DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2767 and AKR7L

DIOPT Version :9

Sequence 1:	NP_649757.1	Gene:	CG2767 / 40946	FlyBaseID:	FBgn0037537	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001335350.1	Gene:	AKR7L / 246181	HGNCID:	24056	Length:	331	Species:	Homo sapiens

Alignment Length:	323	Identity:	71/323 - (21%)
Similarity:	114/323 - (35%)	Gaps:	117/323 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AALEAGYRHIDTAPVY--GNEKAI--GRVLKRWLDAGKVKREELFIVTKVPP-VSN--RPHEVEP 93
            |.||.|:..||||.:|  |..:.|  |..|:......:||     |.||..| :.|  :|..|..
Human    34 AFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK-----IATKANPWIGNSLKPDSVRS 93

  Fly    94 TIKKSLEDLQLDYVDLYLVHTPFTININEDGSFKLDKEGLMEVDVTTNHAAIWVAMEALVEKGLT 158
            .::.||:.||...|||:.:|.|             |....:|..:...|        .|.::|..
Human    94 QLETSLKRLQCPRVDLFYLHAP-------------DHSAPVEETLRACH--------QLHQEGKF 137

  Fly   159 KSIGVSNFSKDQVARLLKNCKIRPANNQIEHHVY---------LQQRDLVDFCKSENITVTAYSP 214
            ..:|:||::..:||.:...||   :|..|...||         ..:.:|....:...:...||:|
Human   138 VELGLSNYAAWEVAEICTLCK---SNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNP 199

  Fly   215 L---------------GSKGIAKFNA------------------GAGIVRDLPDLMDIPEVKEIA 246
            |               |.:.:.:|..                  |..:|.           |.:.
Human   200 LAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVE-----------KALQ 253

  Fly   247 ASHGKTP---AQVLLRWI-------------IDTGVSAIPKSTNPARLKQNLDVFDFELTAEE 293
            |::|.:.   ....|||:             :..|:|::      .:|:|||      ..|||
Human   254 AAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSL------EQLEQNL------AAAEE 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2767	NP_649757.1	ARA1	5..302	CDD:223729	71/323 (22%)
CG2767	NP_649757.1	Tas	10..297	CDD:223739	71/323 (22%)
AKR7L	NP_001335350.1	Aldo_ket_red	10..318	CDD:119408	71/323 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910