DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2747 and HEATR5A

DIOPT Version :9

Sequence 1:	NP_001262364.1	Gene:	CG2747 / 40950	FlyBaseID:	FBgn0037541	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	NP_056288.2	Gene:	HEATR5A / 25938	HGNCID:	20276	Length:	2046	Species:	Homo sapiens

Alignment Length:	2163	Identity:	965/2163 - (44%)
Similarity:	1354/2163 - (62%)	Gaps:	161/2163 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPG 113
            |||||:|:|||:|..||.|.::..|..||||||||.|...|:.:::..||.||:||...:..:||
Human     1 MELAHSLLLNEEAYNQLGEVQKAEFIFEWLRYLEKLLLATSRNDVREKQKTLVEQLLSLLNSSPG 65

  Fly   114 PPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMM 178
            ||.|||:|..||.|:|:||||.:.:.::.|||::::||||||||||||||:..|||:|:||||::
Human    66 PPTRKLLAKNLAILYSIGDTFSVHEAIDKCNDLIRSKDDSPSYLPTKLAAVVCLGSLYKKLGRIL 130

  Fly   179 GRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRV 243
            |.|:.|||..:::.:::||||.|.|||.:|:.:..|:|.|.|..|:|:||||:.||.||.||||.
Human   131 GNTFTDTVGNILKAMKSAESQGRYEIMLSLQNILNGLGAAAAPCHRDVYKAARSCLTDRSMAVRC 195

  Fly   244 AAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKK 308
            |||:|:|::...|.|::.|:|:|:.||||::|:||||:||.:|::|||.:||       .|...|
Human   196 AAAKCLLELQNEAIFMWSTDLDSVATLCFKSFEGSNYDVRISVSKLLGIILA-------KAVISK 253

  Fly   309 KQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAY 373
            ..|.|.:.|     :.|.|||:|.|.:|.:|||||.:.||:.:|:::||:|.|:|:||||||.||
Human   254 HPGTAASRQ-----SIRRVSLEEVLELLGTGFLRGSSGFLRASGDMLKGTSSVSRDVRVGVTQAY 313

  Fly   374 VVFVQFMGSVWLERQLSTFLAHVLDLV--ANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQ 436
            ||||..:|..|||:..:.|.:|:|.|.  ::|||..:.:|||..|:|:|||||:|||.:||||||
Human   314 VVFVSTLGGAWLEKNFAAFFSHILSLASPSHPKATQTQIDAVCCRRCVSFILRTTIGGLLGEKAQ 378

  Fly   437 SAACKELVHLVAKQMNSIDFNPENAKDSNQETLF-------SQHLLVCALQELSSLLIGLGTTAQ 494
            .||.|::...:.|....:|   ....|.|.||..       |||:||||||||.:|:..|||||.
Human   379 LAAVKDICQAIWKLKKVMD---AVMSDGNLETRLGSTDVAASQHMLVCALQELGNLIHNLGTTAA 440

  Fly   495 NLLGDQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAM 559
            .||.|.|...:|:..:|::||..:.||||||||.|..||:|..:|||:||.:|.:...:|||||:
Human   441 PLLQDSSTGLLDSILSVILHPSISVRLAAAWCLHCIAVALPSYLTPLLDRCLERLTGHKSSPEAV 505

  Fly   560 AGYSCALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLG 624
            .|:|.|:||:||:|::.||||||.|||::...||:||.||:||||:|..|||||||||.|:||||
Human   506 TGFSFAVAALLGAVKHCPLGIPHGKGKIIMTLAEDLLCSAAQNSRLSAQRTQAGWLLISALMTLG 570

  Fly   625 SPVVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLNE 689
            ..||...|.|:||||:..||.|.|:||:||:|||:||||||||||||||..:.||:.:|.|||.|
Human   571 PAVVSHHLARVLLLWKCVFPASPKDLETEKSRGDSFTWQVTLEGRAGALCAIKSFVSHCGDLLTE 635

  Fly   690 DITRRLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRML 754
            ::|:|||.|:..|:.:|..|:|:||.||:.||.|:.:.|.||:|.|.|||....|.:...:||.|
Human   636 EVTQRLLPPLPCAVDLLTQLSSILKMYGSPLKTPSVVYRQRLYELLILLPPETYEGNLCAILREL 700

  Fly   755 VSEFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAGS 819
            .::.|..|.....:..||..|||.||.:||..:||||:||.||:|:          |..|..| .
Human   701 AADLTAPDIQVAASTFLLPPLCHQDDLLILSPFLQETDHRFIEEQL----------LLGNGVA-C 754

  Fly   820 GALEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDMA 884
            |:||:||..:|. :..:|:                              ..|.|||..::||..|
Human   755 GSLEYDPYSIYE-KDVEGD------------------------------SVPKPLPPALSVISSA 788

