DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pbp95 and Ttf1

DIOPT Version :9

Sequence 1:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_036016405.1	Gene:	Ttf1 / 22130	MGIID:	105044	Length:	867	Species:	Mus musculus

Alignment Length:	745	Identity:	139/745 - (18%)
Similarity:	244/745 - (32%)	Gaps:	276/745 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DADDLRINQQQLMDEISALLQNT-----AKPSAANALQLNQELQRRLMQVRTKILAMLQVVRARF 62
            |.|.:.::..:  .:.||.::.|     |||......:|..:::.|..|...:.:|...||:.
Mouse   243 DVDIVYVDMSK--GQRSAKVRETGELPAAKPQEHGCRELLGDVRSRKKQKHLQKVAPWDVVQG-- 303

  Fly    63 SRNEDILVRRLRPRSHFGPNSLNLSGAILRKGTF---RFKGNLFFRDIDGRSCPNNEDYEARCHT 124
            |:.|.|.:....|.|     |.:|.|.......|   :.|.|:|      ||          ...
Mouse   304 SQPESISLPPSEPLS-----SEDLEGKSTEAAVFCKKKSKKNVF------RS----------QEL 347

  Fly   125 EMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHRAHSTNALPSG----------SLKRK-PIER 178
            |..|...| .|..:...||.               .|...|:.:|          |:|:| ..::
Mouse   348 EPIPDSLD-DSETISERLDS---------------THHGGAVGAGEECESTKESHSIKKKSKKKK 396

  Fly   179 HLSTLVSLLATADSSFSIDWNQISTL-------------DLEYRHS---PYSC------EAMWRV 221
            |.|  |:|..::||:...|....:.|             |:::|.:   ..:|      |||.|:
Mouse   397 HKS--VALATSSDSASVTDSKAKNALVDSSEGSGAVREEDVDHRPAEAEAQACSTEKHREAMQRL 459

  Fly   222 -------------------YLTPDLRRDDWS---------------PEEDETLLAVATANRMQNW 252
                               :::.|.|..|.|               |:..|.  |..|..||.
Mouse   460 EPTHEEESNSESASNSAARHISEDRRESDDSDVDLGSAVRQLREFIPDIQER--AATTIRRMY-- 520

  Fly   253 ELIAASLDRRSDYQCFVRFH---TALRFLLEPKNSHRWSEEDNDKL-RAIVDRNTANSVINWKKV 313
                     |.|...|..|.   .|:||       .::|.::|.:: :.:.|..:...:.:..|:
Mouse   521 ---------RDDLGRFKEFKAQGVAIRF-------GKFSAKENKQIEKNVQDFLSLTGIESADKL 569

  Fly   314 V--EYFPDKSKSTLI----GRYYYVLHPSISHEPFTTKEDMMLFAA-----VEEYNGK------- 360
            :  :.:|:  :.|||    .::.:.||..   :.......::.:.|     |..|.|:
Mouse   570 LYTDRYPE--EKTLITNLKRKHAFRLHIG---KGIARPWKLVYYRAKKIFDVNNYKGRYNEEDTK 629

  Fly   361 ----FHCFPRSLFPN----------RSLTQLRTRYHNVLAQRNKTDSWSVQDDTRLMSFVTQYGA 411
                :|    ||..|          ||...:..::..:...||: .:||..:..||:..|..
Mouse   630 KLKAYH----SLHGNDWKKIGAMVARSSLSVALKFSQIGGTRNQ-GAWSKAETQRLIKAVED--- 686

  Fly   412 SQWLNCATFLGNHTRTSCRTRFLVIKKF-----------LEQNPNAKVEDLPRRRSKKVSLVNSD 465
                                  :::||.           |:::|..::..:..:..|.:|.|..:
Mouse   687 ----------------------VILKKMSPQELRELDSKLQEDPEGRLSIVREKLYKGISWVEVE 729

  Fly   466 ------NWAQRLQEWQEDPESLVNDNPPKGTRVRGPKSKKAR---IER-------QAESFSRLSK 514
                  ||.|...:|   .|.|.......|...||..:.:|:   |||       ||: |.:|..
Mouse   730 ARVETRNWMQCKSKW---TEILTKRMTHGGFVYRGVNALQAKITLIERDVPPPFVQAK-FYKLKA 790

  Fly   515 VDIEFCNFFKFSYNLTLSTPKTFPVPKDVYNLAYVIRALAYKPPI------------RPSLLQNI 567
            ..:.|..            .||||   ::.:..|.......|..:            .|:..:..
Mouse   791 ACVPFWQ------------KKTFP---EIIDYLYKNSLPLLKEKLDKKMKKKDGQIQTPAAPKQD 840

  Fly   568 FMPNDVLKCYNSMIRNLPDEEGDMKSPLLP 597
            |:..|:..|         |::.|..||..|
Mouse   841 FLFKDIFHC---------DDDSDEGSPEEP 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076	16/74 (22%)
		SANT	<194..240	CDD:304392	15/101 (15%)
		SANT	229..276	CDD:197842	13/64 (20%)
		Myb_DNA-binding	229..275	CDD:278669	12/63 (19%)
		Myb_DNA-bind_6	287..350	CDD:290632	10/69 (14%)
		SANT	392..438	CDD:197842	5/45 (11%)
		Myb_DNA-binding	393..437	CDD:278669	5/43 (12%)
Ttf1	XP_036016405.1	Myb_DNA-bind_6	625..680	CDD:372817	10/59 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900