DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2747 and tmem131

DIOPT Version :9

Sequence 1:	NP_001262364.1	Gene:	CG2747 / 40950	FlyBaseID:	FBgn0037541	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	XP_031751604.1	Gene:	tmem131 / 100216097	XenbaseID:	XB-GENE-955763	Length:	1885	Species:	Xenopus tropicalis

Alignment Length:	1478	Identity:	261/1478 - (17%)
Similarity:	478/1478 - (32%)	Gaps:	513/1478 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1075 EATLTLCLKLLLTVPHAHVDVHQ-------------------CVGRVVNALITTVGP------EL 1114
            |.|:|| :.:..|..|.|....|                   .||.|.|.|......      ::
Frog   132 EETITL-ISISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQV 195

  Fly  1115 QGGG-----------GAVATMRGSFLCSAALLQSHSDPLVQAEAIGCLQQLHLFASKSLQ----- 1163
            .|.|           ||...:..||.....:...||:||...|.......|||......|
Frog   196 FGIGIPNPYRLRPFIGARVPVNSSFSPLINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRK 260

  Fly  1164 LEELVP-TLVGMLACNYFILRKASVSCLRQLAHREA-KEVCELALTINAEQLPDLVITEYGL--- 1223
            |.|:.| ...|::..::              :.||| .....:.:..||....:.:|....:
Frog   261 LWEIPPYETKGVMRASF--------------SSREADNHTAFIRIKTNASDSAEFIILPVEVEVT 311

  Fly  1224 --PGLLFS--LLDTET----DAEMLRNIH--------------------DTLTSMLQMLAADNLS 1260
              ||:..|  :||..|    ||..:.|:|                    |.:|...:.:   .|.
Frog   312 TAPGIYSSTEMLDFGTLRTQDAPKVLNLHLLNSGMKDVPITSVRSTPQNDAVTVHFKPI---TLK 373

  Fly  1261 SWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAE--------E 1317
            :..|....|.:::.:        |.:..|..:..|:...:.:|:.|:.....|:||        :
Frog   374 ASESKYTKVASISFD--------ASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFD 430

  Fly  1318 NTST--HPAVQPRWPTRVFAAQCVRRII---ASCEAASSVHFDLL--QAKEQQLIRSRGDYLILH 1375
            :.:|  |....|..|        |.|.|   .:...|..:|..||  .||....|::...::::.
Frog   431 HAATLFHIRDSPSDP--------VERAIYLTNTFNFAVLIHDVLLPEDAKPMFKIQNFSSHVLIP 487

  Fly  1376 LAE---LIRMSFMAATS----DSDQLRLEG-------LRTLQEIIDRFANVPEPEFPGHLLLEQF 1426
            ..|   :..:.|..:||    ||:.|.:..       :|.....:|.|...|:.|       |:|
Frog   488 PGESRYIFSLLFTPSTSSVHIDSNILLITNASKFHLPVRAYTGFLDYFILPPKLE-------ERF 545

  Fly  1427 ------QAQVGAALRPAFAPDTPSHVTAAACEVCSAW--IGSGVARDIGDLKRVHQL-LVSSLDK 1482
                  .|...::|..|.....|..:      ...:|  ||..::.|:...::.::. :::||.:
Frog   546 IDFGILSASESSSLLIAIMNSNPIEL------AIKSWLVIGDSLSIDLLTTEKGNRTSIIASLPE 604

  Fly  1483 LSSKTNSTQ---LYNESMATLEKLSILKAWAE-------------------VYIVAMIGN----- 1520
            :.:.|.|.:   :.......:.::||:....|                   |..|..:|:
Frog   605 IENATVSDRTSVILTSGYYAVFRVSIIAKDLEGSYDGGIQITTDYEILTVPVKAVVAVGSLTCSP 669

  Fly  1521 ----------GKAPASLLNLQ---SQQSGFQSLTNLETD--------------------SDV--- 1549
                      ||.....||:.   ||:...|.:.:|..|                    |.:
Frog   670 KRITLPPSFPGKVVHQSLNIMSSFSQKVKIQQIRSLSEDVRFFYKRLRSNKDELEPGKKSKIANI 734

  Fly  1550 ---------------------PDSRGESLLGLVQPEL--------HNLSTHWLSAMKDHALLLLP 1585
                                 .:|:|:.|  .:|.:|        .||...| |.:::::..||.
Frog   735 YFDAALNCGDHCYIGLPFLFKSESKGQHL--AMQEDLWDSDWDYYENLYKKW-SEIRENSDHLLE 796

  Fly  1586 AEFQSQLPHDGGAFYTTDT------INSSKPHYMTSWPPILYASALWLR-----------DEGFA 1633
            |.|:            .||      ::..|...|  ||.:: :|:.::|           :|.|.
Frog   797 AAFE------------VDTDLQKNILSDVKAELM--WPSVV-SSSRYIRFPLTNTNSSTVEEMFL 846

