Protein Alignment Pbp95 and MYBL1

DIOPT Version :10

• Sequence 1: NP_649760.1
• Gene: Pbp95 / 40949
• FlyBaseID: FBgn0037540
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_016868944.1
• Gene: MYBL1 / 4603
• HGNCID: 7547
• Length: 770
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 121/671 - (18%)
• Similarity: 204/671 - (30%)
• Gaps: 246/671 - (36%)

  Fly   205 DLEYRHSPY------SCEAMWRVYLTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASLDRRS 263
            ||:|....|      ..:.:|        .|..|:.:||:.|..:...:...:|.|||:.|..||
Human    26 DLQYADHDYEVPQQKGLKKLW--------NRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRS 82

  Fly   264 DYQCFVRFHTALRFLLEPKNSHRWSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGR 328
            |:||                .|||.:
Human    83 DFQC----------------QHRWQK--------------------------------------- 92

  Fly   329 YYYVLHPSISHEPFTTKEDMMLFAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDS 393
               ||:|.:...|:|.:||..:...|::|..|...........|...|.|.|:||.|....|..|
Human    93 ---VLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSS 154

  Fly   394 WSVQDDTRLMSFVTQYGASQWLNCATFLGNHTRTSCRTRF-LVIKKFLEQ-----------NPNA 446
            |:.::|..:.....:.| ::|...|..|...|..|.:..: ..:::.:||           ..::
Human   155 WTEEEDRIIYEAHKRLG-NRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSS 218

  Fly   447 KVEDLPRRRSKKVSLVNSDNWAQRLQEWQ-EDPES----------------LVNDNPPKGTRVR- 493
            |::..|......:...|......::..:| ..||.                .::::|.|..:::
Human   219 KLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKE 283

  Fly   494 --------GPKSKKARIERQAESFS--------------RLSKVDIEFCNFFKFSYNLTLSTPKT 536
                    ..:.::.||..|..|||              .|:.:|.....|:....|..:|..:.
Human   284 LEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQN 348

  Fly   537 FPVPKDVYNLAYVIRALAYKPPIRP--------SLLQNIFMPNDV------------LKCYNSMI 581
            .|..........|:.:|...|....        :|||:....:||            :|.....:
Human   349 SPTKFLAVEANAVLSSLQTIPEFAETLELIESFNLLQDPVAWSDVTSFDISDAAASPIKSTPVKL 413

  Fly   582 RNLPDEEGDMKSPLLPPNWSTMMGFRALCILSGDCRKDT--------------ETRSFEYNESLP 632
            ..:...||.|:..           |....:|.|  :|:|              ....|    |.|
Human   414 MRIQHNEGAMECQ-----------FNVSLVLEG--KKNTCNGGNSEAVPLTSPNIAKF----STP 461

  Fly   633 PIQLFRKR-----------------------------LQAL------FYRT---TLLSRLESQLF 659
            |..|.:||                             |:.|      |:.|   .....:|:..|
Human   462 PAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSF 526

  Fly   660 TDLP----SALVSLP-----RPKHDYAKMGTHVELI----------DPEP-----APQN------ 694
            |..|    .||::.|     .||.....:|.....|          .|.|     |.|.
Human   527 TSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPL 591

  Fly   695 DLKSEPLS--ENEVINTVKQE 713
            .:.|:||:  |.::...:|:|
Human   592 KIVSQPLAFLEEDIREVLKEE 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	SANT	<194..240	CDD:473887	9/40 (23%)
		SANT	229..276	CDD:197842	15/46 (33%)
		Myb_DNA-bind_6	287..350	CDD:372817	8/62 (13%)
		SANT	392..438	CDD:197842	9/46 (20%)
MYBL1	XP_016868944.1	Myb_DNA-bind_6	51..111	CDD:372817	24/117 (21%)
		PLN03091	97..>283	CDD:215570	34/186 (18%)
		Cmyb_C	504..660	CDD:462753	23/109 (21%)