DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD98hc and IMA1

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_011803.3	Gene:	IMA1 / 853204	SGDID:	S000003519	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	437	Identity:	92/437 - (21%)
Similarity:	151/437 - (34%)	Gaps:	121/437 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 AAPQPLP-WYKRGPHAKFASVETCRPEDVQ---------VAKKL-----VSAGAI-----YELPA 218
            |.|:..| |:|   .|.|..:.....:|..         :|.||     :.|.||     |:.|.
Yeast     6 AHPETEPKWWK---EATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQ 67

  Fly   219 -ALTYDVKKPE-------VEEKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIA---NPEK 272
             .:.||:...|       ..|....|:........:.|.||..|:.:...:..:::.:   || |
Yeast    68 DDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNP-K 131

  Fly   273 RSAFVW-------VSGGKALPNNWLKVGGNRSAW---EKVGDNYVLSQFEDGYYDLKMNS----- 322
            |..|.|       ..|....||||....|. |||   ||..:.| |..|.....||...:
Yeast   132 RDWFFWRPPKGYDAEGKPIPPNNWKSYFGG-SAWTFDEKTQEFY-LRLFCSTQPDLNWENEDCRK 194

  Fly   323 TIIRNEFGAVLKHLVALGVRGFRLKNTKFFALFDSLEDEQI--------SSSPKDFSLGPNEYGF 379
            .|..:..|..|.|    ||.|||:.....::....|.|..:        ||.|...: ||..:.|
Yeast   195 AIYESAVGYWLDH----GVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLN-GPRIHEF 254

  Fly   380 YSHRQTTFLSGLGDVLYDYLSI--VKNASDEA--FFSVAEDVMEPQVYQLS----GDSGAYGIDL 436
            :........:.:.|. .:.:::  :::||||.  .::.|......:::..|    |.|..:..:|
Yeast   255 HQEMNQFIRNRVKDG-REIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNL 318

  Fly   437 PMYGNFVKVLSKSKPDTSLQKELDNTLAQ-----SGTDSWLQWNLADVYVDTPQDPSALAMF--- 493
            ..:.               .|:....||:     :|||.|     :.:|::....|.::..|
Yeast   319 VPFE---------------LKDWKIALAELFRYINGTDCW-----STIYLENHDQPRSITRFGDD 363

  Fly   494 ---------------LSLLPGVPVV----AVDAVAYQNVTEETYRQI 521
                           ||.|.|...|    .:..:.::|...|.|..:
Yeast   364 SPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDV 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	92/437 (21%)
IMA1	NP_011803.3	AmyAc_SI_OligoGlu_DGase	16..503	CDD:200472	88/427 (21%)
IMA1	NP_011803.3	Malt_amylase_C	514..585	CDD:413446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770