DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp95 and NSI1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_010309.3	Gene:	NSI1 / 851590	SGDID:	S000002433	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	434	Identity:	87/434 - (20%)
Similarity:	148/434 - (34%)	Gaps:	109/434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 NSLNLSGAILRKGTFRFKGNLFFRDIDGRSCPNNEDYEARCHTEMFPTDFDMHSRHVWTLLDKKN 146
            |..|.|..::|          .:.|::|  .||:..|..|  |...| :.|:.|..:....::.|
Yeast   197 NFNNNSSTLVR----------IYTDLEG--IPNDGSYIKR--TPKIP-EKDVKSDDLILAPEENN 246

  Fly   147 VIMGIKQQLLEHRAHSTNALPSGSLKRKPIERHLSTLVSLLATADSSFSID-----WNQISTLDL 206
                          ..|..|.|..:|...|:..::..:....|.....::|     :.:|..||.
Yeast   247 --------------GDTALLRSDIVKASVIDGAITKSIGKKFTPSEENALDQFIEEYMKIRGLDR 297

  Fly   207 EYRHSPYSCEAMWRV-----------------YLTPDL-------------RRDDWSPEEDETLL 241
            .     ..||.:|..                 |.|...             :|..|:||||:. |
Yeast   298 R-----QMCERIWSTDGVIRDGFWANISKVLPYRTRSSIYKHIRRKYHIFEQRGKWTPEEDQE-L 356

  Fly   242 AVATANRMQNWELIAASLDRRSDYQCFVRFHTALRFLLEPKNSHRWSEEDNDKLRAIVDRNTANS 306
            |.....:..:|..:...|.|..: .|..|:...:: ....:.|.|||:|:.:.|..:|     |.
Yeast   357 ARLCLEKEGHWTEVGKLLGRMPE-DCRDRWRNYMK-CGSKRGSKRWSKEEEELLTTVV-----NE 414

  Fly   307 VINWKKVVEYFPDKSKSTLIGRY--YYVLHPS---ISHEPFTTKEDMMLFAAVEEYNGKFHCFPR 366
            :|......:.......:....||  .|...|.   ||..|  |.:||:.:..|.|
Yeast   415 MIEEAHQYQRMKALEAANKNDRYNQMYSRGPKGKRISDNP--TFKDMINWTVVSE---------- 467

  Fly   367 SLFPNRSLTQLRTRYHNVLAQRNKTDSWSVQDDTR--LMSFV-----TQYGASQWLNCATFLGNH 424
            .:...||..|.|.:::.::.........|:....|  |:..:     |.|....|.:.||:...:
Yeast   468 RMSGTRSRIQCRYKWNKLVTDEAARSMLSIPVSERKWLLERLKQLPKTSYSNIDWNSIATYKPGY 532

  Fly   425 TRTSCRTRFLVIKKFLEQNPNAKVEDLPRRRSKKV--SLVNSDN 466
            .||....| |..::..|     |:.|...|.:.::  ||:...|
Yeast   533 PRTGLELR-LCYEQMRE-----KIHDFKGRSTAEIIDSLLEQIN 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	15/80 (19%)
		SANT	229..276	CDD:197842	13/46 (28%)
		Myb_DNA-binding	229..275	CDD:278669	13/45 (29%)
		Myb_DNA-bind_6	287..350	CDD:290632	17/67 (25%)
		SANT	392..438	CDD:197842	12/52 (23%)
		Myb_DNA-binding	393..437	CDD:278669	12/50 (24%)
NSI1	NP_010309.3	REB1	53..567	CDD:227476	86/429 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930