Protein Alignment CD98hc and AMY2B

DIOPT Version :9

• Sequence 1: NP_001262354.2
• Gene: CD98hc / 40941
• FlyBaseID: FBgn0037533
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001373038.1
• Gene: AMY2B / 280
• HGNCID: 478
• Length: 511
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 98/471 - (20%)
• Similarity: 167/471 - (35%)
• Gaps: 137/471 - (29%)

  Fly   230 EEKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIANPEKRSAFVWVSGGKALPNNWLKVGG 294
            |::.:::|........|:.:|...|:.:.|:                  ||.|.:.........|
Human    91 EDEFRNMVTRCNNVGVRIYVDAVINHMSGNA------------------VSAGTSSTCGSYFNPG 137

  Fly   295 NR-------SAWE------KVG----DNY-VLSQFED----GYYDLKMNSTIIRNEFGAVLKHLV 337
            :|       |.|:      |.|    :|| ..:|..|    |..||.:....:|::....:.||:
Human   138 SRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGLLDLALEKDYVRSKIAEYMNHLI 202

  Fly   338 ALGVRGFRLKNTKFF------ALFDSLEDEQISSSP---KDF------SLG-----PNEYGFYSH 382
            .:||.||||..:|..      |:.|.|.:...:..|   |.|      .||     .::| |.:.
Human   203 DIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDY-FGNG 266

  Fly   383 RQTTFLSG--LGDVLYDY----LSIVKN--------ASDEAFFSVAE---------------DVM 418
            |.|.|..|  ||.|:..:    :|.:||        .||.|...|..               ...
Human   267 RVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFW 331

  Fly   419 EPQVYQLSGDSGAYGIDLPMYGNFVKVLSKSKPDTSLQKELDNTLAQSGTDSWLQWNLADVYVDT 483
            :.::|::     |.|..|.....|.:|:|..:.....|...|       .:.|:          .
Human   332 DARLYKM-----AVGFMLAHPYGFTRVMSSYRWPRQFQNGND-------VNDWV----------G 374

  Fly   484 PQDPSALAMFLSLLPGVPVVAVDAVAYQN-VTEETYRQITSLRKTASYMHGN--LNLY-QADPLV 544
            |.:.:.:...:::.|       |.....: |.|..:|||.::....:.:.|.  .|.| .....|
Human   375 PPNNNGVIKEVTINP-------DTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQV 432

  Fly   545 AFSRIKSGNPGYFVIFNPTELPQASNFTIPDNLPDKMTVSYFS-EQYNNN-------MDNSGKVA 601
            ||.|   ||.| |::||..:  ...:.|:...||........| ::.|.|       :.:.||..
Human   433 AFGR---GNRG-FIVFNNDD--WTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAH 491

  Fly   602 HAGRVNLKDLKVAPHS 617
            .:...:.:|..:|.|:
Human   492 FSISNSAEDPFIAIHA 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	92/438 (21%)
AMY2B	NP_001373038.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	74/372 (20%)
		PLN02447	<85..>155	CDD:215246	13/81 (16%)
		Aamy_C	422..510	CDD:214749	23/92 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900