DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2698 and tmem245

DIOPT Version :9

Sequence 1:	NP_001246976.1	Gene:	CG2698 / 40945	FlyBaseID:	FBgn0037536	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	XP_012809274.1	Gene:	tmem245 / 100124972	XenbaseID:	XB-GENE-5898567	Length:	870	Species:	Xenopus tropicalis

Alignment Length:	840	Identity:	237/840 - (28%)
Similarity:	402/840 - (47%)	Gaps:	108/840 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRSEPIPIRRDRSFDSVINRLLRMRSQNHESFRAAMYN---FLIAAG-VAAFVAVCFILGPFVR 61
            ::.|:.:|:|.||                  :.:.|.||   .|.||| ..|.|.|.|||..|:|
Frog    57 LSLSQALPLRFDR------------------NIKQAFYNTGALLFAAGCCGAAVLVYFILEAFLR 103

  Fly    62 PLLWAFLMGAVLFPFKRRLAESVNSWFHRLEVRDSNVLVSICLSPL----EATEHCG-------R 115
            |||||.|.|..|.|||..|......|..||:.:.|.:.::..|.|:    ::.|..|       |
Frog   104 PLLWAALCGTFLHPFKTSLTGVGRRWLIRLQRQGSPIFLATFLLPVSFANQSLEALGEQVTRRLR 168

  Fly   116 LLIGWLCEHWQLLLAGCGVAGCIKLLVLYAPKGFLLAIWHWITFSHGLFVQIIGFLNVYVLISLI 180
            :|:        |||||..:..||.|...:      |.:..::....||....:...:...:.:|:
Frog   169 VLV--------LLLAGAPILYCIYLAASH------LGVQEFLGNICGLICGALDCFSSQWIWTLV 219

  Fly   181 VVYLSCVHFFWRPENSAHFVVAGQSMWIAVAGYLSSFLGALQVPVFLLVMTYVTASTAYHLQ-TL 244
            :.|...|.|.|..:...:.......:|:.:..:.:|..|:.::|||||::..:|..:.:..| |.
Frog   220 IGYTLAVSFKWNADTQNYLTAISVPVWLVLLFHFASVCGSWKIPVFLLIVFLMTLGSLHEKQNTH 284

  Fly   245 DDSGSYL---------HRLQKLFDKNDFERSLSNFSICGRPGNEPLSPGLQSDVEDVSLSDTVDS 300
            ..||:.|         ..:......:.||.....|     |..:|....:......:.|......
Frog   285 GSSGTVLPGQIFTIAASTIAMAISISGFEEHQEGF-----PTAQPTEAQMDEPPSTLLLGRQKSE 344

  Fly   301 TDTFDVKPETEVPSHQSDTFFKLLFYACLGTFLYRNVWMFILAAIPVILHLIYTVGEYTGITKFV 365
            ...|..:.:|      ||.:|.:|.:|.:...::.|:|:..:..:|:.:..|..:..:.|:..|:
Frog   345 IGEFLKRKKT------SDIYFVVLMWAIVVVQIWLNLWIIQILPVPIAVFAIKKLLIHFGVANFL 403

  Fly   366 CNKISEVYAALRFWAIEHHSAVLPLCLPG----VLELNYK----INTIVRDSLKASVESVTSILM 422
            .|.....:..:..:..|...|:.|..:.|    :|:.:.|    :|..:...|:.|::.:.||.:
Frog   404 VNHCGSWWKVIEDFVKERQEALAPRPIRGLARFILKADCKMWHWLNEQMIIWLEKSLDKIISIFI 468

  Fly   423 IILMLLIIVFLSVFFCVNIYSETIEVAYLGKDLINKTITDRPELIDILPAN--MQSSIEDALDNA 485
            |.::::..:.|::|....::.|::.:..:..:|||:|::..||..:.||..  :|.::..|.:|.
Frog   469 IFMLVIGTLLLALFLTAKVHEESVHIIEVTSNLINETVSSHPEWANWLPEAQVVQKALNSAANNV 533

  Fly   486 HHYGRRKIETYIDDWLAD------ADKVHATK-LKEQILEVWDRLIQYWI--DFNKAGSSYGPRV 541
            :.|||        :|:..      .:||:.|. :::|:||:||||...|:  :....|...|.::
Frog   534 YQYGR--------EWITHKLHKIFGEKVNNTAVIEKQVLELWDRLYHSWVIKNITHPGRHKGHKM 590

  Fly   542 PTDALKSTFGEIVDNPELVLVAKQGIIGWAQSNTQTILEVAESLWHIIRTNMSMIMGVTGEILSL 606
            ......|..|:|:|        .|.|..:...|.:|.|.:.||||.::..|:|::......:|::
Frog   591 QIQRQNSWLGDILD--------WQDIASFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTV 647

  Fly   607 VLSGGQACIEFILDMIVFFTALFYLLSSSQEKYAP----LQITKYLGYSSSGIKIADALENSITV 667
            :...|.|.:.|:|.:::|.|.||||||||.|.|.|    :.:|.......|...|..::|.:|..
Frog   648 IFYSGTALLNFVLSLVIFLTTLFYLLSSSDEYYKPVKWLISLTPLSQPGPSSNIIGQSVEEAIRG 712

  Fly   668 VLVSMFRCSTFTGLFTWLVHTVFGARIVFLPSALAAMLAAAPFLGSYWCAVPAFLELWLAQDRFY 732
            |..:..:.:.|.||:|||.||:||..|||:||||||:|.|.||||:||.|:||.|:||.||....
Frog   713 VFDASLKMACFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAIPAVLDLWFAQGENC 777

  Fly   733 AGLILFLLQFFVPSSFETAIYADLK-GGHPYLNGLAIAGGMYWIGWQGAIFGPLMLCFFI 791
            ..::|.|.........:||||:|:. ||||||.|||:|||.|::|.:|||.||::||..:
Frog   778 KAVLLLLCHLLPTYCVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCVLV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2698	NP_001246976.1	DUF4400	146..>216	CDD:301307	9/69 (13%)
CG2698	NP_001246976.1	UPF0118	<561..795	CDD:294317	98/236 (42%)
tmem245	XP_012809274.1	AI-2E_transport	<591..843	CDD:294317	102/255 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4265
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41841
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2291
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123277at33208
OrthoFinder	1	1.000	-	-		FOG0005464
OrthoInspector	1	1.000	-	-		oto103578
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060