DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CD98hc and Slc3a1

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_058912.1	Gene:	Slc3a1 / 29484	RGDID:	3709	Length:	683	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	130/583 - (22%)
Similarity:	215/583 - (36%)	Gaps:	154/583 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EDKLAERRDEVKF-IKG-------------DHQNGDAKIDIGTVNG-GKPA-----------FTG 126
            |||  ::||.::. :||             ..|:.|:: |....|. ..||           :.|
  Rat     3 EDK--DKRDSIQMSMKGCRTNNGFVQNEDIQEQDPDSR-DTPQSNAVSIPAPEEPQLKVVRPYAG 64

  Fly   127 MSKEELMKYANDPFWVRLRWIFFVCFW--AIWVGMLVGA-ILIIIGAPKCAAPQPLPWYKRGP-- 186
            |.||.|.:::..   .|.|....:.||  .:.|.:|:|| |.|||.:|||     |.|::.||
  Rat    65 MPKEVLFQFSGQ---ARYRVPREILFWLTVVSVFLLIGATIAIIIISPKC-----LDWWQAGPMY 121

  Fly   187 ---HAKFASVETCRPEDVQ-VAKKLVSAGAIYELPAALTYDVKKP------------EVE----- 230
               ...|...:.....|:: :.:||....|:......:|...|.|            |::
  Rat   122 QIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGT 186

  Fly   231 -EKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIANPEK-RSAFVW-----VSGGKALPNN 288
             :..::|||.......::|:|..||:.:......|.:.....| ...::|     .:|....|||
  Rat   187 MKDFENLVAAVHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHANGVTTPPNN 251

  Fly   289 WLKVGGNRSAW--EKVGDNYVLSQFEDGYYDLKMNSTIIRNEFGAVLKHLVALGVRGFRLKNTKF 351
            ||.|.|| |:|  ::........||.....||...:..::.|...::|..::.||.||.....||
  Rat   252 WLSVYGN-SSWQFDEERKQCYFHQFLKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKF 315

  Fly   352 FALFDSLEDE-QISSSPKDFSLGPNEYGFYS---HRQTTFLSGLGDVLYDYLSIVKNASDE---- 408
            ......|.:| |:::|..     |:....||   |..||...|:.|::.|:...:...|.|
  Rat   316 LLEAKDLRNEIQVNTSQI-----PDTVTRYSELYHDFTTTQVGMHDLVRDFRQTMNQFSREPGRY 375

  Fly   409 AFFSV---AEDVMEPQVYQLSGDSGAYGI------DLPMYGNFVKVLSKSKPDTSLQKELDNTLA 464
            .|...   ||......||        ||:      |.| :..::..|......| :.:.:.:.:.
  Rat   376 RFMGTEVSAESTERTMVY--------YGLSFIQEADFP-FNKYLATLDTLSGHT-VYEAITSWME 430

  Fly   465 QSGTDSWLQW------------NLADVYVDTPQDPSALAMFLSLLPGVPV------VAVDAVAYQ 511
            ......|..|            .:...||      :|:.|.|..|||.|:      :.:..::..
  Rat   431 NMPEGKWPNWMIGGPETSRLTSRVGSEYV------NAMNMLLFTLPGTPITYYGEEIGMGDISIT 489

  Fly   512 NVTEETYRQITSLRKTASYMHGNLNLYQADPLVAFSRIK---SGNPGYFVIFNPTELPQASNF 571
            |:.|.                     |..:.|::.|.::   |.|.| |...|.|.||..|::
  Rat   490 NLNER---------------------YDTNALLSKSPMQWDNSSNAG-FTEANHTWLPTNSDY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	120/540 (22%)
Slc3a1	NP_058912.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		11/49 (22%)
Slc3a1	NP_058912.1	AmyAc_SLC3A1	113..566	CDD:200494	96/462 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820