DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2747 and heatr5a

DIOPT Version :9

Sequence 1:	NP_001262364.1	Gene:	CG2747 / 40950	FlyBaseID:	FBgn0037541	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	XP_009291396.1	Gene:	heatr5a / 368728	ZFINID:	ZDB-GENE-030616-152	Length:	2040	Species:	Danio rerio

Alignment Length:	2171	Identity:	923/2171 - (42%)
Similarity:	1343/2171 - (61%)	Gaps:	183/2171 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPG 113
            ||.||:|:|||:|..|||||:|..|..||||:|:|.||...:|::|..||:||:||:..:..:||
Zfish     1 MEQAHSLLLNEEACSQLPEHQRAEFVFEWLRFLKKLLPATDRADVKQKQKRLVEQLTTVLTSSPG 65

  Fly   114 PPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMM 178
            ||.|.|:|..||.::.|||:.....||:.||||:::||||||:|||:|||:..||::||:|||::
Zfish    66 PPTRLLLAQCLALVYRVGDSLTSSLTVDRCNDIIRSKDDSPSFLPTRLAAVACLGALYEQLGRLL 130

  Fly   179 GRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRV 243
            ..::::|...|::.:|:||||.|.|||..:|::..|:|.:..:.|:||||||:..|.||.||||.
Zfish   131 INSFKETTTNLLKAMRSAESQGRCEIMLCVERILRGLGVSAVSCHRDIYKAARTGLTDRSMAVRC 195

  Fly   244 AAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKK 308
            |||:|:|::...|.||:.||||::.||||||.:||||:||.::::|||||||          |..
Zfish   196 AAAKCLLELQREAVFLWSTELENVATLCFRALEGSNYDVRVSISKLLGTLLA----------SAL 250

  Fly   309 KQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAY 373
            :..||:|.:.|    .:..||:|.:.:|.||||||||.||:.:|:::||:|.|:|:||||:|...
Zfish   251 EPRQAIAPRPG----SKRSSLEEVMELLSSGFLRGGAGFLRASGDMLKGTSSVSRDVRVGITQTC 311

  Fly   374 VVFVQFMGSVWLERQLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQSA 438
            ||||..:|.||||...|..|:.:::..::.:|.....|||..|.|:|||||:|:|.:||||||.|
Zfish   312 VVFVSILGGVWLETHFSRLLSLLMEWASHTRATQYPADAVSCRCCVSFILRATLGTLLGEKAQIA 376

  Fly   439 ACKELVHLVAKQMNSIDFNPENAKDSNQET-------LFSQHLLVCALQELSSLLIGLGTTAQNL 496
            |.||:..:::||...:|   .:..:.|.||       ..|||:|||||.||.||:..|.:||..|
Zfish   377 AAKEICQVISKQKRVVD---ASLHEGNMETRVSPADVAASQHVLVCALLELGSLVQDLSSTAAPL 438

  Fly   497 LGDQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAMAG 561
            |.|..:..:|...:||:||.|:||||:||||||..|.:|.|:..|:||.||.:..::|.|||:||
Zfish   439 LQDTGIGMLDTVISVLLHPSASARLASAWCLRCIAVGMPAQVAVLLDRCVERLNALKSCPEAVAG 503

  Fly   562 YSCALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLGSP 626
            ||.|:||:||:|:.|||||.|:|||:|...||:|||||:||||:|:.|||.||||:.|:.|||..
Zfish   504 YSAAIAALLGAVQLSPLGISHSKGKMVMTLAEDLLRSAAQNSRISIQRTQGGWLLLSALSTLGPT 568

  Fly   627 VVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLNEDI 691
            |::..|||:||||:.:||.|.|::|.|..|||:||||||||||||||..|.|.:::|.:||.:|:
Zfish   569 VMEHHLPRLLLLWKCAFPLSVKDVEMELRRGDSFTWQVTLEGRAGALCAMKSLVVHCKELLTDDV 633

  Fly   692 TRRLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRMLVS 756
            ..|.:..:..|:|:|..|.|::||||.|:|..|.:.:|||:|.|.||.....|.|:..:|:.|::
Zfish   634 ICRFVPLLSCAVALLTQLPSIIKSYGNQIKNAATVFKLRLYEILKLLQPKIYEESFGTVLKQLLN 698

  Fly   757 EFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAGSGA 821
            :.|..:..|....:||.:||:..|..:||..||:.:.|.||:|:.            ...:|.|.
Zfish   699 DLTGPEITACAERNLLPSLCYSQDLALLGPGLQDMDQRYIEEQLH------------GGGSGGGT 751

