Protein Alignment CG2747 and HEATR5B

DIOPT Version :10

• Sequence 1: NP_001262364.1
• Gene: CG2747 / 40950
• FlyBaseID: FBgn0037541
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: NP_061897.1
• Gene: HEATR5B / 54497
• HGNCID: 29273
• Length: 2071
• Species: Homo sapiens
• Alignment Length: 2188
• Identity: 1070/2188 - (48%)
• Similarity: 1448/2188 - (66%)
• Gaps: 186/2188 - (8%)

  Fly    49 MELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPG 113
            |||||:|:|||:||.|:.|.|||||..||||:|:|.|...:|.::|..|||||:||:..|..:||
Human     1 MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPG 65

  Fly   114 PPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMM 178
            ||.|||:|..||.|:|:||||.:|.|::.||||::||||:.:||||||||:..:|:.|||:|||:
Human    66 PPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRML 130

  Fly   179 GRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRV 243
            |..:.:||..|:::|::||||.|.||:.:|:||.:|:|.|.|:.|:||||.|:..|.||.||||.
Human   131 GSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRC 195

  Fly   244 AAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKK 308
            |.|:|:|::...|.|::..|||::.||||:|.:.|||.||.||::||||::| |..:.:.||
Human   196 AVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMA-TALMPKQAT--- 256

  Fly   309 KQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAY 373
                 |..|..|.||     .||.|.::.:||||||:.|||..||::|....||||||||||.||
Human   257 -----VMRQNVKRAT-----FDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAY 311

  Fly   374 VVFVQFMGSVWLERQLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQSA 438
            ||||..:|..||||..:|||:||||||::|:|..:||:|||||:|:|||||:|:|.:||||||.|
Human   312 VVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIA 376

  Fly   439 ACKELVHLVAKQMNSI-----DFNPENAKDSNQETLFSQHLLVCALQELSSLLIGLGTTAQNLLG 498
            |.||:...:.|||.::     |.:.|| |....:...|||::|||||||.||:..|..||..|:.
Human   377 AAKEICQAIGKQMKAVEAVVNDTSGEN-KSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQ 440

  Fly   499 DQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAMAGYS 563
            :.|:..::...:||:||..||||||||||||..||:|.|:||.:||..|.:..:::||||::|||
Human   441 EASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYS 505

  Fly   564 CALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLGSPVV 628
            .|:||:||.|...||||||.|||:|.:.||:|||:|:||||:||.||||||||:||:||||..||
Human   506 FAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVV 570

  Fly   629 KGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLNEDITR 693
            :..||:|||||||.||||.||||:||||||:||||||||||||||..|.||:.:||:||.||:.|
Human   571 RYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIR 635

  Fly   694 RLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRMLVSEF 758
            :|:||||.|:.|:.::.||:|::|..|||.||||||||::.|.|||....|.|:..|||.||:||
Human   636 KLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEF 700

  Fly   759 TLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAGSGALE 823
            ||:||:||||.||||:|||.|||::||:|||||:|::||||           ||||||:||||||
Human   701 TLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQ-----------LQPNSASGSGALE 754

  Fly   824 HDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDMAVTLY 888
            |||..:|                               .:|...:..||||||||:|||.:|.|:
Human   755 HDPSSIY-------------------------------LRIPAGEAVPGPLPLGVSVIDASVALF 788

  Fly   889 GTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQEDVRKSA 953
            |.:||.|:.|||||||:||.||::|||..||:|||:|||||:|.|||.|.::|::||.|:|||||
Human   789 GVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSA 853

  Fly   954 TALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHSHALGC 1018
            ..|::..|.:.|..:||||||||||:|||||::.|.|.:||.||||||||||||:|||||.||||
Human   854 LTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGC 918

  Fly  1019 LHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATLTLCLK 1083
            |||||||:||.|||.|||||||||.||..||.||.|||::||.|.||.|||:|||||.||:|.|.
Human   919 LHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLT 983

  Fly  1084 LLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLVQAEAI 1148
            ||||||.:|.:||||:||.:.|:||||||||||.|...:|:|.|.|...|:.|.|||.||||.||
Human   984 LLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAI 1048

  Fly  1149 GCLQQLHLFASKSLQLEELVPTLVGMLACNYFILRKASVSCLRQLAHREAKEVCELALTI----- 1208
            .||||||:||.:.:.|..|||:|...|..::.:||:|:|:||||||.|||.||||.|:::
Human  1049 SCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTG 1113

  Fly  1209 -----NAEQLP----------------DLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQ 1252
                 :|...|                .:.|||.||.||||.:||.|||.::..:|||||..||.
Human  1114 DKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLS 1178

  Fly  1253 MLAADNLSSWLSLCKNVLTVAVEGGLNDDPAAGEQSKSK-EAGGEDDEEDEEEEYADDVTEYRAE 1316
            .||.:.||.||.|||:||.           |:.:.|.:. .:.|:|:|.::::|..||.......
Human  1179 SLAVEKLSHWLMLCKDVLA-----------ASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLG 1232