  Fly   885 VTLYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQEDV 949
            ..|:|.:...|....||.:||...:.|:..|.:||:.||:::.:::...||.:..||..||.|::
Human   789 SKLFGVVCAHVGETQRLLILEQLLDSIKHTKGARQQVVQLHVVSSVSSFLKYVAGSKGCLGPEEM 853

  Fly   950 RKSATALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHSH 1014
            ::.|..|::.:|.|.|..:||||.|:..||||||.|..|||.|||.||||||||||||||||||.
Human   854 KRFALTLVMGALESPNPLLRCAAAESWARLAQVVDDGAFTAGLAQVSFDKLKSARDVVTRTGHSL 918

  Fly  1015 ALGCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATLT 1079
            |||.||||:||:.|||||::.:.||..|.|||.||.||.|:|::|:.|.||.||::..:||.||:
Human   919 ALGSLHRYLGGISSSQHLNSCIGILYTLAQDSTSPDVQTWALHSLSLIIDSAGPLYYVHVEPTLS 983

  Fly  1080 LCLKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLVQ 1144
            |.:.|||.||..|.:|||.:||.:||||||:||||||...:::|:|.|.|...|::|.:.|.|||
Human   984 LIIMLLLNVPPTHAEVHQSLGRCLNALITTLGPELQGNSTSISTLRTSCLLGCAVMQDNPDCLVQ 1048

  Fly  1145 AEAIGCLQQLHLFASKSLQLEELVPTLVGMLACNYFILRKASVSCLRQLAHREAKEVCELALTI- 1208
            |:||.||||||:||.:.:.|..||..|...|...|.:||:|.::|||||..|||.||.|.|:.:
Human  1049 AQAISCLQQLHMFAPRHVNLSSLVSCLCVNLCSPYLLLRRAVLACLRQLVQREAAEVSEHAVMLA 1113

  Fly  1209 --NAEQL-PDLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQMLAADNLSSWLSLCKNVL 1270
              :.|:| ||..|.|.||.|.|..|||.|||..:..:|.:||..||..:|.:.||.||.|||:||
Human  1114 KDSREELTPDANIREVGLEGALLILLDKETDERLCHDIKETLNYMLTSMAVEKLSLWLKLCKDVL 1178

  Fly  1271 TVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAEENTSTHPAVQPRWPTRVFA 1335
            ..:.:              .......|..::||.:..||.:......:..:||...|||.|||||
Human  1179 AASAD--------------FTAVTCVDTMQEEEGDKGDDASVLTTRRDEKSHPFTNPRWATRVFA 1229

  Fly  1336 AQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIRMSFMAATSDSDQLRLEGLR 1400
            |:||.|||..||.|:|.|||:..|:|.:...||.|:|:||||:||||:|||||..||||||.||.
Human  1230 AECVCRIINQCENANSAHFDIALAQEMKKRDSRNDFLVLHLADLIRMAFMAATDHSDQLRLSGLE 1294

  Fly  1401 TLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHVTAAACEVCSAWIGSGVARD 1465
            .|..:|.|||.|||||||||::|||:||.|||||||||..:||..|||.||:||||||.|||..|
Human  1295 MLLVVIRRFATVPEPEFPGHVILEQYQANVGAALRPAFTSETPPDVTAKACQVCSAWIASGVVSD 1359

  Fly  1466 IGDLKRVHQLLVSSLDKL-SSKTNSTQLYNESMATLEKLSILKAWAEVYIVAMIGNGKAPASLLN 1529
            :.||:||||||||||.|: :.|...:.|||||.:|:|.|::|||||||||:|:..:
Human  1360 LNDLRRVHQLLVSSLTKIQAGKEALSHLYNESASTMEILAVLKAWAEVYIIAVQRH--------- 1415

  Fly  1530 LQSQQSGFQSLTNLETDSDVPDSRGESLLGLVQPELHNLSTHWLSAMKDHALLLLPAEFQSQLPH 1594
             ::.:...::.|.||..........:.||.||..:|..||..||:|::|.|||.||:||.||||.
Human  1416 -KNHRQPLKTTTCLEDGIRNGSCSSDGLLDLVYADLGTLSRLWLAALQDFALLTLPSEFASQLPA 1479

  Fly  1595 DGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFARHLDTSEAAAESNN----NQITHGSL 1655
            :||||||.:|..::|.||..||..||:|:||||...||. ..|..|.|:..:.    ..:..||.
Human  1480 EGGAFYTAETSENAKLHYYNSWALILHATALWLTSTGFV-VADPDEGASNLSRPVTPTSMCQGSS 1543

