DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pbp95 and SNAPC4

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001381130.1	Gene:	SNAPC4 / 6621	HGNCID:	11137	Length:	1469	Species:	Homo sapiens

Alignment Length:	657	Identity:	138/657 - (21%)
Similarity:	238/657 - (36%)	Gaps:	177/657 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DADDLRINQQQLMDEIS----ALLQNTAKPSAANALQLNQELQRRLMQVRTKILAMLQVVRARFS 63
            |..|..|::::...|.|    .....|........||||...|    :|..:.||...::.|:..
Human    52 DPADPPISEEERWGEASNDEDDPKDKTLPEDPETCLQLNMVYQ----EVIQEKLAEANLLLAQNR 112

  Fly    64 RNEDILVRRLRPRSHFGPNSLNLSGAILRKGT----------FRFKGNL---FFRD-IDGRSCPN 114
            ..::.|:|             :|:|:   |||          ..:.|:.   :|:| :.|...|.
Human   113 EQQEELMR-------------DLAGS---KGTKVKDGKSLPPSTYMGHFMKPYFKDKVTGVGPPA 161

  Fly   115 NEDYE------ARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHR------AHSTNALP 167
            |||..      .:...|:..|.:....:    .|.:|:|:....|:||:.:      .|...:..
Human   162 NEDTREKAAQGIKAFEELLVTKWKNWEK----ALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKV 222

  Fly   168 SGSLKRKPIERH----------LSTLVSLLATADSSFSIDWNQISTLDLEYRHSPYSCEAMWRVY 222
            |..|:|:.:|:.          ::.|.......:...|.||.:||.::.|...|.......|:..
Human   223 SSELERQALEKQGREAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNS 287

  Fly   223 LTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASL-DRRSDYQCFVRFHTALRFLLEPKNSHR 286
            ..|.:.:.:||.||:|.|.|:|.|:....|:.||..| ..||.:||..:|....:.|    ....
Human   288 EHPSINKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKAL----KRKE 348

  Fly   287 WSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMMLF 351
            |:||::..|..:|......|.|.::::|.|...:....||.|:...|.|.:....:..:||..|.
Human   349 WTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLL 413

  Fly   352 AAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDSWSVQDDTRLMSFVTQYGASQWLN 416
            .||.:|..:.....|...|.||..|.|.||...|....|...|:::::.:|:..:.:||...|..
Human   414 QAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAK 478

  Fly   417 CATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRR-------------------------S 456
            .|:.|.:.:.:.|.:::.::.        .|.:.|.|||                         |
Human   479 IASELPHRSGSQCLSKWKIMM--------GKKQGLRRRRRRARHSVRWSSTSSSGSSSGSSGGSS 535

  Fly   457 KKVSLVNSDNWAQRLQEWQED-----PESLVND------------------------------NP 486
            ...|..:.::..::.|..:.|     |:.:|.|                              :|
Human   536 SSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSP 600

  Fly   487 PKGT----------------------------RVRGPKSKKAR-----------IERQA-ESFSR 511
            |||:                            |..||..:.|:           .|:|| |...|
Human   601 PKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRR 665

  Fly   512 LSKVDIE 518
            |..|.:|
Human   666 LLTVPVE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076	16/73 (22%)
		SANT	<194..240	CDD:304392	14/45 (31%)
		SANT	229..276	CDD:197842	18/47 (38%)
		Myb_DNA-binding	229..275	CDD:278669	18/46 (39%)
		Myb_DNA-bind_6	287..350	CDD:290632	16/62 (26%)
		SANT	392..438	CDD:197842	8/45 (18%)
		Myb_DNA-binding	393..437	CDD:278669	8/43 (19%)
SNAPC4	NP_001381130.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..82		6/29 (21%)
		SNAPC5-binding. /evidence=ECO:0000269\|PubMed:11056176	84..133		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..558		9/56 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..661		11/83 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1051
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1184..1266
		SNAPC2-binding. /evidence=ECO:0000269\|PubMed:11056176	1281..1393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1430..1449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6645
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006126
OrthoInspector	1	1.000	-	-		oto90699
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46621
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.850