  Fly  1317 ENTSTHPAVQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIR 1381
            |...:.|.|.|||.||||||.|:.|||..||.|...||||..|:..:|.....|.|:|||::|||
Human  1233 EEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIR 1297

  Fly  1382 MSFMAATSDSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHV 1446
            |:|||||..|:|||:.||:.|::||.:||:|||||||||::|||:||.|||||||||:.||||.:
Human  1298 MAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDI 1362

  Fly  1447 TAAACEVCSAWIGSGVARDIGDLKRVHQLLVSSLDKL-SSKTNSTQLYNESMATLEKLSILKAWA 1510
            .|.||:|||.||||||..|:.||:|||.||||||||: :.|.:|:|||.||..|:|||::|||||
Human  1363 IAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWA 1427

  Fly  1511 EVYIVAMIGNGKAPASLLNLQSQQSGFQSLTNLETDSD----VPDSRGESLLGLVQPELHNLSTH 1571
            |||:|||         .:..:::....:::.|.:.|.|    :.:...:||:.||||||..||..
Human  1428 EVYVVAM---------NIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRL 1483

  Fly  1572 WLSAMKDHALLLLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFARHL 1636
            ||:|:||:|||.|||||.||||.|||||||.:||::::.||..||.|||:|.||||...||...
Human  1484 WLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCS- 1547

  Fly  1637 DTSEAAAES---------NNNQITH--GS------LSADRFHMIFGICMEALCSMRSSERPRNIV 1684
            :::||||.|         |.||.:.  ||      ::.||.|:|.|:.::.|||.|..|...::.
Human  1548 ESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVT 1612

  Fly  1685 SCLRSLHSIFDSDWARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLE 1749
            :||::||::.||.:||..:.:|:.:.:||..||||.:||.:...||||...:::|.:|||::.|:
Human  1613 ACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQ 1677

  Fly  1750 RKRDDNANSED---------GKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQGA 1805
            .|| :..|.:|         |:||:..|    :.||.|.|:|.:|:.:.:.||.:|.::
Human  1678 EKR-NTLNEDDMEKEACTVLGEGGDSGG----LIPGKSLVFATMELLMFILVRHMPHLS------ 1731

  Fly  1806 GGSGLQLDFAYAKMATGSSFFSV---LGDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMT 1867
                       .|::...|..:.   |.:|:..||::.:..:..|..||:|.|.:.||||:|::.
Human  1732 -----------TKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLI 1785

  Fly  1868 TSIVKEIANKSAIDSTILANTCAVKSALQCLRSVCVHKWAKVEE-TTEEWQQLLQSALATIVDLT 1931
            ..|:|:.|.||| |:.:   ...|.:|||.::|:.....||.|. ..::|..|::|.||.|::.:
Human  1786 ARILKDTAIKSA-DNQV---PPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYS 1846

  Fly  1932 KTAGDNEERKVDEVTMLLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTR 1996
            :.  ::.....|||:||.||.:|:......::...|||..|:|.|:..|.|.:..|:.:|.:...
Human  1847 QP--EDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWVQAKCYQLLL 1909

  Fly  1997 SIFARAELKTATPYIHALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMN 2061
            |:|..:....:|||||:|||.::|.|.|.....|.|.:||....|.|..:|.|:.|.|.|||
Human  1910 SVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNR--- 1971

  Fly  2062 LLQDIQMLTLLVPVLIGFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELR 2126
                :|:|.||||.||.:|.:.:...:.....:.||:.|||.|:.|||.||..||.:||..|||:
Human  1972 ----VQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELK 2032

  Fly  2127 QKLEAAIRSQQQSINIAQKASEAQRN-LLAKPQKPTIKLKTDF 2168
            .:||.|:|:.|     |.||..|.|. ..|....|||||||.|
Human  2033 VRLETAVRASQ-----ASKAKAAARQPAPAIHSAPTIKLKTSF 2070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	16/27 (59%)
		HEAT repeat	185..213	CDD:293787	14/27 (52%)
		HEAT repeat	225..255	CDD:293787	16/29 (55%)
		HEAT repeat	266..292	CDD:293787	14/25 (56%)
		Laa1_Sip1_HTR5	1371..1581	CDD:466361	117/214 (55%)
HEATR5B	NP_061897.1	HEAT repeat	97..121	CDD:293787	14/23 (61%)
		HEAT repeat	137..165	CDD:293787	14/27 (52%)
		HEAT repeat	177..207	CDD:293787	16/29 (55%)
		HEAT repeat	218..244	CDD:293787	14/25 (56%)
		HEAT 1	848..885		22/36 (61%)
		HEAT repeat	852..882	CDD:293787	16/29 (55%)
		HEAT repeat	891..921	CDD:293787	24/29 (83%)
		HEAT repeat	932..962	CDD:293787	21/29 (72%)
		HEAT 2	1062..1099		18/36 (50%)
		Laa1_Sip1_HTR5	1288..1493	CDD:466361	117/213 (55%)
		HEAT 3	1290..1327		22/36 (61%)