DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pbp95 and Dmtf1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_035936.3	Gene:	Dmtf1 / 23857	MGIID:	1344415	Length:	761	Species:	Mus musculus

Alignment Length:	774	Identity:	149/774 - (19%)
Similarity:	248/774 - (32%)	Gaps:	258/774 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 FFRDIDGR---SCPNNEDYEARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHRAHSTN 164
            |.:|.||.   .||.|:..|........|.    |.|...:..|.:::               .:
Mouse    21 FTQDTDGNLILHCPQNDPDEVDSEDSTEPP----HKRLCLSSEDDQSI---------------DD 66

  Fly   165 ALPSGSLKRKPI-ERHLSTLVSLLAT---ADSSFS---IDWNQISTLDLEYRHSPYSCE---AMW 219
            |.|..|:...|: |...|..|::.||   ||...|   :...||...|.....||...|   |:.
Mouse    67 ATPCISVVALPLSENDQSFEVTMTATTEVADDELSEGTVTQIQILQNDQLDEISPLGTEEVSAVS 131

  Fly   220 RVYLTPDLRRDD------------WSPEEDETLLAVATANRMQNW----------ELI-AASLDR 261
            :.:.|....:|.            ||.||.:.|:     |.::.:          |:| ..|.|.
Mouse   132 QAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILM-----NNIERYLKARGIKDATEIIFEMSKDE 191

  Fly   262 RSDY----------QCFVRFHTALRFLLEPKNSHRWSEEDNDKLR-------------------- 296
            |.|:          ..|..:...||...:..:..:::.|:.:||:
Mouse   192 RKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRS 256

  Fly   297 --AIVDR-----NTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMMLFAAV 354
              ::.||     :|.|:. .|.:..|           .|...|:|...|.||.......:.:|||
Mouse   257 ASSVKDRCRLMKDTCNTG-KWTEEEE-----------KRLAEVVHELTSTEPGDIVTQGVSWAAV 309

  Fly   355 EEYNGKFHCFPRSLFPNRSLTQLRTRYHNVL--AQRNKTDSWSVQDDTRLMSFVT---------- 407
            .|..|           .||..|.|:::.|.|  .|...|: |:.:|:..|:..:.
Mouse   310 AERVG-----------TRSEKQCRSKWLNYLNWKQSGGTE-WTKEDEINLILRIAELDVADENDI 362

  Fly   408 ---------------QYGASQWLNCATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRRSK 457
                           |:..|:|......:.||...|    |.|:.|.|:|....:..:.....:|
Mouse   363 NWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVS----FPVLIKGLKQLHENQKNNPVLLENK 423

  Fly   458 KVSLVNSDNWAQRLQEWQ------EDPESLVNDNPPKG-------TRVRGPKSKKARIERQAESF 509
            ..|.|.:.|....:|..|      || .:.::.:|...       |.|....|..|.::.:..:.
Mouse   424 SGSGVPNSNCNSSVQHVQIRVARLED-NTAISPSPMAALQIPVQITHVSSTDSPAASVDSETITL 487

  Fly   510 SRLSKVDIEFCNFFKF-------SYNLTLSTPKTFPVPKDVYNLAYVIRALAYKPP-------IR 560
            :..:....|....|..       :|.|..|:.:..|:.... |....:.|.|...|       :.
Mouse   488 NSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTT-NPTVTLAAAAPASPEQIIVHALS 551

  Fly   561 PSLLQNIFMPNDVLKCYNS--MIRNLPDEEGDMKSPLLPPNWSTMMGFRALCILSGDCRKDTETR 623
            |..|.|. ..|..::|:..  :|:.:..|  |:.|.|.....:.                |::..
Mouse   552 PEHLLNT-SDNVTVQCHTPRVIIQTVATE--DITSSLSQEELTV----------------DSDLH 597

  Fly   624 SFEYNESLPPIQLFRKRLQALFYRTTLLSRLESQLFTDLPSALVSLPRPK----------H---- 674
            |.::.|  ||                  ..||:..|.|      .:||||          |
Mouse   598 SSDFPE--PP------------------DALEADTFPD------EIPRPKMTIQPSFNNAHVSKF 636

  Fly   675 ---------DYAKMGTHVELID---PEPAPQNDLKS----EPLSENEVINTVKQELEME 717
                     :...:.|..|:.|   .:..|.:||.|    |.|....:::.|.|.::.|
Mouse   637 SDQNSTELMNSVMVRTEEEIADTDLKQEEPPSDLASAYVTEDLESPTIVHQVHQTIDDE 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	14/63 (22%)
		SANT	229..276	CDD:197842	14/79 (18%)
		Myb_DNA-binding	229..275	CDD:278669	14/78 (18%)
		Myb_DNA-bind_6	287..350	CDD:290632	15/89 (17%)
		SANT	392..438	CDD:197842	11/70 (16%)
		Myb_DNA-binding	393..437	CDD:278669	11/68 (16%)
Dmtf1	NP_035936.3	Interaction with CCND2	1..237		51/239 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..51		8/30 (27%)
		Required for DNA-binding	87..458		80/404 (20%)
		Required for transcriptional activation	87..170		21/87 (24%)
		REB1	<122..378	CDD:227476	50/284 (18%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000269\|PubMed:8887674	176..761		110/595 (18%)
		Myb_DNA-bind_6	228..284	CDD:372817	9/67 (13%)
		Myb_DNA-binding	274..329	CDD:365977	18/77 (23%)
		Required for transcriptional activation	459..761		50/283 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		14/82 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930