Protein Alignment CG10435 and Ubap1

DIOPT Version :10

• Sequence 1: NP_649759.1
• Gene: CG10435 / 40948
• FlyBaseID: FBgn0037539
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001012190.1
• Gene: Ubap1 / 362502
• RGDID: 1305186
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 125/538 - (23%)
• Similarity: 205/538 - (38%)
• Gaps: 138/538 - (25%)

  Fly     1 MEDVPVKIVERYKPP-----PAVYHLPQATLNRLSQFREGFYTDHPDYQYDCQLERAVLSQAQRW 60
            ::|||.||.:::|.|     |..:.||..    |...||        .|||..||:..:..|:..
  Rat    17 LDDVPFKIGDKFKTPAKVGLPIGFSLPDC----LQVVRE--------MQYDFSLEKKAIEWAEDI 69

  Fly    61 RHLRRQQREERASRQERRKEERQRALEARQKEMLGAVDYPSADDLSSDEDEKERKKNEPEQRDEE 125
            |.::..|:|     .||:.||    .||:.....|    |..|...|..     |.:.|...
  Rat    70 RLIQEAQQE-----AERKSEE----AEAKVNSKSG----PEGDSKVSFS-----KTHSPATM--- 113

  Fly   126 QQQQPPPPITAESRDSSHEPKSISVCNFHNILQPTILSTT----PVVSPQTLHKRNSSLNYADFE 186
                 ||||........|          :|||.||.:|::    .|:||.  |.: :..|.||||
  Rat   114 -----PPPINPILASLQH----------NNILTPTRVSSSATKQKVLSPP--HTK-ADFNPADFE 160

  Fly   187 YNMNSTPFDNIELKTINDLD------------ILAQVLHQT----------QLEKRIDQQQQDQQ 229
              ....||||:|||||::.:            |:||:|...          |.|:.:...:|...
  Rat   161 --CEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNTPRGNSGSVLQDEEVLASLEQATL 223

  Fly   230 QQEPPHEDHS--KEEQSGN----EVPAPVEL-AMTTLAETKA----TLDSVNFHVHCDDNADRGE 283
            ..:|.|:.:.  ...|.||    .:.:.|.| .:.|::..|:    .|||       ||::.:
  Rat   224 DFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDS-------DDSSQK-- 279

  Fly   284 PSHIPTTAQYLTPMYSASAQQPLHKPEHFQVYHMQGYSHQPFYPPQQHSFQQFSNYQVNGFGTQN 348
                  |.:..:..:|.|..:             .|.|.....|..|.|..:.:.....|....|
  Rat   280 ------TVRLASTFHSTSCLR-------------SGASRNFLKPSTQSSASELNGDHALGLSALN 325

  Fly   349 LLKAP--PAPSSVHALSQSEDEVATKSRSVPDILRELKTELQQAEKRRTRLHSHNAEQQPTVELA 411
            |....  ||.:|....|.|...|.|:..|.|.....: |.|           :.:..|.||:...
  Rat   326 LNSGTEVPALTSSQMPSLSILSVCTEESSPPSTCPTV-TPL-----------NFSVSQVPTMPSC 378

  Fly   412 VDRNSFRELAGPAQK-LAQRISTMGFPLERVAKVVSLCGIDDKKIIEHLIPLGELLDLGFDESKI 475
            .......:...|::: ..:.:..||:..:.|.:.:...|.:.::|:::|...|:|.:.|||...:
  Rat   379 PQAYLELQALSPSERQCVETVVNMGYSYDCVLRAMKKKGENIEQILDYLFAHGQLCEKGFDPLLV 443

  Fly   476 SAALLKFNNNKDKALDYL 493
            ..||.....:::|.:::|
  Rat   444 EEALEMHQCSEEKMMEFL 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10435	NP_649759.1	UBA2_UBAP1_like	458..494	CDD:270501	10/36 (28%)
Ubap1	NP_001012190.1	Interaction with ESCRT-I. /evidence=ECO:0000250|UniProtKB:Q9NZ09	1..95		28/98 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..120		17/68 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	135..156		5/23 (22%)
		Interaction with PTPN23. /evidence=ECO:0000250|UniProtKB:Q9NZ09	260..290		7/44 (16%)
		UBA1_UBAP1	388..430	CDD:270500	7/41 (17%)
		UBA2_UBAP1_like	460..496	CDD:270501	1/2 (50%)