DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ELOVL and ELOVL4

DIOPT Version :9

Sequence 1:	NP_649754.1	Gene:	ELOVL / 40943	FlyBaseID:	FBgn0037534	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_073563.1	Gene:	ELOVL4 / 6785	HGNCID:	14415	Length:	314	Species:	Homo sapiens

Alignment Length:	287	Identity:	125/287 - (43%)
Similarity:	181/287 - (63%)	Gaps:	14/287 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SDPRTRDYPLMSSPFPTIAISLTYAYIVKVLGPKLMENRKPFELRKVLIVYNAAQVIFSAWLFYE 83
            :|.|..::|||.||:||::||..|...| .||||.|::|:||::|.|||:||...|:.:.::|.|
Human    33 ADKRVENWPLMQSPWPTLSISTLYLLFV-WLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRE 96

  Fly    84 SCIGGWLNGYNLRCEPVNYSYSPKAIRTAEGCWWYYFSKFTEFFDTFFFVMRKRYDQVSTLHVIH 148
            ..:|.:..||:..|:.|:||.:...:|.|...|||:.||..|:.||.||::||:.:|||.|||.|
Human    97 LFMGSYNAGYSYICQSVDYSNNVHEVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYH 161

  Fly   149 HGIMPVSVWW-GVKFTPGGHSTFFGFLNTFVHIFMYAYYMLAAMGPKVQKYLWWKKYLTVMQMIQ 212
            |..| .::|| |:|:..||.:.|...||:|:|:.||:||.|.|.||.:|||||||:|||::|:||
Human   162 HCTM-FTLWWIGIKWVAGGQAFFGAQLNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLIQ 225

  Fly   213 FVLVMVHSFQLFFKNDCNYPIGFAYFIGAHAVMFYFLFSNFYKRAYVKRDGKDKASVKA-NG-HA 275
            |.:.:.|: .|....||.:|....:.:.|:|:.|.|||.|||.|.| |...|.||...| || .|
Human   226 FHVTIGHT-ALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYIRTY-KEPKKPKAGKTAMNGISA 288

  Fly   276 NGHVKA-----LKDGDVAPTSNGQANG 297
            ||..|:     :::|  ....||:|.|
Human   289 NGVSKSEKQLMIENG--KKQKNGKAKG 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELOVL	NP_649754.1	ELO	27..266	CDD:366492	109/239 (46%)
ELOVL4	NP_073563.1	ELO	41..278	CDD:279492	109/240 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..314		15/41 (37%)
		Di-lysine motif. /evidence=ECO:0000255\|HAMAP-Rule:MF_03204	310..314		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3071
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094172at2759
OrthoFinder	1	1.000	-	-		FOG0000078
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100254
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R389
SonicParanoid	1	1.000	-	-		X54
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750