DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pbp95 and DMTF1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001135799.1	Gene:	DMTF1 / 9988	HGNCID:	14603	Length:	760	Species:	Homo sapiens

Alignment Length:	685	Identity:	121/685 - (17%)
Similarity:	216/685 - (31%)	Gaps:	227/685 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KGNLFFRDIDGRSCPNNEDYEARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHRAHST 163
            :|||...      ||.||..|......:.|.    |.|...:..|.:::               .
Human    26 EGNLILH------CPQNEADEIDSEDSIEPP----HKRLCLSSEDDQSI---------------D 65

  Fly   164 NALPSGSLKRKPIERHLSTLVSLLATADSSFSIDWNQISTLDLEYRHSPYSCEAMWRVYLTPDLR 228
            ::.|..|:...|:..:           |.||.:    ..|...|......:...:.::.:..:.:
Human    66 DSTPCISVVALPLSEN-----------DQSFEV----TMTATTEVADDEVTEGTVTQIQILQNEQ 115

  Fly   229 RDDWSPEEDETLLAVATANRMQNWELIAASLDRRSDYQCFVRFHTALRFLLEPKNS-----HR-- 286
            .|:.||..:|.:.||:     |.|                  |.|.     |.|:|     |:
Human   116 LDEISPLGNEEVSAVS-----QAW------------------FTTK-----EDKDSLTNKGHKWK 152

  Fly   287 ---WSEEDNDKLRAIVDRN-TANSVINWKKVV-EYFPDKSKSTLIGRYYYVLHPSISHEPFTTKE 346
               ||:|:.|.|...::|. .|..:.:..::: |...|:.|.     :|..:...::...|....
Human   153 QGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKD-----FYRTIAWGLNRPLFAVYR 212

  Fly   347 DMMLFAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHN---------------------VLAQRNK 390
            .::.......:.||:  .|..:   ..|.:||.::.|                     ::.....
Human   213 RVLRMYDDRNHVGKY--TPEEI---EKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCN 272

  Fly   391 TDSWSVQDDTRLMSFVTQYGASQ----------WLNCATFLGNHTRTSCRTRFLVIKKFLEQNPN 445
            |..|:.:::.||...|.:..:::          |...|..:|..:...||:::|   .:|....:
Human   273 TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWL---NYLNWKQS 334

  Fly   446 AKVEDLPRRRSKKVSLV-----------NSDNWAQRLQEWQEDPESLVNDNPPKGTRVRGP---K 496
            ...|   ..:..:::|:           |..||....:.|               :.||.|   :
Human   335 GGTE---WTKEDEINLILRIAELDVADENDINWDLLAEGW---------------SSVRSPQWLR 381

  Fly   497 SKKARIERQAESFSRLSKVDIEFCNFFKFSYNLTLSTPKTFPVPKDVYNLAYVIRALAYKPPIRP 561
            ||...|:||..:...:|                       |||      |...::.|.......|
Human   382 SKWWTIKRQIANHKDVS-----------------------FPV------LIKGLKQLHENQKNNP 417

  Fly   562 SLLQN---IFMPNDVLKCYNSMIRN-------LPDEEGDMKSPLLPPNWSTMMGFRALCILSGDC 616
            :||:|   ..:||...   ||.:::       |.|......||:.    :..:..:...:.|.|.
Human   418 TLLENKSGSGVPNSNT---NSSVQHVQIRVARLEDNTAISSSPMA----ALQIPVQITHVSSADS 475

  Fly   617 RKDTETRSFEYN-------ESLPPIQLFRKRLQALFYRTTLLSRLESQLFTDLPSALVSLPRPKH 674
            ....::.:...|       |.||...|.......    |.||....||   .||..|.:.|.
Human   476 PATVDSETITLNSGTLQTFEILPSFHLQPTGTPG----TYLLQTSSSQ---GLPLTLTASPT--- 530

  Fly   675 DYAKMGTHVELIDPEPAPQNDLKSEPLSENEVINT 709
                    |.|....||....:....||...::||
Human   531 --------VTLTAAAPASPEQIIVHALSPEHLLNT 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	7/45 (16%)
		SANT	229..276	CDD:197842	10/46 (22%)
		Myb_DNA-binding	229..275	CDD:278669	10/45 (22%)
		Myb_DNA-bind_6	287..350	CDD:290632	12/64 (19%)
		SANT	392..438	CDD:197842	10/55 (18%)
		Myb_DNA-binding	393..437	CDD:278669	10/53 (19%)
DMTF1	NP_001135799.1	Interaction with CCND2. /evidence=ECO:0000250	1..237		50/288 (17%)
		Required for DNA-binding. /evidence=ECO:0000250	87..458		78/465 (17%)
		Required for transcriptional activation. /evidence=ECO:0000250	87..170		21/114 (18%)
		SANT	<89..438	CDD:333364	75/439 (17%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000250	176..760		80/467 (17%)
		Myb_DNA-bind_6	228..284	CDD:316443	7/58 (12%)
		Myb_DNA-binding	274..329	CDD:306708	10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..435		6/23 (26%)
		Required for transcriptional activation. /evidence=ECO:0000250	459..760		24/121 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930