DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp95 and Dmtf1l

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_808373.1	Gene:	Dmtf1l / 237029	MGIID:	3045322	Length:	470	Species:	Mus musculus

Alignment Length:	416	Identity:	76/416 - (18%)
Similarity:	127/416 - (30%)	Gaps:	146/416 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PNNED--YEARCHTEMFPTDFDMHSRHVW---------TLLDKKNVIMGIKQQLLEHRAHSTNAL 166
            ||.|:  ......|.....|...|....|         |.:...|:...:|...:|:.|.....:
Mouse   100 PNKEESVVSQAWFTSKEAKDALTHQGQKWKQGMWSKEETAILMNNIERYMKDHGVENPAEIIFKM 164

  Fly   167 PSGSLKRKPIERHLSTLVSLLATADSSFSIDWNQISTLDLEYRHSPYSCEAMWRVYLTPDLRRDD 231
            ..|  |||...|.:|     |......||:           ||.       :.|:|       ||
Mouse   165 AKG--KRKDFYRSVS-----LGLNRPLFSV-----------YRR-------VVRMY-------DD 197

  Fly   232 ------WSPEEDETLLAVATANRMQNWELIAASLDRRSDY---QCFVRFHTALRFLLEPKNSHRW 287
                  :||||.|.|..: ......:|..|.|::.|....   :|        |.:.:..|:.:|
Mouse   198 RNHVGKYSPEEIEKLKEL-WQKHGNDWITIGAAMGRSPSSVKDRC--------RLMKDTCNTGKW 253

  Fly   288 SEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMMLFA 352
            :||:...|..:|...|...|                          ...::|.        :.:|
Mouse   254 TEEEEQLLGDVVHELTCTEV--------------------------DEKVTHG--------VCWA 284

  Fly   353 AVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTD-SWSVQDDTRLMSFVTQYGAS---- 412
            .|.:..|           .||..|.|.::.|.|..:.... .|:.:|:..|:..:.:...|
Mouse   285 TVAQRVG-----------TRSAKQCRAKWLNYLNWKQTGGIEWTRKDEVTLIQRLVELDVSDESE 338

  Fly   413 ----------------QWLNCATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRRSKKVSL 461
                            |||              |.::.:||:.:..:.:.....|.|...::...
Mouse   339 IRWDELAKGWESVRSPQWL--------------RNKWWIIKRQITNHKDFAFPVLVRCLQQEYES 389

  Fly   462 VNSDNWAQRLQEWQEDPESLVNDNPP 487
            .|:.     |:.|:....|.|.|:.|
Mouse   390 QNAS-----LRFWENKSGSEVPDSNP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392	13/51 (25%)
		SANT	229..276	CDD:197842	13/55 (24%)
		Myb_DNA-binding	229..275	CDD:278669	13/54 (24%)
		Myb_DNA-bind_6	287..350	CDD:290632	8/62 (13%)
		SANT	392..438	CDD:197842	9/66 (14%)
		Myb_DNA-binding	393..437	CDD:278669	8/63 (13%)
Dmtf1l	NP_808373.1	SANT	202..247	CDD:197842	12/53 (23%)
		Myb_DNA-bind_6	205..261	CDD:290632	16/64 (25%)
		SANT	251..307	CDD:197842	16/100 (16%)
		Myb_DNA-binding	251..306	CDD:278669	16/99 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930