  Fly  1656 S-----------ADRFHMIFGICMEALCSMRSSERPRNIVSCLRSLHSIFDSDWARRQLVKDRAL 1709
            |           .||||:|.||.:|.|||:||.....:|.:||.:|.::.|..|.|.::..|:.|
Human  1544 SGATIKSPEDVYTDRFHLILGISVEFLCSLRSDATMESITACLHALQALLDVPWPRSKIGSDQDL 1608

  Fly  1710 TIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLERKR-----DDNANSED-----GKGG 1764
            .|||.:||||.||||:...:||..:|:::|.|.||:|.::.||     ||.|..::     |:|.
Human  1609 GIELLNVLHRVILTRESPSIQLASLEVVRQIICAAQEHVKEKRRSAEVDDGAAEKETLPEFGEGK 1673

  Fly  1765 ERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQGAGGSGLQLDFAYAKMATGSSFFSVL 1829
            :..|    :.||.|.|:|.||:|:|:.|||:|.:||...|:.|          ..||..   .:|
Human  1674 DTGG----LVPGKSLVFATLELCVCILVRQLPELNPKLTGSPG----------VKATKP---QIL 1721

  Fly  1830 GDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMTTSIVKEIANK---SAIDSTILANTCAV 1891
            .::...|||:.|..:.:|..:|:|:|:::||||:||:|..:::|.|.|   ..:.||:.|
Human  1722 LEDGSRLVSAALVILSELPAVCSPEGSISILPTILYLTIGVLRETAVKLPGGQLSSTVAA----- 1781

  Fly  1892 KSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLTKTAGDNEERKVDEVTMLLAITVFIL 1956
              :||.|:.:.....|:.|::...|..||:|||.||:|..... |...:::|||::|.|||||||
Human  1782 --SLQALKGILSSPMARAEKSRTAWTDLLRSALTTILDCWDPV-DETHQELDEVSLLTAITVFIL 1843

  Fly  1957 HTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTRSIFARAELKTATPYIHALAPRIIES 2021
            .|...|...|.||..||:.|:..|:.::..|:::..:...|||.......:.|||::||..|:|.
Human  1844 STSPEVTTIPCLQKRCIDKFKATLEIKDPVVQIKTYQLLHSIFQYPNPAVSYPYIYSLASCIMEK 1908

  Fly  2022 LYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQDIQMLTLLVPVLIGFLAEPSRL 2086
            |.....:.|.:..||::..|.|..:|.|:.::|..:|       .|::..|:|:||.||.:.:.|
Human  1909 LQEIDKRKPENTAELEIFQEGIKVLETLVTVAEEHHR-------AQLVACLLPILISFLLDENSL 1966

  Fly  2087 RTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELRQKLEAAIRSQQQSINIAQKASEAQR 2151
            .:.....|.|||.|||.|::|||:|...||:|:..:|.|:.:|||||:..|:|:.:....|:..:
Human  1967 GSATSIMRNLHDFALQNLMQIGPQYSSVFKSLVASSPALKARLEAAIKGNQESVKVKIPTSKYTK 2031

  Fly  2152 NLLAKPQK-PTIKLKTDF 2168
            :    |.| .:|:|||.|
Human  2032 S----PGKNSSIQLKTSF 2045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	19/27 (70%)
		HEAT repeat	185..213	CDD:293787	11/27 (41%)
		HEAT repeat	225..255	CDD:293787	18/29 (62%)
		HEAT repeat	266..292	CDD:293787	15/25 (60%)
HEATR5A	NP_056288.2	HEAT repeat	97..121	CDD:293787	16/23 (70%)
		HEAT repeat	137..165	CDD:293787	11/27 (41%)
		HEAT repeat	177..207	CDD:293787	18/29 (62%)
		HEAT repeat	218..244	CDD:293787	15/25 (60%)
		HEAT repeat	806..839	CDD:293787	8/32 (25%)
		HEAT 1	852..889		16/36 (44%)
		HEAT repeat	856..886	CDD:293787	13/29 (45%)
		HEAT repeat	895..925	CDD:293787	25/29 (86%)
		HEAT repeat	936..966	CDD:293787	14/29 (48%)
		HEAT 2	1085..1122		17/36 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1652..1674		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143572
Domainoid	1	1.000	1892	1.000	Domainoid score	I4
eggNOG	1	0.900	-	-		E1_KOG1822
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1899	1.000	Inparanoid score	I58
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52955
OrthoDB	1	1.010	-	-		D71064at2759
OrthoFinder	1	1.000	-	-		FOG0001774
OrthoInspector	1	1.000	-	-		otm40580
orthoMCL	1	0.900	-	-		OOG6_102302
Panther	1	1.100	-	-	O	PTHR21663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1338
SonicParanoid	1	1.000	-	-		X1302
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840