  Fly   822 LEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDMAVT 886
            ||:|...::                                  .|:|:.|.|||...|:...||.
Zfish   752 LEYDSFTIF----------------------------------EKSQEVPTPLPPASALTVAAVQ 782

  Fly   887 LYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQEDVRK 951
            |:|.|||.::.:.|.|:||.|.|.:||.|.:||:.||:::..|..|.||:|..|::.||.|:|::
Zfish   783 LFGVIFPHLSVQQRAQVLEQFCEFVRQLKGARQQTVQIHVTAAFFCTLKSLASSRSELGPEEVQR 847

  Fly   952 SATALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHSHAL 1016
            .|.:|::.:|..:|..:||.|.|.|.||.||:.|..||..|...||||||:|||.:|||||:.||
Zfish   848 PALSLLLGALEGSNPLLRCMAAEGLARLVQVLNDPGFTVSLTLMSFDKLKTARDAITRTGHALAL 912

  Fly  1017 GCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATLTLC 1081
            |.::||:||:.|.|:||..|.:|..|.||:.||.|:.|:|:||:.:.|..||::..::||:.||.
Zfish   913 GTVYRYLGGISSPQYLSACVGVLFTLSQDNTSPEVKMWALHALSTVVDLAGPLYHSHLEASFTLV 977

  Fly  1082 LKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLVQAE 1146
            |:|||:.||.|::|.|.:||.:|||||:|||:|||.|..|..:|.|.|...|::|...|.||||:
Zfish   978 LRLLLSTPHTHMEVQQSLGRCLNALITSVGPDLQGEGAGVCAVRTSCLVGCAVMQDSQDCLVQAQ 1042

  Fly  1147 AIGCLQQLHLFASKSLQLEELVPTLVGM---------LACNYFILRKASVSCLRQLAHREAKEVC 1202
            ||.||||||:||.:.:.|..|||:|..:         |..:|..||:|.|:||||||.|||.||.
Zfish  1043 AISCLQQLHMFAPRFVNLSSLVPSLCEILLDYSVLINLCSSYLSLRRAVVACLRQLAQREAVEVS 1107

  Fly  1203 ELALTINAEQLP-------DLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQMLAADNLS 1260
            |.|:.: .::||       |:.|.|.||.|.||||||.|:|..:.|:|.:||..|:...|...|:
Zfish  1108 EHAVAL-VKELPRRDNTQLDVTIKEVGLEGALFSLLDRESDPRLCRDIQETLVHMMSSAAESKLA 1171

  Fly  1261 SWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAEENTSTHPAV 1325
            .||.|||:||:.:.      |.||.       |..|..:|::.:.| ||.:.:.| ::.|:.|..
Zfish  1172 HWLKLCKDVLSASA------DSAAA-------ASVETQQEEDGDRY-DDSSAFHA-KSESSGPFN 1221

  Fly  1326 QPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIRMSFMAATSD 1390
            ..||.||||:.:||.||||.||...|.||::..|:||:|..|. |:|:||||:||||:|||:|..
Zfish  1222 NLRWSTRVFSMECVCRIIAQCENRDSAHFNMALAQEQRLHEST-DFLVLHLADLIRMAFMASTDH 1285

  Fly  1391 SDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHVTAAACEVCS 1455
            ||||||.||:||..||.:|:||||||||||::|||:||.|||||||||..|.|.:|||.||:|||
Zfish  1286 SDQLRLAGLQTLLVIIRKFSNVPEPEFPGHVILEQYQANVGAALRPAFHVDAPPNVTAKACQVCS 1350

  Fly  1456 AWIGSGVARDIGDLKRVHQLLVSSLDKLS-SKTNSTQLYNESMATLEKLSILKAWAEVYIVAMIG 1519
            |||.|||..|:.||:||||||.|||.|:. .:...:||||||..|:|.|::|||||||||.|:.|
Zfish  1351 AWIASGVISDLRDLRRVHQLLASSLAKVQVGRDVPSQLYNESTFTMESLAVLKAWAEVYITAVQG 1415

  Fly  1520 NGK--APASLLNLQSQQSGFQSLTNLETDSDVPDSRGESLLGLVQPELHNLSTHWLSAMKDHALL 1582
            :.:  :|.|....||:::|            .....|..||.|||.:|..||..||:|::|||||
Zfish  1416 SRQRDSPVSHQQQQSEEAG------------TAGQAGAGLLKLVQTDLATLSRLWLAALQDHALL 1468

