DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp95 and rtf1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_594730.2	Gene:	rtf1 / 2541545	PomBaseID:	SPAC22F8.07c	Length:	466	Species:	Schizosaccharomyces pombe

Alignment Length:	411	Identity:	84/411 - (20%)
Similarity:	146/411 - (35%)	Gaps:	132/411 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 RKGTFRFKGNLFFRDIDGRSCPNNEDYEARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLL 156
            :.||..:|..:|.||                :|...||.:.:.|:.:...|.:..:.....:.||
pombe    81 KTGTTSYKDFVFSRD----------------YTNWTPTFWVLLSQLIDEFLKESELNFVAARDLL 129

  Fly   157 EHRAHSTNALPS-------------GSLKRKPIERHLSTLVSL-------LATADSSFSIDWNQI 201
                ..|..||.             .::.|:.:.|||....::       .....||.|...|.|
pombe   130 ----IKTKRLPKPFNNLLIQFQIQVPNVSRRTVYRHLKGYFNIPGYERFQYVKKASSGSWGANDI 190

  Fly   202 STLDLEYRHSPYSCEAMWRVYLTPDLRRDDWSPEEDETLLAVATANRMQN---------WELIAA 257
            .||:.|.        ||::       ::.:||   ||..|....::..::         :|||
pombe   191 ITLEKEI--------AMFK-------KKKNWS---DEQFLQYVWSDNHRDEMKTLYNCLYELI-- 235

  Fly   258 SLDRRSDYQCFVRFHTALRFLLEPKNSHRWSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSK 322
            ..|::|.|....|.:...      |...:|:.||..:|:.:|:::..    :|
pombe   236 DRDKKSIYNYLRRKYNPF------KKKCKWTIEDEAELKKLVEKHGT----SW------------ 278

  Fly   323 STLIGRYY-------------YVLHPSISHEPFTTKEDMMLFAAVEEYNGKFHCFPRSLFP---- 370
             :|||:..             |:....|:..|:|.:|...|...|.:|   ....|.|...
pombe   279 -SLIGKLSNRLPMHCRDHWRDYIQPGEINRSPWTIQEKEKLIKTVNQY---LQSNPSSPIQWSLI 339

  Fly   371 -----NRSLTQLRTRYHNVLAQ--RNKT-----DS-WSVQDDTRLMSF-VTQYGASQWLNCATFL 421
                 ||.....|.:|:.::::  .|.:     || |.::   |:|.. |.:.....| .|.:..
pombe   340 SKNMRNRHRHHCRWKYYTLISRDIHNSSPFKLGDSIWLIE---RMMDLNVAEERMIDW-KCLSEY 400

  Fly   422 GNH--TRTSCRTRFLVIKKFL 440
            .||  |..:|::.|..|||.|
pombe   401 ANHLWTADACKSHFERIKKTL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	12/45 (27%)
		SANT	229..276	CDD:197842	12/55 (22%)
		Myb_DNA-binding	229..275	CDD:278669	12/54 (22%)
		Myb_DNA-bind_6	287..350	CDD:290632	14/75 (19%)
		SANT	392..438	CDD:197842	14/49 (29%)
		Myb_DNA-binding	393..437	CDD:278669	12/47 (26%)
rtf1	NP_594730.2	REB1	1..466	CDD:227476	84/411 (20%)
		Myb_DNA-bind_6	259..318	CDD:290632	14/75 (19%)
		Myb_DNA-binding	307..359	CDD:278669	12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930