DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD98hc and IMA3

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_012096.1	Gene:	IMA3 / 854635	SGDID:	S000001434	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	439	Identity:	88/439 - (20%)
Similarity:	150/439 - (34%)	Gaps:	119/439 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 AAPQPLP-WYKRGPHAKFASVETCRPEDVQ------------VAKKL-----VSAGAI-----YE 215
            |.|:..| |:|.      |::....|...:            :|.||     :...||     |:
Yeast     6 AHPETEPKWWKE------ATIYQIYPASFKDSNNDGWGDMKGIASKLEYIKELGTDAIWISPFYD 64

  Fly   216 LPA-ALTYDVKKPE-------VEEKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIA---N 269
            .|. .:.||:...|       ..|....|:........:.|.||..|:.:...:..:::.:   |
Yeast    65 SPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTN 129

  Fly   270 PEKRSAFVW-------VSGGKALPNNWLKVGGNRSAW---EKVGDNYVLSQFEDGYYDLKMNS-- 322
            | ||..|.|       ..|....||||....|. |||   ||..:.| |..|.....||...:
Yeast   130 P-KRDWFFWRPPKGYDAEGKPIPPNNWRSYFGG-SAWTFDEKTQEFY-LRLFCSTQPDLNWENED 191

  Fly   323 ---TIIRNEFGAVLKHLVALGVRGFRLKNTKFFALFDSLEDEQISSSPKDFSL-------GPNEY 377
               .|..:..|..|.|    ||.|||:.....::....|.|..:......:.|       ||..:
Yeast   192 CRKAIYESAVGYWLDH----GVDGFRIDVGSLYSKVAGLPDAPVIDENSKWQLSDPFTMNGPRIH 252

  Fly   378 GFYSHRQTTFLSGLGDVLYDYLSI--VKNASDEA--FFSVAEDVMEPQVYQLS----GDSGAYGI 434
            .|:........:.:.|. .:.:::  :::|:||.  .::.|......:::..|    |.|..:..
Yeast   253 EFHQEMNKFIRNRVKDG-REIMTVGEMRHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFRQ 316

  Fly   435 DLPMYGNFVKVLSKSKPDTSLQKELDNTLAQ-----SGTDSWLQWNLADVYVDTPQDPSALAMFL 494
            :|..|.               .|:....||:     :|||.|     :.:|::....|.::..|.
Yeast   317 NLIPYE---------------LKDWKVALAELFRYVNGTDCW-----STIYLENHDQPRSITRFG 361

  Fly   495 SLLPGVPVVAVDAVAYQNVTEETYRQITSLRKTASYMHGNLNLYQADPL 543
            ...|...|::...::...|:                :.|.|.:||...|
Yeast   362 DDSPKNRVISGKLLSVLLVS----------------LSGTLYVYQGQEL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	88/439 (20%)
IMA3	NP_012096.1	AmyAc_SI_OligoGlu_DGase	16..503	CDD:200472	84/429 (20%)
IMA3	NP_012096.1	Malt_amylase_C	514..585	CDD:406946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770