DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp95 and reb1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001342963.1	Gene:	reb1 / 2539930	PomBaseID:	SPBC1198.11c	Length:	504	Species:	Schizosaccharomyces pombe

Alignment Length:	465	Identity:	95/465 - (20%)
Similarity:	166/465 - (35%)	Gaps:	145/465 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NNEDYEARCHTEMFPT----DFDMHSRHVWTLLDKKNVIMGIKQQ----LLEHRAHSTNALPSGS 170
            ||.||......:..|.    :...:.|:...|:..:.....:.:|    .|:..|.|:.||.:.:
pombe    43 NNNDYSGSIEPKFSPALSIKEDGKNDRNFEALMSLQAQDSNLSEQNTSIHLDALASSSIALGNDN 107

  Fly   171 LKRKPIERHLSTLVSLLATADS-----SFSIDWNQISTLDLEYRHSPYSCEAMWRVYLTPDLRRD 230
            :........::..|:.:..:.|     |..|..::|:.:|               .:|....|
pombe   108 VDSSAFLSKVNKGVNAMRNSTSNQTNDSILISPSEITNMD---------------PFLKGSAR-- 155

  Fly   231 DWSPEEDETLLAVATANRMQNW--------ELIAASLDRR--------------SDYQCFVRFHT 273
             |:.|..:.|     ..||||:        ..:|.||..:              .:...|.| .|
pombe   156 -WTAEHWDYL-----ERRMQNFCQTYSLDHTQVADSLHEKRLHGPLSSLVKLLVQEMPSFTR-RT 213

  Fly   274 ALRFLLE-------PKNSHRWSEEDND---KLRAIVDRNTANSVIN--WKKVVEY------FPDK 320
            .||.|..       .|.|.:.|....|   :..||:.:...|.:::  |.   ||      :..|
pombe   214 ILRHLRALYNIPGYEKYSRKNSSGRGDFGVQETAIISQEVHNFIMDQGWS---EYQFCNQIWAGK 275

  Fly   321 SKSTLIGRYYYVLHPSISH--------------EPF------TTKEDMMLFAAVEEYNGKFHCFP 365
            ...| |..:|..|:..:||              .||      :.:||..|...|.|: ||  |:.
pombe   276 CPKT-IRMFYSNLYKKLSHRDAKSIYHHVRRAYNPFEDRCVWSKEEDEELRKNVVEH-GK--CWT 336

  Fly   366 R-----SLFPNRSLTQLRTRYHNVL--AQRNKTDSWSVQDDTRLMSFVTQYGASQ-------WLN 416
            :     :..||    ..|.|:.:|:  ..:.|.::||::::|:|:..|.:....:       |..
pombe   337 KIGRKMARMPN----DCRDRWRDVVRFGDKLKRNAWSLEEETQLLQIVAELRNREDLSSDINWTL 397

  Fly   417 CATFLGNHTRTSCRTRFLVIKKF-----LEQNP--NAKVEDLPRRRSKKVSLVNSD---NWAQRL 471
            .|..||..||..||.:|..:.|.     |::|.  ..::.|         ||:|:.   :|...:
pombe   398 VAQMLGTRTRLQCRYKFQQLTKAASKFELQENVWLLERIYD---------SLLNNGGKIHWENIV 453

  Fly   472 QE----WQED 477
            :|    |..|
pombe   454 KEANGRWTRD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	7/45 (16%)
		SANT	229..276	CDD:197842	13/68 (19%)
		Myb_DNA-binding	229..275	CDD:278669	13/67 (19%)
		Myb_DNA-bind_6	287..350	CDD:290632	19/93 (20%)
		SANT	392..438	CDD:197842	14/52 (27%)
		Myb_DNA-binding	393..437	CDD:278669	14/50 (28%)
reb1	NP_001342963.1	REB1	2..504	CDD:227476	95/465 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930