DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dsx and DMRTA1

DIOPT Version :9

Sequence 1:	NP_001262353.1	Gene:	dsx / 40940	FlyBaseID:	FBgn0000504	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_071443.2	Gene:	DMRTA1 / 63951	HGNCID:	13826	Length:	504	Species:	Homo sapiens

Alignment Length:	319	Identity:	87/319 - (27%)
Similarity:	113/319 - (35%)	Gaps:	82/319 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASSSSGSSISPRTP----------------PNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLT 76
            |:::|||...|..|                |.||||||||:...||||||:|::|.|.|.||.|.
Human    65 AAATSGSGGCPPAPGLESGVGAVGCGYPRTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLI 129

  Fly    77 ADRQRVMALQTALRRAQAQDEQRALHMHEV-------PPANPAATTLLSHHHHVAAPAHVHAHHV 134
            |:||||||.|.||||.|||:|..|..:..:       ||
Human   130 AERQRVMAAQVALRRQQAQEESEARGLQRLLCSGLSWPP-------------------------- 168

  Fly   135 HAHHAHGGHHSHHGHVLHHQQAA---AAAAAAPSAPASHLGGSSTAASSIHGHAHAHHVHMAAAA 196
                  ||..|..|....:.|:.   ||.||..........||:|.|..:....:...
Human   169 ------GGRASGGGGRAENPQSTGGPAAGAALGLGALRQASGSATPAFEVFQQDYPEE------- 220

  Fly   197 AASVAQHQHQSHPHSHHHHHQNHHQHPHQQPATQTALRSPPHSDHGGSVGPATSSSGGGAPSSSN 261
                .|.|.:|...|..:..:......||       |.....|...|.:|  ..|.|......||
Human   221 ----KQEQKESKCESCQNGQEELISKSHQ-------LYLGSSSRSNGVIG--KQSIGSSISEYSN 272

  Fly   262 AAAATSS---NGSSGGGGGGGGGSSGGGAGGGRSSGTSVITSADHHMTTVPT-PAQSLE 316
            ...:..|   ...|||.......||.....|..|.....:|:....:.||.: |...|:
Human   273 KPDSILSPHPGEQSGGEESPRSLSSSDLESGNESEWVKDLTATKASLPTVSSRPRDPLD 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsx	NP_001262353.1	DM	41..86	CDD:279137	30/60 (50%)
dsx	NP_001262353.1	DSX_dimer	353..404	CDD:285978
DMRTA1	NP_071443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		DM	93..139	CDD:279137	29/45 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..192		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..307		9/40 (23%)
		CUE_DMA_DMRTA1	325..364	CDD:270600	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900