF---------------------------EALLPMFSKSSDL 1387

  Fly  1568 LSTHWLSAMKDHALLLLPAEFQSQ-------LPHDGGAFYTTDTINSS-KPHYMTSWPPILYASA 1624
            |..:|:..:|.::.:.|....:..       |||         |::.. :|....:||.||.|..
plant  1388 LGRYWIQVLKGYSYICLCQNLKKSCSFLDEILPH---------TVSRRLQPCLEEAWPVILQALV 1443

  Fly  1625 LWLRDEGFARHL--DTSEAAAESNNNQITHGSLSADRFHMIFGICMEAL---------------- 1671
            |   |.....|.  :.|:.:..|.:..:|   |.|:.|..::|..:..|
plant  1444 L---DAIPVNHSVEEFSDRSLISTHRMVT---LEAEDFQFLWGFAVLVLFQGMHPASSMQVIPFS 1502

  Fly  1672 -CSMRSSERPRNIVSCLRSLH------SIFDSDWARRQLVKDRALTIELCHVLHRQILTRD---E 1726
             ..::||.......|..:.|.      .:|.|..|.| ......|:|:||..| .|:|:..   :
plant  1503 SAKIKSSGDSSINESSFQGLKLYEIALPVFQSLSAGR-FFSSGFLSIDLCQEL-LQVLSYSFHMD 1565

  Fly  1727 LLVQLLCVEILKQTIRAAREDLERKRDDNANSEDGKGGERHGEDDSMQPGSSHVYAVLEVCLCLF 1791
            ....:|.|.:::|..:...:|.       ..||:                  ..|:.:|:||...
plant  1566 SSWDILAVSVVQQISQNCPKDF-------LESEE------------------FAYSTIELCLGYL 1605

  Fly  1792 VRQIPTMNPTRQGAGGSGLQLDFAYAKMATGSSFFSV---LGDENGLLVSSGLQCVEQL-MDLCT 1852
            .:.:...|......|.....|...:..:.|....|.:   |.......:.||.:|:.|: .|...
plant  1606 FKILHRHNEISPDDGIWDNMLSPLFISIKTLVKRFELKHRLNSAPLAFLLSGYKCIRQVPTDAYL 1670

  Fly  1853 PKGALAILPTVLYMTTSIVKEIANKSAIDSTILA-----NTCAVKSALQCLRSV------CVHKW 1906
            || ||.|:.:...:...:.:..:.|...|.|..|     :..|:..|  ||..|      |::..
plant  1671 PK-ALEIVKSTNDLLLELTRASSQKPYTDGTNFAADSGFHLRAIFGA--CLHMVGDLTRDCINGI 1732

  Fly  1907 AKVEETTEEWQQLLQSALATIVDLTKTAGDNEERKVDEVTMLLAITVFILHTPASVVATPSLQYP 1971
            ..|:......::|||..|...:               |....||...:....|.....|.|:
plant  1733 QLVDSKRSGLRKLLQLKLVFCL---------------EQLFSLAKLAYEFDCPVDETNTNSI--- 1779

  Fly  1972 CINHFRQC-------LQSENLSVKLRCIETTRSIFARAELKTATPYIHALAPRIIESLYAESSKV 2029
            ||...:.|       ::..|:.|:...::..:|:..|........::......:|..:.   |.:
plant  1780 CIVMLKSCQISIAAVVKDSNVQVQATVLQVLKSLVQRYNNPEEKSFVILFVGELIGDIV---SLM 1841

  Fly  2030 PTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQ------DIQ--MLTLLVPVLI--------G 2078
            ..:.|...|..||:|...:.:       |.:.|||      ::|  .::|.:.|::        |
plant  1842 QRALLVKPVNTESVVIAGECL-------RFIMLLQTHSITDELQKGFMSLFLEVVLVVFSKTSDG 1899

  Fly  2079 FLAEPSRLRT----LPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPEL-RQKLEAAIRSQQQ 2138
            ...|...||.    |..:..||...|:            .||.::...|.. ||:|:..||
plant  1900 VSQEVLELRNVAVRLVSHLAQLPSSAV------------HFKDVLLSLPVTHRQQLQDIIR---- 1948

  Fly  2139 SINIAQKASEAQRNLLAKPQK--PTIKLK 2165
                   ||.::.:.||||:.  |.:.:|
plant  1949 -------ASVSKDSALAKPKSLVPAMDIK 1970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	9/29 (31%)
		HEAT repeat	185..213	CDD:293787	6/27 (22%)
		HEAT repeat	225..255	CDD:293787	12/32 (38%)
		HEAT repeat	266..292	CDD:293787	8/25 (32%)
SWEETIE	NP_001185337.1	HEAT repeat	103..135	CDD:293787	8/35 (23%)
		HEAT repeat	147..181	CDD:293787	7/33 (21%)
		HEAT repeat	192..216	CDD:293787	10/24 (42%)
		HEAT repeat	230..259	CDD:293787	9/28 (32%)
		Ehrlichia_rpt	1894..>2216	CDD:118064	24/100 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	307	1.000	Domainoid score	I321
eggNOG	1	0.900	-	-		E1_KOG1822
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I753
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D71064at2759
OrthoFinder	1	1.000	-	-		FOG0001774
OrthoInspector	1	1.000	-	-		oto3441
orthoMCL	1	0.900	-	-		OOG6_102302
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1302
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770