Protein Alignment CG2747 and heatr5a

DIOPT Version :10

• Sequence 1: NP_001262364.1
• Gene: CG2747 / 40950
• FlyBaseID: FBgn0037541
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: XP_012823240.2
• Gene: heatr5a / 100036639
• XenbaseID: XB-GENE-5868140
• Length: 2030
• Species: Xenopus tropicalis
• Alignment Length: 2184
• Identity: 912/2184 - (41%)
• Similarity: 1317/2184 - (60%)
• Gaps: 211/2184 - (9%)

  Fly    40 ETEEEAISEMELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQL 104
            |.||..:..:::|           :|.|.:|.:..|||||:|.:.||::::||||.:||:||:||
 Frog     2 ELEERGLQLLDVA-----------ELEEPQRGLRVLEWLRHLRRVLPVITRAEIKENQKQLVEQL 55

  Fly   105 SERIQGAPGPPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGS 169
            ...:.|.||||.|:|:|..:|.::|.||||.:::|::.|||::::|||||||||:||||:..||:
 Frog    56 LLVMMGFPGPPARRLLAYNMAFVYSSGDTFSVYETIDRCNDVIRSKDDSPSYLPSKLAAVACLGA 120

  Fly   170 MYEKLGRMMGRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCL 234
            :|:||||::|.|:.|||..|::.||:||||.|.|||.:||::..|:|:|....|:||||||:.||
 Frog   121 LYQKLGRLLGSTFSDTVSNLLKVLRSAESQGRSEIMLSLERILKGLGSAAIPCHRDIYKAARSCL 185

  Fly   235 LDRVMAVRVAAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQ 299
            .||.|:||.:||:|:|.:...|.|::.::||||.::||:||:||:||||.|||:|||.:||...|
 Frog   186 TDRSMSVRCSAAQCLLALQKEASFMWGSDLESLASICFKAFEGSSYEVRLAVARLLGKVLARAMQ 250

  Fly   300 LAEAATSKKKQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNRE 364
               .|||.::..             |.:||.|.||:|.:|||||.:.||:|.|:::.|:|...|.
 Frog   251 ---GATSPRQNA-------------RKLSLQEVLGLLSTGFLRGNSGFLRGGGDMLGGTSVTTRH 299

  Fly   365 VRVGVTHAYVVFVQFMGSVWLERQLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGK 429
            ||:|.|.||:||::.:|..||.|.:...|:|.|:|::||||..:..||..||.|||:|||:|:|:
 Frog   300 VRLGATQAYIVFIRTLGGHWLARNVPVLLSHSLELISNPKAIQNPTDAACSRCCISYILRATVGE 364

  Fly   430 MLGEKAQSAACKELVHLVAKQMNSIDFNPENAKDSNQETLF-------SQHLLVCALQELSSLLI 487
            :||||||..|.:|:..::.|.|.::|   ....|||.||.|       |||:||||||||..|.:
 Frog   365 LLGEKAQLEAAREICEVIRKLMKTVD---AVLSDSNLETRFCTTDISASQHVLVCALQELGDLFL 426

  Fly   488 GLGTTAQNLLGDQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQM 552
            ||||....||.|.|...:|...:|.:||..:||||||||||...|::|....|::||.||.:..:
 Frog   427 GLGTILAPLLKDSSAGVLDTVLSVSLHPSLSARLAAAWCLRSVIVSLPSLAAPVLDRCVERLTAL 491

  Fly   553 RSSPEAMAGYSCALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLI 617
            :|||||::|||...|.:|||:|..|||:||.|||||.:.|::||.:||||||.||.|||||||||
 Frog   492 KSSPEAVSGYSLTAAVLLGSIRLCPLGVPHGKGKVVMSLAKDLLCTASQNSRFSLQRTQAGWLLI 556

  Fly   618 GAIMTLGSPVVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLN 682
            .::||||..||:..|..:|||||:.||.:.|:|::|:.||||||||||||||||||..|.||:.:
 Frog   557 ASLMTLGPAVVQSQLGCLLLLWRSVFPVTPKDLDTERRRGDAFTWQVTLEGRAGALGAMRSFVSH 621

  Fly   683 CPDLLNEDITRRLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASY 747
            |.:|::|::.:|||.|:..|:|:|..|.|:.|.||..|||.:.:.|.||::.|.|||....|.|:
 Frog   622 CGELMSEEVLQRLLPPLPCAIALLTLLPSLQKLYGNSLKACSVLYRQRLYQLLVLLPPKTYEESF 686