  Fly  1634 R-------HLDTSEAAAESNNNQITHGSLSADRFHMIFGICMEALCSMRSSERP--RNIVSCLRS 1689
            .       ::.....|..|||:.:....:  |||::...:.::    :::.|..  ||.|:.::|
Frog   847 ENPSDAPVYIQILPLALYSNNSFLLERII--DRFNISKSVDID----LKTLEFQVFRNNVNPVQS 905

  Fly  1690 LHSIFDSD-----------WARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRA 1743
            .||..:..           ...:|.||.:...:: ...:...::.|:.|.|    ::::....:.
Frog   906 SHSFVEGSSRHSVLNLVLKSGEKQNVKLKFTPVQ-NQTVSSLLIVRNNLTV----IDVIMVEGQG 965

  Fly  1744 AREDLERKRDDNANSEDGKGGERHGEDDSMQPGSSHVYAVLEV----CLCLFVRQIPTMNPTR-- 1802
            |:|:|:            ..|:..|      ||||..:.:.|.    |......:.|.....|
Frog   966 AKENLK------------VAGKPPG------PGSSLRFKITEAFLKDCTDKIKHREPNFTMKRTF 1012

  Fly  1803 --QGAGGSGLQLDFAYAKMATGSSFFSVLGDENGLLVSSGLQCVEQLMDLCTPKGA--LAILPTV 1863
              :..|    |||.....|..  |.:|..|  .|..:   |.|.|..:.   |..:  :.||.|.
Frog  1013 KLENTG----QLDVTVKSMEI--SGYSCEG--YGFKI---LNCNEFALG---PNASREVTILFTP 1063

  Fly  1864 LYMTTSIVKE--IANKSAIDSTILAN---------TCA------------------VKSALQCLR 1899
            .:.::.:::|  |..:...:...:.|         |||                  :.|.|..|
Frog  1064 DFTSSRVIRELRIVTEGGSEFVFILNASLPYHMLATCAEALPRPNWELALYVIISGIMSLLFLL- 1127

  Fly  1900 SVCVHKWAKVEETTEEWQQLL--QSALATIV-----DLTKTAGDNEERKVDEVTMLLAITVFILH 1957
             |.|..:.:.:...|.:::.|  :||..:||     ||.:..|.:.|...:.|..      ...|
Frog  1128 -VIVTAYLEAQGIWEPFKRRLSFESAHPSIVFGRPFDLRRIVGISSESSFNSVGS------DSNH 1185

  Fly  1958 TPASVVATPSL--------QYPC-----INHFRQCLQSE--------NLSVKLRCIETTRSIFAR 2001
            :....:.|.|.        |.||     :.:.|....:|        |::.||    ::::..|:
Frog  1186 SSNRGLYTGSTSTRTGAGNQKPCNPVSNLQNSRSAPDAELSRPKNSSNIASKL----SSQAAVAQ 1246

  Fly  2002 AELKTATPYI--------HALAPRIIESLYAE------------SSKVPTSELELQVTLESIVTV 2046
            ...|..:|..        .||..|...:..::            |..||..:.|.|..:...||
Frog  1247 PSSKAPSPQTDSNTVVQNQALTRRTRGTRLSQNQVSQEQLPSTPSPAVPPPQAEQQAEISQPVT- 1310

  Fly  2047 EQLIDLSEPQ-----NRNMNLLQDIQMLTLLVPVLIG------------FLAEPSR--LRTLPKY 2092
               .:.|.|:     :.|.....|...:|.|:..:..            |..:|..  |:...|.
Frog  1311 ---SNTSHPEYFRASSSNARHSSDDSDITNLIEAMDKDFDQSEITHSDVFTEQPPSPVLKNKGKT 1372

  Fly  2093 QRQLHDQALQWLLKIGPKYPQEFKALMGQTPE--------------------------------- 2124
            :..:|....|      .|..::.:.:.|:..|
Frog  1373 RSVMHKSKFQ------KKQEEKDRRIKGKQLEDELKDSLADDDSSSTTTETSNPDTEPPVKEDGE 1431

  Fly  2125 -LRQKLEAAIRSQQQSINIAQKASEAQRNLLAKPQKPTIKLKTDFSNF 2171
             |:.|....::|:::.:.:..|..:|..|  .|...|.:|....|.:|
Frog  1432 KLKGKQTIPVKSEREILKVKPKGKKAANN--KKESIPEVKQSHVFHHF 1477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787
		HEAT repeat	185..213	CDD:293787
		HEAT repeat	225..255	CDD:293787
		HEAT repeat	266..292	CDD:293787
tmem131	XP_031751604.1	ASH	103..185	CDD:417311	13/53 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165163124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930