DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CD98hc and SLC3A2

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001012680.1	Gene:	SLC3A2 / 6520	HGNCID:	11026	Length:	631	Species:	Homo sapiens

Alignment Length:	693	Identity:	145/693 - (20%)
Similarity:	237/693 - (34%)	Gaps:	250/693 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DSTINAAAEYPPDSTEVYKTIAEDTFVAASSNPEKVDMVQDEKAAHADGADEQMLGSNGVEDKLA 92
            |.|.:|:.     |..:..|:::||         :||| ::.:....:...:.|..::|....||
Human    88 DPTASASG-----SAGITGTMSQDT---------EVDM-KEVELNELEPEKQPMNAASGAAMSLA 137

  Fly    93 ERRDEVKFIKGDHQNGDAKIDIGTVNGGKPA---FTGMSKEELMKYANDPFWVRLRWIFFVCFWA 154
                      |..:||..||.:........|   |||:|||||:|.|..|.|||.||...:.||.
Human   138 ----------GAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWL 192

  Fly   155 IWVGMLVGAILIIIGAPKCAAPQPLPWYKRGPHAKFASVETCRPEDVQVAKKLVSAGAIYELPAA 219
            .|:|||.||::||:.||:|.......|:..|...:...::..:..         .||.:..|...
Human   193 GWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGH---------GAGNLAGLKGR 248

  Fly   220 LTY--------------------DVKKPEV---------EEKIKHLVALYQGSDTRVILDLTPNY 255
            |.|                    ||.:.::         :|....|:...:....||||||||||
Human   249 LDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNY 313

  Fly   256 AAKNS--QLVQDAIANPEKRSAFVWVSGGKALPNNWLKVGGNRSAWEKVGDNYVLSQFEDGYYDL 318
            ..:||  ....|.:|...|.:...|:..|.                    |.:.:...|    :|
Human   314 RGENSWFSTQVDTVATKVKDALEFWLQAGV--------------------DGFQVRDIE----NL 354

  Fly   319 KMNSTIIRNEFGAVLK-----HLVALGVRGFRLKNTKFFALFDSLEDEQISSSPKDFSLGPNEYG 378
            |..|:.:. |:..:.|     .|:..|.....|:  :..:|.:|.:|..::||
Human   355 KDASSFLA-EWQNITKGFSEDRLLIAGTNSSDLQ--QILSLLESNKDLLLTSS------------ 404

  Fly   379 FYSHRQTTFLSGLGDVLYDYLSIVKNASDEAFFSVAEDVMEPQVYQLSGDSGAYGIDLPMYGNFV 443
                               |||                           |||:.|
Human   405 -------------------YLS---------------------------DSGSTG---------- 413

  Fly   444 KVLSKSKPDTSLQKELDNTLAQSGTDSWLQWNLADVYVDTPQDPSAL----AMFLSLLPGVPV-- 502
                      ...|.|......:..:.|..|:|:...:.|...|:.|    .:.|..|||.||
Human   414 ----------EHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFS 468

  Fly   503 ----VAVDAVAY-------------------------QNVTEE-----------TYRQITSLR-K 526
                :.:||.|.                         .|:|.:           .:|:::..| |
Human   469 YGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSK 533

  Fly   527 TASYMHGNLNLYQADP-LVAFSRIKSGNPGYFVIFNPTELP-----QASNFTIPDNLPDKMTVSY 585
            ..|.:||:.:.:.|.| |.::.|....|..:.|:.|..::.     |||:.....:||.|..:..
Human   534 ERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLL 598

  Fly   586 FSEQYNNNMDNSGKVAHAGR-----VNLKDLKVAPHSSIILTY 623
            .::              .||     :.|:.||:.||..::|.:
Human   599 STQ--------------PGREEGSPLELERLKLEPHEGLLLRF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	118/567 (21%)
SLC3A2	NP_001012680.1	SLC3A2_N	161..225	CDD:292647	31/63 (49%)
		AmyAc_SLC3A2	208..537	CDD:200483	75/442 (17%)
		AmyA	238..597	CDD:223443	86/463 (19%)
		DUF3459	520..625	CDD:288769	26/118 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9191
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S6632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0004629
OrthoInspector	1	1.000	-	-		oto88515
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.730