  Fly   748 THLLRMLVSEFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQ 812
            ..:::.||::.|..|.:......||.::||.||.::||...||.:.|..|           |.|.
 Frog   687 CAVMKELVADLTSPDYSPGGAAFLLSSVCHPDDLVLLGPSFQECDQRATE-----------EELL 740

  Fly   813 PNSAAGSGALEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLG 877
            .:|....|:||:|...:|                               :..|:.:..|.|||..
 Frog   741 LSSGIPGGSLEYDLHAIY-------------------------------ELPSEGESVPKPLPSA 774

  Fly   878 VAVIDMAVTLYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKT 942
            ..||..|..|:||:...:....|.|:|:...|.|:|.|.|||::||:...::|...||:|..|::
 Frog   775 FTVIQAASLLFGTLLAHMPESQRPQILQQLVESIKQTKGSRQQSVQLCAMSSLCNFLKHLASSRS 839

  Fly   943 SLGQEDVRKSATALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVV 1007
            :||.|::||...:||.|.|...:..:|||..|::.||.|||.|..|||.|.|.||||||:|||||
 Frog   840 NLGPEEMRKPCLSLIQAVLEGNSLWLRCAGVESVARLVQVVDDPTFTAGLIQASFDKLKTARDVV 904

  Fly  1008 TRTGHSHALGCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRG 1072
            .||.||..||.||||:||:.|||||::.|.:|.:|.||:.||.||.|:|::|:.|.|..||:|..
 Frog   905 ARTSHSLVLGTLHRYLGGINSSQHLASCVGVLHSLSQDTTSPEVQTWALHSLSVITDLSGPLFNV 969

  Fly  1073 YVEATLTLCLKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQS 1137
            ::||||:|.|..|:|...:|.:||:.:||.::||:|.:||||||.|..:::.|.|.|.:.:::|.
 Frog   970 HIEATLSLLLTALITTSPSHPEVHRSLGRCLSALVTALGPELQGNGAVLSSQRTSCLLACSVMQE 1034

  Fly  1138 HSDPLVQAEAIGCLQQLHLFASKSLQLEELVPTLVGMLACNYFI---------LRKASVSCLRQL 1193
            :.|.||||:.|.||||||::|.|.:.|..|||||..:|..|..:         ||:|.::|||||
 Frog  1035 NPDCLVQAQGISCLQQLHMYAPKHVNLSSLVPTLCEVLLDNTMLVHLYSPHLPLRRAVLACLRQL 1099

  Fly  1194 AHREAKEVCELALTINAEQLPDLV----ITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQML 1254
            |.|||.||.|.|:|:..|...||.    :.|.||.|:|.||||.|:|.::||::.:||..|....
 Frog  1100 AQREAAEVSEHAMTVAKEGHEDLKMEMNMRELGLEGVLLSLLDRESDQQLLRDVKETLLHMQNCT 1164

  Fly  1255 AADNLSSWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADD--VTEYRAEE 1317
            ....||.||.:.|::|:.:.      |.||       .|..:.::|||.|....|  :|..:||
 Frog  1165 GLSRLSFWLRMLKDILSASA------DFAA-------VASVDTNQEDEGEVACSDSVLTSSKAE- 1215

  Fly  1318 NTSTHPAVQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIRM 1382
              |...:|.|.|.||:||.:||.::|..||.....|||:.||:|.:......|:|:|||.:||||
 Frog  1216 --SLGSSVTPHWKTRIFAMECVCQLITQCELDGGAHFDMAQAQEMKHKEPERDFLVLHLQDLIRM 1278

  Fly  1383 SFMAATSDSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHVT 1447
            ||||||..|:||||.||:.|..:|.|||.||||||||||:||||||.|.||:||||..|||..||
 Frog  1279 SFMAATDHSEQLRLVGLQALLLVIHRFAAVPEPEFPGHLILEQFQANVLAAVRPAFNTDTPPDVT 1343

  Fly  1448 AAACEVCSAWIGSGVARDIGDLKRVHQLLVSSLDKLSSKTNSTQLYNESMATLEKLSILKAWAEV 1512
            |.||||||||:.|||.:::.||:||.|||::||.::.....:..:|:||...:|.|::|||||||
 Frog  1344 ARACEVCSAWLASGVVKELADLQRVQQLLLTSLRRVQVAKETASVYSESTTAMESLAVLKAWAEV 1408

  Fly  1513 YIVAMIGNGKAPASLLNLQSQQSGFQSLTNLETDSDVPDSRGESLLGLVQPELHNLSTHWLSAMK 1577
            ||.||             :.|          .|.|.:.:::.|.||.|||.||..||..||:|::
 Frog  1409 YIAAM-------------EKQ----------VTQSKMAEAQNEVLLSLVQAELLTLSGLWLAALQ 1450

