DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CD98hc and Mal-A6

DIOPT Version :9

Sequence 1:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_724679.2	Gene:	Mal-A6 / 246565	FlyBaseID:	FBgn0050360	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	115/525 - (21%)
Similarity:	193/525 - (36%)	Gaps:	127/525 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 IYELPAA-LTYDVK-----KPE--VEEKIKHLVALYQGSDTRVILDLTPNYAAKNSQLVQDAIAN 269
            ||..|.| ..||:.     :||  .......|:|..:..:.::|||..||:::..:...|.::..
  Fly    91 IYSSPMADFGYDISDFFDIQPEYGTLADFDELIAEAKKRNIKIILDFVPNHSSDENVWFQKSVKR 155

  Fly   270 PEK--RSAFVW-------VSGGKALPNNWLKV-GGNRSAWEKVGDNYVLSQFEDGYYDLKMNSTI 324
             ||  ...::|       .:|.:..|:|||:. .|:...|......|.|.||.....||...:..
  Fly   156 -EKGYEDYYMWHDGYVNATTGKREPPSNWLQAFRGSAWEWNDERQQYYLHQFAVKQPDLNYRNPA 219

  Fly   325 IRNEFGAVLKHLVALGVRGFRLKNTK--FFALFDS---LEDEQISSSPKDFSLGPNEYGFYSHRQ 384
            :..:...||.:.:..||.|||:....  |..|.|:   ..||.:|....|    |::..:..|..
  Fly   220 VVAQMKRVLTYWLDRGVAGFRMDAVPWCFEVLPDADGRYPDEPLSGYTDD----PDDSSYLKHIY 280

  Fly   385 TTFLSGLGDVLYDYLSIVK-----NASDEAFFSVAEDVMEPQVYQLSGDSGAYGIDLP------M 438
            |..|....::::.:.:::.     :..|.....|........|.|..|:....|..:|      :
  Fly   281 TQDLRETVEMVFQWRTLLDDYQRIHGGDTRVIMVETYSGLDYVMQFYGNRTTKGAQMPFNFQFII 345

  Fly   439 YGN------------FVKVLS-----------------------------KSKPD--TSLQKELD 460
            .||            |||::|                             :::.|  ..||..|.
  Fly   346 GGNGDKNNTQLNATGFVKIISSWLSQMPAGQTANWVMGNHDQRRVGSRYGENRIDLMNMLQMFLP 410

  Fly   461 N-TLAQSG-----TDSWLQW----------NLADVYVDTPQDPS---------ALAMF----LSL 496
            . ::...|     ||..:.|          :.:|:|....:||:         |.|.|    .:.
  Fly   411 GVSITYQGEELGMTDLDISWEDSRDPAACNSNSDIYEQFTRDPARTPFQWSDEANAGFSTNATTW 475

  Fly   497 LPGVP-VVAVDAVAYQNVTEET----YRQITSLRKTASYMHGNLNLYQ-ADPLVAFSRIKSGNPG 555
            ||..| .|.|:|.| :|.|..:    |:|:..|||:.:...|...... .|.:||..|..||.|.
  Fly   476 LPINPNYVTVNAKA-ENSTSPSHLSLYKQLVDLRKSKTLQFGATRYANVGDNVVAIRRYLSGEPS 539

  Fly   556 YFVIFNPTELPQASNFTIPDNLPDKMTVSYFSEQYNNNMDNSGKVAHAG-RVNLKDLKVAPHSSI 619
            |.::.|..:...:.        .|..:..|.:..|...:.|....|..| .|.|.:|.:.|::::
  Fly   540 YVLVANVLDTSVSG--------IDVASAIYATGSYKIKLLNPQAKATVGDSVTLSNLTLEPYAAL 596

  Fly   620 ILTYV 624
            ||..|
  Fly   597 ILESV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	105/491 (21%)
Mal-A6	NP_724679.2	AmyAc_maltase	40..516	CDD:200467	92/430 (21%)
Mal-A6	NP_724679.2	trehalose_treC	43..599	CDD:274115	113/521 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S6632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.770