DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD98hc and MAL32

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_009858.3	Gene:	MAL32 / 852602	SGDID:	S000000503	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	382	Identity:	85/382 - (22%)
Similarity:	132/382 - (34%)	Gaps:	104/382 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 YELPAA-LTYDVKKPE-------VEEKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIA-- 268
            |:.|.. :.||:...|       ..|....|:........:.|.||..|:.:...:..:::.:
Yeast    62 YDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSK 126

  Fly   269 -NPEKRSAFVW-------VSGGKALPNNWLKVGGNRSAW--EKVGDNYVLSQFEDGYYDLKMNS- 322
             || ||..|.|       ..|....||||....|. |||  ::..:.:.|..|.....||...:
Yeast   127 TNP-KRDWFFWRPPKGYDAEGKPIPPNNWKSFFGG-SAWTFDETTNEFYLRLFASRQVDLNWENE 189

  Fly   323 ----TIIRNEFGAVLKHLVALGVRGFRLKNTKFFALFDSLEDEQISSSPKDFS-------LGP-- 374
                .|..:..|..|.|    ||.|||:.....::....|.|..|........       .||
Yeast   190 DCRRAIFESAVGFWLDH----GVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRI 250

  Fly   375 NEYGFYSHRQTTFLSG----------LGDVLYDYLSIVKNASDEAFFSVAEDVMEPQVYQLS--- 426
            :||....||   |:..          :|:|.:        .||.|.::.|......:|:..:
Yeast   251 HEYHQELHR---FMKNRVKDGREIMTVGEVAH--------GSDNALYTSAARYEVSEVFSFTHVE 304

  Fly   427 -GDSGAYGIDLPMYG-NFVKVLSKSKPDTSLQ-KE--LDNTLAQSGTDSWLQWNLADVYVDTPQD 486
             |.|       |.:. |.|       |.|..| ||  ..|.|..:|||||     |..|::....
Yeast   305 LGTS-------PFFRYNIV-------PFTLKQWKEAIASNFLFINGTDSW-----ATTYIENHDQ 350

  Fly   487 PSALAMFLSLLPGVPVVAVDAVAYQNVTEETYRQITSLRKTASYMHGNLNLYQADPL 543
            ..::..|          |.|:..|:.::.   :.:|.|..:   :.|.|.:||...:
Yeast   351 ARSITRF----------ADDSPKYRKISG---KLLTLLECS---LTGTLYVYQGQEI 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	85/382 (22%)
MAL32	NP_009858.3	AmyAc_SI_OligoGlu_DGase	15..501	CDD:200472	85/382 (22%)
MAL32	NP_009858.3	Malt_amylase_C	511..583	CDD:406946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770