Protein Alignment Pbp95 and TTF1

DIOPT Version :10

• Sequence 1: NP_649760.1
• Gene: Pbp95 / 40949
• FlyBaseID: FBgn0037540
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_047279794.1
• Gene: TTF1 / 7270
• HGNCID: 12397
• Length: 938
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 110/607 - (18%)
• Similarity: 194/607 - (31%)
• Gaps: 201/607 - (33%)

  Fly   114 NNEDYEARCHTEMFPTDFDMHSR---HVWTLLDKKNVIMGIKQQLLEHRAHSTNALPSGSLKRKP 175
            |::::||....|...:.:...|:   .|.| ::....:.|.|:              |.|.|:|.
Human   373 NHQEFEAVAMPESLESAYPEGSQVGSEVGT-VEGSTALKGFKE--------------SNSTKKKS 422

  Fly   176 IERHLSTLVSLLATADSSFSI-DWNQISTL-DLEYRHSPYSCEAMWRVYLTPDLRRDDWSPEEDE 238
            .:|.|:::.....:.| .||: ..|..||| |                           |.|.|.
Human   423 KKRKLTSVKRARVSGD-DFSVPSKNSESTLFD---------------------------SVEGDG 459

  Fly   239 TLLAVATANRMQNWELIAASLDRRSDYQCFVRFHTALRFLLEPKN-SHRWSEEDNDKLRAI---- 298
            .::.....:|.:          ::....|....|......|||.| .|.....::.::|.:
Human   460 AMMEEGVKSRPR----------QKKTQACLASKHVQEAPRLEPANEEHNVETAEDSEIRYLSADS 514

  Fly   299 --VDRNTANSVINWKKVVEYFP---DKSKSTLIGRY---------YYVLHPSISHEPFTTKEDMM 349
              .|.:.|:.....|::.|:.|   |::.||:...|         :.....:|....|:.||:..
Human   515 GDADDSDADLGSAVKQLQEFIPNIKDRATSTIKRMYRDDLERFKEFKAQGVAIKFGKFSVKENKQ 579

  Fly   350 LFAAVEEY---NGKFHCFPRSLFPNR------SLTQLRTRY-HNVLAQRNKTDSWS-VQDDTRLM 403
            |...||::   .| .....:.|:.:|      .:|.|:.|| ..:...||....|. :....:.|
Human   580 LEKNVEDFLALTG-IESADKLLYTDRYPEEKSVITNLKRRYSFRLHIGRNIARPWKLIYYRAKKM 643

  Fly   404 SFVTQY------GASQWLNC-ATFLGNHTRT----------SCRTRF------------------ 433
            ..|..|      |.::.|.. .:.|||..:|          |...:|
Human   644 FDVNNYKGRYSEGDTEKLKMYHSLLGNDWKTIGEMVARSSLSVALKFSQISSQRNRGAWSKSETR 708

  Fly   434 --------LVIKKF-----------LEQNPNAKVEDLPRRRSKKVSLVNSD------NWAQRLQE 473
                    :::||.           |::||.:.:..:..:..|.:|.|..:      ||.|...:
Human   709 KLIKAVEEVILKKMSPQELKEVDSKLQENPESCLSIVREKLYKGISWVEVEAKVQTRNWMQCKSK 773

  Fly   474 WQEDPESLVNDNPPKGTRV----RGPKSKKARIERQAE--------------------------- 507
            |.|    ::......|.|:    ...::|.:.|||..|
Human   774 WTE----ILTKRMTNGRRIYYGMNALRAKVSLIERLYEINVEDTNEIDWEDLASAIGDVPPSYVQ 834

  Fly   508 -SFSRLSKVDIEFCNFFKFSYNLTLSTPKTFPVPKDVYNLAYVIRALAYKPPIRPSLL---QNIF 568
             .||||..|.:.|.....|...:......|.|:.|:........:....:.|..|..:   ::||
Human   835 TKFSRLKAVYVPFWQKKTFPEIIDYLYETTLPLLKEKLEKMMEKKGTKIQTPAAPKQVFPFRDIF 899

  Fly   569 MPNDVLKCYNSMIRNLPDEEGD 590
            ...|             |.||:
Human   900 YYED-------------DSEGE 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	SANT	<194..240	CDD:473887	10/47 (21%)
		SANT	229..276	CDD:197842	6/46 (13%)
		Myb_DNA-bind_6	287..350	CDD:372817	14/80 (18%)
		SANT	392..438	CDD:197842	12/89 (13%)
TTF1	XP_047279794.1	Myb_DNA-bind_6	654..710	CDD:372817	8/55 (15%)