  Fly  1578 DHALLLLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFA--------R 1634
            |||||.|||...||||..||.|||.:|.::::|||:.||.|||:||:|||...||.        .
 Frog  1451 DHALLTLPAACASQLPSQGGGFYTAETSDAARPHYLLSWAPILHASSLWLSSSGFVLPDQDEGNG 1515

  Fly  1635 HLD---TSEAAAESNNNQITHGS---LSADRFHMIFGICMEALCSMRSSERPRNIVSCLRSLHSI 1693
            ||.   |..:..:...:|:...|   |:.:|||:|.||.:|.||..........|.||||:|.::
 Frog  1516 HLSRPVTPTSMGQERGSQLPADSPEDLNLERFHLILGISVEFLCCPPVDAPMERITSCLRALKAL 1580

  Fly  1694 FDSDWARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDL-ERKR----D 1753
            ....|.:..:..|:.|.|||..||||.:|.|:...||||.:|:.:..:.||::.: ||:|    |
 Frog  1581 LSGMWPKAHIGTDQDLAIELISVLHRLLLMRESSEVQLLVLEVGRLIVNAAQDHVRERRRSAEVD 1645

  Fly  1754 DNANSED-----GKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQGAGGSGLQLD 1813
            |.|..::     |:|.:..|    :.||.|.|.|.||:|||:.:||:|.::|...|.
 Frog  1646 DGAEEKETLPVFGEGHDTGG----LVPGHSLVVAALELCLCILIRQLPQLSPHLSGG-------- 1698

  Fly  1814 FAYAKMATGSSFFSVLG------DENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMTTSIVK 1872
                         ||:|      .|..|||:|.|..:.:|..||:|:|::::|||:||:...:::
 Frog  1699 -------------SVVGKTEPLFSEARLLVASSLGILAELPSLCSPEGSVSVLPTLLYLVVGVLQ 1750

  Fly  1873 EIANKSAIDSTILANTCAVKSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLTKTAGDN 1937
            :...|.. |..:   |..|.:|||.|:.:.....::||:....|.:|:|||::|:::     ..:
 Frog  1751 DTTVKFP-DGHL---TLPVTAALQALKVIVSSPMSQVEKCRASWTRLMQSAVSTLLN-----SWH 1806

  Fly  1938 EERKV--DEVTMLLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTRSIFA 2000
            .||::  |.|::|.|:|:|:|.....|::.|.||..|:..|:..:.|:|.:.:|:|.....|||.
 Frog  1807 LERQLVPDSVSLLTALTIFLLSANPEVMSDPGLQNACVQRFQNSIDSKNPTEQLKCYRLLLSIFK 1871

  Fly  2001 RAELKTATPYIHALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQD 2065
            ....:...||:.:|||||:..|....|:.|.|..||.|..|.:..::.|:...|.|||.
 Frog  1872 HPVPEVVAPYVCSLAPRIMRHLSQAESRKPQSMEELLVLQEGVNLLKTLVSAVEEQNRP------ 1930

  Fly  2066 IQMLTLLVPVLIGFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELRQKLE 2130
             .|:.:|:.:||.||.:.:.|.:.|.|.|.|||..|..|...|..||.:|:.|||.:|.||.:||
 Frog  1931 -SMVCMLLHLLISFLLDENALGSAPHYSRALHDFGLHSLTSFGASYPTQFRKLMGSSPALRSRLE 1994

  Fly  2131 AAIRSQQQSINIAQKASEAQRNLLAKPQ-KPTIKLKTDF 2168
            ||:|..|:|:    |.....|..:.... .|:|:|||:|
 Frog  1995 AALRGNQESL----KPKAPSRGTMGGSHGSPSIQLKTNF 2029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	17/27 (63%)
		HEAT repeat	185..213	CDD:293787	15/27 (56%)
		HEAT repeat	225..255	CDD:293787	17/29 (59%)
		HEAT repeat	266..292	CDD:293787	17/25 (68%)
		Laa1_Sip1_HTR5	1371..1581	CDD:466361	109/209 (52%)
heatr5a	XP_012823240.2	HEAT repeat	96..120	CDD:293787	15/23 (65%)
		HEAT repeat	136..164	CDD:293787	15/27 (56%)
		HEAT repeat	176..206	CDD:293787	17/29 (59%)
		HEAT repeat	217..243	CDD:293787	17/25 (68%)
		Laa1_Sip1_HTR5	1267..1454	CDD:466361	109/209 (52%)