Protein Alignment CD98hc and SLC3A1

DIOPT Version :9

• Sequence 1: NP_001262354.2
• Gene: CD98hc / 40941
• FlyBaseID: FBgn0037533
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000332.2
• Gene: SLC3A1 / 6519
• HGNCID: 11025
• Length: 685
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 138/623 - (22%)
• Similarity: 226/623 - (36%)
• Gaps: 176/623 - (28%)

  Fly    65 MVQDEKAAHADGADEQMLG---SNGV---EDKLAERRD----------EVKFIKGDHQNGDAKID 113
            |.:|:  :..|..:..|.|   :||.   ||.|.:..|          ..:.|.|. |..|.|
Human     1 MAEDK--SKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGS-QEPDFK-- 60

  Fly   114 IGTVNGGKPAFTGMSKEELMKYANDPFWVRLRWIFFVCFWAIWVGMLVGAILIIIGA-------- 170
                  |...:.||.||.|.:::..   .|.|....:.||     :.|.::|::|.|
Human    61 ------GVQPYAGMPKEVLFQFSGQ---ARYRIPREILFW-----LTVASVLVLIAATIAIIALS 111

  Fly   171 PKCAAPQPLPWYKRGP-----HAKFASVETCRPEDVQ-VAKKLVSAGAIYELPAALT-------- 221
            |||     |.|::.||     ...|.........|:: :..||....|:......:|
Human   112 PKC-----LDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLK 171

  Fly   222 ---YDVKK-PEVE------EKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIANPEK-RSA 275
               |.|:. .||:      |..::|||.......::|:|..||:.:......|.:.....| ...
Human   172 DFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDY 236

  Fly   276 FVW----VSGGKAL-PNNWLKVGGNRSAW--EKVGDNYVLSQFEDGYYDLKMNSTIIRNEFGAVL 333
            ::|    ...||.: |||||.|.|| |:|  ::|.:.....||.....||...:..::.|...:|
Human   237 YIWHDCTHENGKTIPPNNWLSVYGN-SSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEIL 300

  Fly   334 KHLVALGVRGFRLKNTKFFALFDSLEDE-QISSSPKDFSLGPNEYGFYSHRQTTFLSGLGDVLYD 397
            :..:..||.||.|...||......|.|| |::.:....::  .:|....|..||...|:.|::..
Human   301 RFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTV--TQYSELYHDFTTTQVGMHDIVRS 363

  Fly   398 YLSIVKNASDE----AFF---SVAEDVMEPQVYQLSGDSGAYGI------DLPMYGNFVKVLSKS 449
            :...:...|.|    .|.   :.||.:....:|        ||:      |.| :.|::.:|
Human   364 FRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMY--------YGLPFIQEADFP-FNNYLSML--- 416

  Fly   450 KPDT----SLQKELDNTLAQSGTDSWLQW------------NLADVYVDTPQDPSALAMFLSLLP 498
              ||    |:.:.:.:.:.......|..|            .|.:.||      :.:.|.|..||
Human   417 --DTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYV------NVMNMLLFTLP 473

  Fly   499 GVPV------VAVDAVAYQNVTEETYRQITSLRKTASYMHGNLNLYQADPLVAFSRIKSGNPGYF 557
            |.|:      :.:..:...|: .|:| .|.:||..:.....|                |.|.|:
Human   474 GTPITYYGEEIGMGNIVAANL-NESY-DINTLRSKSPMQWDN----------------SSNAGF- 519

  Fly   558 VIFNPTELPQASNFTIPDNLPDKMTVSYFSEQYNNNMD 595
                    .:|||..:|.|          |:.:..|:|
Human   520 --------SEASNTWLPTN----------SDYHTVNVD 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	120/551 (22%)
SLC3A1	NP_000332.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		13/57 (23%)
		AmyAc_SLC3A1	116..569	CDD:200494	104/484 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820