DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2698 and TMEM245

DIOPT Version :9

Sequence 1:	NP_001246976.1	Gene:	CG2698 / 40945	FlyBaseID:	FBgn0037536	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_114401.2	Gene:	TMEM245 / 23731	HGNCID:	1363	Length:	879	Species:	Homo sapiens

Alignment Length:	886	Identity:	249/886 - (28%)
Similarity:	411/886 - (46%)	Gaps:	157/886 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RAAMYNFLIAAGVAAFVAVC--------FILGPFVRPLLWAFLMGAVLFPFKRRLAESVNSWFHR 90
            :.|.||    .|...||.:|        |||..|:||||||.|.|..|.|||..|......|..|
Human    51 KQAFYN----TGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQR 111

  Fly    91 LEVRDSNVLVSICLSPLEATEHCGRLLIG--WLCEHWQLLLAGCG---VAG--C------IKLLV 142
            |....:.::::..|.||...:: |...:|  .|.....|||.|.|   :.|  |      :::|:
Human   112 LHRAHTPIVLAALLLPLCFVDY-GVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLL 175

  Fly   143 LYAP----KG--FLLAIWHWITFSHGLFVQIIGFLNVYVLISLIVVYLSCVHFFWRPENSAHFVV 201
            ::|.    :|  :..::|.|                     :|:|.|:..|.|.|......:...
Human   176 VHAATLICRGLDYFSSLWIW---------------------TLVVGYVLTVSFKWNASTERYLRA 219

  Fly   202 AGQSMWIAVAGYLSSFLGALQVPVFLLVMTYVTASTAYHLQTLDDS------GSYLHRLQKLFDK 260
            ....:||.:..:|:|..|:.::||||:::..::..|.|..|...:|      |..:.....
Human   220 VSIPVWIILLFHLASLAGSWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAAS---- 280

  Fly   261 NDFERSLSNFSICGRPGNEPLSPGLQSDVED------VSLSDTVDSTDTFDVKPETEVPS----- 314
                 :|:|.:|.        ..|.:|..||      ....|..:|..|....|....||
Human   281 -----TLANLAIS--------ITGYESSSEDQPSTQPAEAVDRGESAPTLSTSPSPSSPSPTSPS 332

  Fly   315 -----------------HQSDTFFKLLFYACLGTFLYRNVWMFILAAIPVILHLIYTVGEYTGIT 362
                             ..||.:|..|.:|.:...::.|:|:..|..:|:.:.::..:..:.|:.
Human   333 PTLGRRRPEIGTFLRKKKTSDIYFVSLVWAIVVMQIWLNLWIVQLLPVPIAVWILKKLVIHFGVV 397

  Fly   363 KFVCNKISEVYAALRFWAIEHHSAVLPLCLPG----VLELNYK----INTIVRDSLKASVESVTS 419
            .|:..:....:..:..:..|...|:.|..:.|    :|:::.|    :|..:...|:..::.:.|
Human   398 DFLEKRYHVWWGIIESFLKERQGALAPWPIVGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIIS 462

  Fly   420 ILMIILMLLIIVFLSVFFCVNIYSETIEVAYLGKDLINKTITDRPELIDILPAN--MQSSIEDAL 482
            |.:|.|:::..:.|::.....::.|::.:..:..:|||:|:.:.||..:.||..  :|.::..|.
Human   463 IFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAA 527

  Fly   483 DNAHHYGRRKIETYIDDWLAD------ADKVHATK-LKEQILEVWDRLIQYWI--DFNKAGSSYG 538
            :|.:.|||        :|:..      .|||:.|. :::|:||:||||...|.  :...:|...|
Human   528 NNVYQYGR--------EWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVTHSGRHKG 584

  Fly   539 PRVPTDALKSTFGEIVDNPELVLVAKQGIIGWAQSNTQTILEVAESLWHIIRTNMSMIMGVTGEI 603
            .::......|..|:|:|        .|.|:.:...|.:|.|.:.||||.::..|:|::......:
Human   585 QKLHVSRQNSWLGDILD--------WQDIVSFVHENIETFLSILESLWIVMSRNVSLLFTTVTTL 641

  Fly   604 LSLVLSGGQACIEFILDMIVFFTALFYLLSSSQEKYAP----LQITKYLGYSSSGIKIADALENS 664
            |:::...|.|.:.|:|.:|:|.|.||||||||.|.|.|    :.:|.......|...|..::|.:
Human   642 LTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEA 706

  Fly   665 ITVVLVSMFRCSTFTGLFTWLVHTVFGARIVFLPSALAAMLAAAPFLGSYWCAVPAFLELWLAQD 729
            |..|..:..:.:.|.||:|||.||:||..|||:||||||:|.|.||||:||.||||.|:|||.|
Human   707 IRGVFDASLKMAGFYGLYTWLTHTMFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQ- 770

  Fly   730 RFYAGL----ILFLLQFFVPSSF-ETAIYADLK-GGHPYLNGLAIAGGMYWIGWQGAIFGPLMLC 788
                ||    ||.|:...:|:.| :||||:|:. ||||||.|||:|||.|::|.:|||.||::||
Human   771 ----GLGCKAILLLIFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLC 831

  Fly   789 FFIGLFEVATLAMRSHQEPRNSTDEERTTSIPRRVNETVND 829
            ..:....:.:..:.|   |.||......|..|.:...|..|
Human   832 ILVVASNIYSAMLVS---PTNSVPTPNQTPWPAQPQRTFRD 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2698	NP_001246976.1	DUF4400	146..>216	CDD:301307	12/75 (16%)
CG2698	NP_001246976.1	UPF0118	<561..795	CDD:294317	105/243 (43%)
TMEM245	NP_114401.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..339		9/45 (20%)
		AI-2E_transport	<594..840	CDD:294317	109/258 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154903
Domainoid	1	1.000	142	1.000	Domainoid score	I4703
eggNOG	1	0.900	-	-		E1_KOG2365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41841
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2411
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48733
OrthoDB	1	1.010	-	-		D123277at33208
OrthoFinder	1	1.000	-	-		FOG0005464
OrthoInspector	1	1.000	-	-		oto89769
orthoMCL	1	0.900	-	-		OOG6_105649
Panther	1	1.100	-	-	LDO	PTHR21716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3860
SonicParanoid	1	1.000	-	-		X5059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800