DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pbp95 and CDC5L

DIOPT Version :9

Sequence 1:NP_649760.1 Gene:Pbp95 / 40949 FlyBaseID:FBgn0037540 Length:721 Species:Drosophila melanogaster
Sequence 2:NP_001244.1 Gene:CDC5L / 988 HGNCID:1743 Length:802 Species:Homo sapiens


Alignment Length:621 Identity:129/621 - (20%)
Similarity:221/621 - (35%) Gaps:168/621 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 WNQISTLDLEYRHSPYSCEAMWRVYLTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASLDRR 262
            |::|::  |.:|.|...|:|.|..:|.|.:::.:||.||:|.||.:|.....| |..||..:.|.
Human    31 WSRIAS--LLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQ-WRTIAPIIGRT 92

  Fly   263 SDYQCFVRFHTALRFLLEPKNSHRWSEE------------------------------DNDKLRA 297
            : .||...:    .|||: |.:.|.:||                              |.|:|..
Human    93 A-AQCLEHY----EFLLD-KAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEM 151

  Fly   298 IVD-----RNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHE---------------PF 342
            :.:     .||.......|...:...:..:...:.:...:....|..:               ||
Human   152 LSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPF 216

  Fly   343 TTKEDMMLFAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDSWSV--QDDTRLMSF 405
            ..|..:..:...||.........|.|.......:||:...   .:..|.|...:  :.::.|.|.
Human   217 EKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKE---GRDRKKDKQHLKRKKESDLPSA 278

  Fly   406 VTQ-YGASQWLNCATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVED--------------LPRRR 455
            :.| .|.|::            |..|::.::        |..::.|              :.|:.
Human   279 ILQTSGVSEF------------TKKRSKLVL--------PAPQISDAELQEVVKVGQASEIARQT 323

  Fly   456 SKKVSLVNSDNWAQRLQEWQEDPESLVNDNPPKGTRVRGPKSKKARIERQAESFSRLSKVDIEF- 519
            :::..:.||.: :..|.|:.....|:....|      |.|.|:. ||.::|::...|:.||... 
Human   324 AEESGITNSAS-STLLSEYNVTNNSVALRTP------RTPASQD-RILQEAQNLMALTNVDTPLK 380

  Fly   520 ------CNFFKFS-----------YNLTLSTPKTFP-------VPKDVYNLAYVIRALAYKPPIR 560
                  .:...||           .|..||||...|       .|:.......||.:...:.|:|
Human   381 GGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLR 445

  Fly   561 PSLLQNIFMPNDVLKCYN--SMIRNLPDEEGD-MKSPLL----PPNWSTMMGFRALCILSGDCRK 618
            ..|..|   |.|.:..|:  |.::.:..|..: ::..||    |.|     .|.  .:|..:..|
Human   446 DKLNIN---PEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKN-----DFE--IVLPENAEK 500

  Fly   619 DTETRSFE--YNESLPPIQLFRKRLQAL--FYRTTLLSRLESQLFTDLPSALVSLPRPKHDYAKM 679
            :.|.|..:  |.|....:.   .|.||:  ..|...:.|:...:..|       ||||..   ..
Human   501 ELEEREIDDTYIEDAADVD---ARKQAIRDAERVKEMKRMHKAVQKD-------LPRPSE---VN 552

  Fly   680 GTHVELIDPEPAPQNDL-KSEPLSENEVINTVKQEL 714
            .|.:..::.|| |..|| |||.|.:.|:|..:..:|
Human   553 ETILRPLNVEP-PLTDLQKSEELIKKEMITMLHYDL 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pbp95NP_649760.1 DUF883 4..>74 CDD:295076
SANT <194..240 CDD:304392 15/41 (37%)
SANT 229..276 CDD:197842 15/46 (33%)
Myb_DNA-binding 229..275 CDD:278669 15/45 (33%)
Myb_DNA-bind_6 287..350 CDD:290632 12/112 (11%)
SANT 392..438 CDD:197842 8/48 (17%)
Myb_DNA-binding 393..437 CDD:278669 7/46 (15%)
CDC5LNP_001244.1 REB1 6..>303 CDD:227476 58/303 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..143 3/34 (9%)
Nuclear localization signal. /evidence=ECO:0000255 165..271 13/108 (12%)
Required for interaction with CTNNBL1. /evidence=ECO:0000269|PubMed:21385873 200..206 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..278 5/33 (15%)
Interaction with PPP1R8. /evidence=ECO:0000269|PubMed:10827081 260..606 81/380 (21%)
Myb_Cef 404..655 CDD:403131 52/208 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..443 8/34 (24%)
Interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:O08837 501..659 27/101 (27%)
Smc <626..802 CDD:224117
Interaction with PLRG1. /evidence=ECO:0000269|PubMed:11544257 706..800
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5147
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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