DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dsx and DMRT1

DIOPT Version :9

Sequence 1:	NP_001262353.1	Gene:	dsx / 40940	FlyBaseID:	FBgn0000504	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_011516072.1	Gene:	DMRT1 / 1761	HGNCID:	2934	Length:	390	Species:	Homo sapiens

Alignment Length:	394	Identity:	80/394 - (20%)
Similarity:	117/394 - (29%)	Gaps:	159/394 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 LRSPPH----------------SDHGGSVG---PAT---------------------SSSGGGAP 257
            ::||.|                :|.||:.|   |||                     :|.|.|.|
Human     1 MKSPQHGRCHAGPGLWRDAAVLADSGGAWGPGLPATLHRRSGSAGDASDPARRAELRASLGSGFP 65

  Fly   258 SSSNAAAATSSNGS--------------SGGGGGGGGG-----------SSGGGAGGGRSSGTSV 297
            :.|:.....|..||              :|..|....|           ..||......|||:|:
Human    66 TISHPVFRRSCGGSLCSRVPEIPDPALRAGNSGVRPSGLPRDPRARVPTELGGFIALEESSGSSL 130

  Fly   298 ITS--------------ADHHMTTVPTPAQSL-----EGS-------CD-SSSPSPSS--TSGAA 333
            ..|              ...|...:|:.|:.|     .||       |. :|.|.|:|  |:.|:
Human   131 PPSEVALRRQQAQEEELGISHPIPLPSAAELLVKRENNGSNPCLMTECSGTSQPPPASVPTTAAS 195

  Fly   334 -----ILPISVSVNRKNGANVPLGQDVFLDYCQKLLEKFRYPWELMPL--------MYVILKDAD 385
                 |..|....:|.:..|.|   |:..|  ......|..| .|.|.        .|.:...||
Human   196 EGRMVIQDIPAVTSRGHVENTP---DLVSD--STYYSSFYQP-SLFPYYNNLYNCPQYSMALAAD 254

  Fly   386 ANIEEASRRI--------------------------EEARVEINRTVAQIY--YNYYTPMA-LVN 421
            :...|....:                          :...:|....::..|  ::||.|.: |..
Human   255 SASGEVGNPLGGSPVKNSLRGLPGPYVPGQTGNQWQQMKNMENRHAMSSQYRMHSYYPPPSYLGQ 319

  Fly   422 GAPMYLTY---PSIEQGRYGAHFTHLPLTQICPPTPEPLAL----SRSPSSPSGPSAVHNQKP-S 478
            ..|.:.|:   ||..:.|         .:...||:.:...|    |.||.|.....||...:| |
Human   320 SVPQFFTFEDAPSYPEAR---------ASVFSPPSSQDSGLVSLSSSSPISNKSTKAVLECEPAS 375

  Fly   479 RPGS 482
            .|.|
Human   376 EPSS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsx	NP_001262353.1	DM	41..86	CDD:279137
dsx	NP_001262353.1	DSX_dimer	353..404	CDD:285978	11/84 (13%)
DMRT1	XP_011516072.1	Dmrt1	146..218	CDD:289167	18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6174
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12322
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4813
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950