DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2698 and Tmem245

DIOPT Version :9

Sequence 1:	NP_001246976.1	Gene:	CG2698 / 40945	FlyBaseID:	FBgn0037536	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	XP_011248339.1	Gene:	Tmem245 / 242474	MGIID:	2445107	Length:	888	Species:	Mus musculus

Alignment Length:	905	Identity:	247/905 - (27%)
Similarity:	400/905 - (44%)	Gaps:	182/905 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RAAMYNFLIAAGVAAFVAVC--------FILGPFVRPLLWAFLMGAVLFPFKRRLAESVNSWFHR 90
            :.|.||    .|...||.:|        |||..|:||||||.|.|..|.|||..|......|..|
Mouse    47 KQAFYN----TGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRLWLRR 107

  Fly    91 LEVRDSNVLVSICLSPLEATEH---------------------CGRLLIGWLC----EHWQLLLA 130
            |....:.::::..|.||...::                     .|.||.|..|    ...|:|||
Mouse   108 LHRAHTPIVLAALLLPLCFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLLA 172

  Fly   131 GCGVAGCIKLLVLYAPKGFLLAIWHWITFSHGLFVQIIGFLNVYVLISLIVVYLSCVHFFWRPEN 195
            ..|...|..|       .:..::|.|                     :|:|.|:..|.|.|....
Mouse   173 HAGALICRGL-------DYFSSLWIW---------------------TLVVGYVLMVSFKWNAST 209

  Fly   196 SAHFVVAGQSMWIAVAGYLSSFLGALQVPVFLLVMTYVTASTAYHLQTLDDS------GSYLHRL 254
            ..:.......:|:.:..:::|..|:.::||||:::..::..|.|..|...:|      |..:...
Mouse   210 QRYLRAVSIPVWMILLFHIASLAGSWRIPVFLVIVFLMSVGTLYEKQNEKESAGAELPGQVISMA 274

  Fly   255 QKLFDKNDFERSLSNFSICGRPGNEPLSPGLQSDVEDVSLSDTVDSTDTFDVKPETEVPSHQ--- 316
            ..         :|:|.:|.        ..|.:|..||.......:.||..:..|.....|..
Mouse   275 AS---------TLANLAIS--------ITGYESSTEDQPSDPPTEPTDKGEPPPALSASSSSSSR 322

  Fly   317 --------------------------SDTFFKLLFYACLGTFLYRNVWMFILAAIPVILHLIYTV 355
                                      ||.:|..|.:|.:...|:.|:|:..|..:||.:.:|..:
Mouse   323 SSPSSPSPTLGRQRPEMGTFLRKKKTSDIYFVSLVWAIIAVQLWLNLWIVQLLPVPVAVWIIKKL 387

  Fly   356 GEYTGITKFVCNKISEVYAALRFWAIEHHSAVLPLCLPG----VLELNYK----INTIVRDSLKA 412
            ..:.|:..|:..:....:..:..:..|...|:.|..:.|    :|:::.|    :|..:...|:.
Mouse   388 VIHFGVVGFLEKRCHAWWQVIECFLKERQEALAPWPIIGLGKFLLKVDSKLWHWLNKKMIIWLEK 452

  Fly   413 SVESVTSILMIILMLLIIVFLSVFFCVNIYSETIEVAYLGKDLINKTITDRPELIDILPAN--MQ 475
            .::.:.||.:|.|:::..:.|::.....::.|::.:..:...|||:|:.:.||..:.||..  :|
Mouse   453 MLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSSLINETLANHPEWANWLPEAQVVQ 517

  Fly   476 SSIEDALDNAHHYGRRKIETYIDDWLAD------ADKVHATK-LKEQILEVWDRLIQYWI--DFN 531
            .::..|.:|.:.|||        :|:..      .|||:.|. :::|:||:||||...|.  :..
Mouse   518 RALNSAANNVYQYGR--------EWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVT 574

  Fly   532 KAGSSYGPRVPTDALKSTFGEIVDNPELVLVAKQGIIGWAQSNTQTIL------------EVAES 584
            .:|...|.::......|..|:|:|        .|.|..:...|.:|.|            ::.||
Mouse   575 HSGRHKGHKMHVSRQNSWLGDILD--------WQDIASFVHENIETFLSILSFGFQIWKMKILES 631

  Fly   585 LWHIIRTNMSMIMGVTGEILSLVLSGGQACIEFILDMIVFFTALFYLLSSSQEKYAP----LQIT 645
            ||.::..|:|::......:|:::...|.|.:.|:|.:|:|.|.||||||||.|.|.|    :.:|
Mouse   632 LWIVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLT 696

  Fly   646 KYLGYSSSGIKIADALENSITVVLVSMFRCSTFTGLFTWLVHTVFGARIVFLPSALAAMLAAAPF 710
            .......|...|..::|.:|..|..:..:.:.|.||:|||.||:||..|||:||||||:|.|.||
Mouse   697 PLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPF 761

  Fly   711 LGSYWCAVPAFLELWLAQDRFYAGL----ILFLLQFFVPSSF-ETAIYADLK-GGHPYLNGLAIA 769
            ||:||.||||.|:|||.|     ||    ||.|:...:|:.| :||||:|:. ||||||.|||:|
Mouse   762 LGTYWAAVPAVLDLWLTQ-----GLGCKAILLLVFHLLPTYFVDTAIYSDISGGGHPYLTGLAVA 821

  Fly   770 GGMYWIGWQGAIFGPLMLCFFIGLFEVATLAMRSHQEPRNSTDEERTTSIPRRVNETVND 829
            ||.|::|.:|||.||::||..:....:.:..:.|   |.||......|..|.:...|..|
Mouse   822 GGAYYLGLEGAIIGPILLCILVVASNIYSAMLVS---PTNSMPTPNQTPWPAQTQRTFRD 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2698	NP_001246976.1	DUF4400	146..>216	CDD:301307	9/69 (13%)
CG2698	NP_001246976.1	UPF0118	<561..795	CDD:294317	105/255 (41%)
Tmem245	XP_011248339.1	AI-2E_transport	<659..849	CDD:294317	92/194 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41841
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2398
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48733
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005464
OrthoInspector	1	1.000	-	-		oto93341
orthoMCL	1	0.900	-	-		OOG6_105649
Panther	1	1.100	-	-	LDO	PTHR21716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3860
SonicParanoid	1	1.000	-	-		X5059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790