  Fly  1583 LLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGF----------ARHL- 1636
            .||..:.|.||..||:|||.:|:..::|||.::|..||:|:||||...||          :|.:
Zfish  1469 TLPPHYSSHLPSTGGSFYTAETVEQARPHYYSAWATILHATALWLNSTGFIVVDEGPANLSRPVT 1533

  Fly  1637 DTSEAAAESNNNQITHGSLSADRFHMIFGICMEALCSMRSSERPRNIVSCLRSLHSIFDSDWARR 1701
            .||...:.|.:|..:...:::||.|:|.||.:|.|||..|.::..||.|||::|.::.:..|.|.
Zfish  1534 PTSMGQSTSLSNVKSPEDINSDRLHLILGISVEFLCSPHSGDQMENIHSCLQALQALLEVPWPRS 1598

  Fly  1702 QLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLERKR-----DDNANSED- 1760
            ::..|:||::||..:|||.|:||:...:||..:|:::|.|.||:|.:..||     ||.|..::
Zfish  1599 KVGNDQALSVELLSILHRLIVTRESPSIQLAVLELVQQIICAAQEHVREKRHSAEVDDGAAEKET 1663

  Fly  1761 ----GKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNP----TRQGAGGSGLQLDFAYA 1817
                |:|.:..|    :.||.|.|:..||:|||..||::|.::|    :..|.||....|.....
Zfish  1664 VPEFGEGRDTGG----LVPGRSLVFGALELCLCTLVRKLPQLSPKLTGSPTGRGGQTCSLSATDC 1724

  Fly  1818 KMATGSSFFSVLGDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMTTSIVKEIANKSAIDS 1882
            :                 ||:|.|..:.:|..:|:|:|::::||||||:...::|| |.|.::.:
Zfish  1725 R-----------------LVTSALAILSELPSICSPEGSVSVLPTVLYLLLGVLKE-AVKGSVGT 1771

  Fly  1883 TILANTCAVKSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLTKTAGDNEERKVDEVTM 1947
               .:...|...||.||::.....::.|::...|.||||.||.|:::...|  |..|..||||||
Zfish  1772 ---ESGQLVSGILQALRTLLTSPMSRAEKSRGAWTQLLQCALHTLLESWST--DKVEPGVDEVTM 1831

  Fly  1948 LLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTRSIFARAELKTATPYIH 2012
            |.::|:|:|:..|.|.:...||..||..||..|.|::..|..|..:...|:| :.....|.|:|.
Zfish  1832 LTSLTIFLLYASAEVTSVEPLQTRCIQTFRASLDSKDPVVLSRSYQLLLSLF-QGPAPVARPFIL 1895

  Fly  2013 ALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQDIQMLTLLVPVLI 2077
            ||..|::..|.......|....|||...::|..:|.|:..::..:|.       |::.:|:|:||
Zfish  1896 ALGGRLVSQLEEAEKSRPQGPAELQAVQDAIRALEALVFAADETHRP-------QLVAVLLPILI 1953

  Fly  2078 GFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELRQKLEAAIRSQQQSINI 2142
            ..|.:.:.|.:.|...|.||:.||:.|::|||::....||||...|.::.:||||::..|:|:|
Zfish  1954 SLLLDENALASAPAASRLLHESALRDLMRIGPQHSAVLKALMASAPHMKARLEAAVKGNQESVN- 2017

  Fly  2143 AQKASEAQRNLLAKPQKPTIKLKTDF 2168
                |:||.........|:|:||.:|
Zfish  2018 ----SKAQAPPAISKNTPSIQLKINF 2039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	17/27 (63%)
		HEAT repeat	185..213	CDD:293787	12/27 (44%)
		HEAT repeat	225..255	CDD:293787	18/29 (62%)
		HEAT repeat	266..292	CDD:293787	14/25 (56%)
heatr5a	XP_009291396.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576449
Domainoid	1	1.000	1848	1.000	Domainoid score	I4
eggNOG	1	0.900	-	-		E1_KOG1822
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1913	1.000	Inparanoid score	I55
OMA	1	1.010	-	-		QHG52955
OrthoDB	1	1.010	-	-		D71064at2759
OrthoFinder	1	1.000	-	-		FOG0001774
OrthoInspector	1	1.000	-	-		otm25547
orthoMCL	1	0.900	-	-		OOG6_102302
Panther	1	1.100	-	-	O	PTHR21663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1338
SonicParanoid	1	1.000	-	-		X1302
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800