DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp95 and Cdc5

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	126/623 - (20%)
Similarity:	219/623 - (35%)	Gaps:	221/623 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 WNQISTLDLEYRHSPYSCEAMWRVYLTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASLDRR 262
            |::|::  |.:|.|...|:|.|..:|.|.:::.:||.||||.||.:|.....| |..||..:.|.
  Fly    31 WSRIAS--LLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLAKLMPTQ-WRTIAPIIGRT 92

  Fly   263 SDYQCFVRFHTALRFLLEPKNSHRWSEEDNDKLRAI----VDRNTANSVINWKKVVEYFPDKSKS 323
            : .||..|:    .:||:........|:..|..|.:    :|.|.......        ||
  Fly    93 A-AQCLERY----EYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR--------PD---- 140

  Fly   324 TLIGRYYYVLHPSISHEPFTTKEDMMLFAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQR 388
                             |....||.:                      ..|::.|.|..|...::
  Fly   141 -----------------PKDMDEDEL----------------------EMLSEARARLANTQGKK 166

  Fly   389 NKTDSWSVQ-DDTRLMSFVTQYGASQWLNCATF-LGNHTR----------------------TSC 429
            .|..:...| ::.|.::.:.:   .:.|..|.. .||..|                      ||
  Fly   167 AKRKAREKQLEEARRLATLQK---RRELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHGFYDTS- 227

  Fly   430 RTRFLVIKKFLEQNP---------------NAKVEDLPRRRSKKVSLVNSDNWAQRLQEWQED-- 477
                   ::.|::|.               .::.|:..|:|.|           |:|::.:|:
  Fly   228 -------EEHLQKNEPDFNKMRQQDLDGELRSEKEERERKRDK-----------QKLKQRKENEV 274

  Fly   478 PESLVNDNPP--KGTRVRGPKSKKARIE-RQAESFSRLSKV--------DIEFCNFFKFSYNLT- 530
            |.:::.:..|  |.:::..|..:.:.:| :|.....|.|::        .||..:.....|::|
  Fly   275 PTAMLQNMEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITP 339

  Fly   531 --LSTPKTFPVP--KDVYNLAYVIRALAY-KPPIRPSLLQNIFMPNDVLKCYNSMIRNLPDEEGD 590
              .:||:| |.|  ..:...|..:.||.: :.|::..|                   |.|..|.|
  Fly   340 QVAATPRT-PAPYTDRIMQEAQNMMALTHTETPLKGGL-------------------NTPLHESD 384

  Fly   591 MKSPLLP-------PNW--------------STMMGFR-----ALCIL--SGDCRKDTETRSFEY 627
            . |.:||       ||.              :|..||:     ||..:  :|.......|.::..
  Fly   385 F-SGVLPKAASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAYVR 448

  Fly   628 NE-SLPPIQLFRKRLQALFYRTTLLSRLESQLFTDLPSALVSLPRPKHDYAKMGTHVELIDP--- 688
            :: |:.|.:..........|:     ..:.||.:.|...|.:||.|::||       |::.|
  Fly   449 DKLSINPEESMGVTETPAHYK-----NYQKQLKSTLRDGLSTLPAPRNDY-------EIVVPEQE 501

  Fly   689 ---------EPA--PQNDLKSEPLSENEVINTVKQELE 715
                     |||  .|.|:.:..|:|.|...  |:|||
  Fly   502 ESERIETNSEPAVEDQADVDARLLAEQEARR--KRELE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	16/41 (39%)
		SANT	229..276	CDD:197842	17/46 (37%)
		Myb_DNA-binding	229..275	CDD:278669	17/45 (38%)
		Myb_DNA-bind_6	287..350	CDD:290632	10/66 (15%)
		SANT	392..438	CDD:197842	9/69 (13%)
		Myb_DNA-binding	393..437	CDD:278669	9/67 (13%)
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	9/26 (35%)
		Myb_DNA-bind_6	11..71	CDD:290632	16/41 (39%)
		SANT_CDC5_II	56..108	CDD:212557	20/57 (35%)
		SANT	60..104	CDD:197842	17/49 (35%)
		Myb_Cef	397..648	CDD:288664	35/155 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900